Clinical practice of Chinese medicine navel therapy for chronic diarrhea: A literature review

Abstract

Chronic diarrhea is one of the most common complaints in clinical practice for both adults and children. The purpose of this study was to assess the commonly used Chinese herbal medicine navel therapy for the treatment of chronic diarrhea (traditional Chinese medicine syndrome of spleen deficiency). The literature search was up to June 2018. Four types of studies (clinical trials, case series, case reports, and experts' experience) researched on Chinese medicine navel therapy used alone or combined with other therapies for the treatment of chronic diarrhea all included. Information on prescriptions, effectiveness, and safety of intervention was collected. Traditional Chinese Medicine Inheritance Support System V2.5 was used to do data analysis. We included 416 studies. All these studies carried out in 194 cities of China. We obtained the most commonly used single herbs, herbal medicine combination, and Chinese patent medicine for both adults and children. The top 3 single herbs were Caryophylli Flos (Dingxiang), Cinnamomi Cortex (Rougui), and Euodiae Fructus (Wuzhuyu). The most frequently used Chinese patent medicines were Ding Gui Infantile Navel Paste and Huoxiang Zhengqi Liquid. The effectiveness assessment was based on clinical trials, but we did not perform a meta‐analysis because of different study design and unsatisfactory methodological quality. No serious adverse reaction happened in original studies. The application of Chinese medicine navel therapy could be one of the ideal treatments for chronic diarrhea in the future, especially for children. However, high‐quality studies are very needed to provide clear evidence.

Ameliorative effect of Aconite aqueous extract on diarrhea is associated with modulation of the gut microbiota and bile acid metabolism

“…The gut microbiota is an important microbial community in the body and plays a central role in the maintenance of health ( Zhang C. et al, 2022 ). Growing evidence has proven that disruption of the gut microbiota is characteristic of diarrhea ( Chen et al, 2019 ; Breitrück et al, 2021 ; Wu et al, 2021 ; Zhen et al, 2021 ; Chen et al, 2022 ; Lu et al, 2022 ). In our study, 16S rRNA high-throughput sequencing was used to explore whether the structure of the gut microbiota in mice with diarrhea would be altered by administration of AA.…”

Chronic Diarrhea in Children: Experience at A Tertiary Hospital of Bangladesh

“…1 Over 6 billion children suffer from diarrhea worldwide, and around 1.7 billion of them are from Southeast Asia. 1,6 In Bangladesh, Islam et al 12 in 2018, conducted study in DMCH and ICDDR,B they targeted the under 5 year children, as this group was more vulnerable to diarrhea and found 6.4% were Persistent diarrhea. Chronic diarrhea has a broad etiological pattern and includes a number of heterogeneous conditions with a differentcourse.…”

“…2,3 Persistent diarrhea is an episode of diarrhea, which starts acutely, usually of infectious etiology and lasts for 14 days or more. [4][5][6] Chronic Diarrhea is one, which has insidious onset that persists for 14 days or more and usually of non-infectious origin. 7 Diarrheal illnesses are estimated to be responsible for approximately 2 to 4 million-childhood death worldwide each year.…”

Protective effects of Liupao tea against high-fat diet/cold exposure-induced irritable bowel syndrome in rats

“…In clinical practice, the Huoxiang Zhengqi liquid is one of the Chinese patent medicines that are most frequently used as oral medication for chronic diarrhea. It consists of multiple herbs that originated from Song Dynasty in ancient China [ 15 ]. On the other hand, Liupao tea, a type of dark tea, is reported to be capable of treating gastrointestinal tract diseases.…”