A multi‐site Canadian perspective: examining the functional outcome from first‐episode psychosis

Menezes, Natasja; Malla, Ashok; Norman, Ross; Archie, Suzanne; Roy, Paul; Zipursky, Robert B.

doi:10.1111/j.1600-0447.2009.01346.x

Cited by 57 publications

(48 citation statements)

References 54 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In AOS, positive symptoms appeared to have an impact on functional outcome in some studies of chronic schizophrenia [18] and first-episode psychosis [71]. In EOS, some previous studies have found a significant relationship between positive symptoms and functional outcome [25] but others have not [27].…”

Section: Discussionmentioning

confidence: 97%

Processing speed and executive functions predict real-world everyday living skills in adolescents with early-onset schizophrenia

Puig

Penadés

Baeza

et al. 2012

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

Cognition and clinical variables are known to be among the most predictive factors of real-world social functioning and daily living skills in adult-onset schizophrenia. Fewer studies have focused on their impact in adolescents with early-onset schizophrenia (EOS). The aim of this study is to examine the relationships and the predictive value of cognition and clinical variables on real-world daily living skills in a sample of adolescents with EOS. Cognitive, clinical and real-world everyday living skills measures were administered to 45 clinically and pharmacologically stabilized adolescent outpatients with EOS and 45 healthy control subjects matched by age and sex. Multi-variant analyses to compare cognitive and real-world functioning profiles between patients and controls and regression analysis to identify predictors of real-world functioning scores in patients were used. Adolescents with EOS showed a generalized cognitive and real-world daily living skills dysfunction. Several cognitive and clinical variables significantly correlated with real-world daily living skills functioning but only the processing speed and executive functions emerged as independent predictors of everyday living skills scores, explaining 25.1% of the variance. Slowness in processing information and executive dysfunction showed a significant impact on real-world daily living skills in EOS, independently from clinical symptoms and other cognitive variables. Nevertheless, much of the variance in the daily living skills measure remained unaccounted for, suggesting that other factors were involved as well in this young population.

show abstract

Section: Discussionmentioning

confidence: 97%

Processing speed and executive functions predict real-world everyday living skills in adolescents with early-onset schizophrenia

Puig

Penadés

Baeza

et al. 2012

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

show abstract

“…[19] Clinical outcome was measured by 1) Clinical Global Impression Scale (CGIS),[2021] 2)Psychopathology (positive symptoms, negative symptoms and disorganization) using Positive and Negative Syndrome Scale [PANSS),[2223] 3) Depressive symptoms using Hamilton Depression Rating Scale (HDRS)[24] 4) Factors of Compliance, 5) Extrapyramidal symptoms (EPS), using Abnormal Involuntary Movement Scale (AIMS)[25] 6) Aggression, 7) Hospitalization, and 8] Suicidality. Social outcome was measured using 1)Quality of life (QOL),[26] 2) Global Functioning (GAF),[2728] 3)Independent living, 4) Family burden, and 5) Social burden by measured operationalized criteria. Raters in this study were not blinded.…”

Section: Methodsmentioning

confidence: 99%

Effects of duration of untreated psychosis on long-term outcome of people hospitalized with first episode schizophrenia

Shrivastava

Shah

Johnston

et al. 2010

Indian J Psychiatry

View full text Add to dashboard Cite

Duration of untreated psychosis (DUP) has emerged as a reliable predictor of outcome but continues to remain under scientific scrutiny. The present study examines the effect of differential periods of DUP on long-term outcome of first episode schizophrenia at Mumbai, India. This research was a prospective, 10-year follow-up naturalistic study. Hospitalized patients of first episode schizophrenia were selected and followed up. Results showed that the mean DUP was higher for a group which showed clinical recovery on Clinical Global Impression Scale [14.0 months (SD=8.0) in recovered and 10.8 months (SD=5.7) in non-recovered group (P=0.091)]. DUP was not found to be significantly associated with any of the end point parameters of good clinical or social outcome. Thus, this study found that DUP alone does not determine outcome status confirming the role of psychopathological heterogeneity.

show abstract

“…9 This is comparable to estimates of rates of remission of 70%–74% for patients with a FEP. 18,20,21 These high rates of remission may in part reflect the effects of the assertive treatment received in research-intensive services and specialized FEP services, as well as the sampling approaches used. However, the evidence to date suggests that those patients who achieve remission after their first episode are, on average, able to maintain similar rates of remission over the longer term as well; ie, the proportion relapsing is matched by others remitting.…”

Section: Outcome Of Schizophreniamentioning

confidence: 99%

The Myth of Schizophrenia as a Progressive Brain Disease

Zipursky

Reilly

Murray

2012

Schizophrenia Bulletin

279

192

View full text Add to dashboard Cite

Schizophrenia has historically been considered to be a deteriorating disease, a view reinforced by recent MRI findings of progressive brain tissue loss over the early years of illness. On the other hand, the notion that recovery from schizophrenia is possible is increasingly embraced by consumer and family groups. This review critically examines the evidence from longitudinal studies of (1) clinical outcomes, (2) MRI brain volumes, and (3) cognitive functioning. First, the evidence shows that although approximately 25% of people with schizophrenia have a poor long-term outcome, few of these show the incremental loss of function that is characteristic of neurodegenerative illnesses. Second, MRI studies demonstrate subtle developmental abnormalities at first onset of psychosis and then further decreases in brain tissue volumes; however, these latter decreases are explicable by the effects of antipsychotic medication, substance abuse, and other secondary factors. Third, while patients do show cognitive deficits compared with controls, cognitive functioning does not appear to deteriorate over time. The majority of people with schizophrenia have the potential to achieve long-term remission and functional recovery. The fact that some experience deterioration in functioning over time may reflect poor access, or adherence, to treatment, the effects of concurrent conditions, and social and financial impoverishment. Mental health professionals need to join with patients and their families in understanding that schizophrenia is not a malignant disease that inevitably deteriorates over time but rather one from which most people can achieve a substantial degree of recovery.

show abstract

A multi‐site Canadian perspective: examining the functional outcome from first‐episode psychosis

Abstract: After 1 year of treatment, FEP patients show high rates of symptomatic remission and relatively lower rates of functional recovery. Symptoms and substance abuse contribute to variance in outcome.

Cited by 57 publications

References 54 publications

Processing speed and executive functions predict real-world everyday living skills in adolescents with early-onset schizophrenia

Processing speed and executive functions predict real-world everyday living skills in adolescents with early-onset schizophrenia

Effects of duration of untreated psychosis on long-term outcome of people hospitalized with first episode schizophrenia

The Myth of Schizophrenia as a Progressive Brain Disease

Contact Info

Product

Resources

About