Protective effects of Liupao tea against high-fat diet/cold exposure-induced irritable bowel syndrome in rats

Zhou, Dan-Shui; Liu, Xiaotong; Lan, Lunli; Yu, Wenxin; Qiu, Ruijin; Wu, Jianhua; Teng, Cuiqin; Huang, Liyun; Yu, Changjun; Zeng, Yu

doi:10.1016/j.heliyon.2023.e16613

Cited by 4 publications

(4 citation statements)

References 63 publications

(72 reference statements)

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“…In the present study, we have exposed the animals to IC for 3 weeks. Although many studies have used this time frame or even shorter [ 73 , 74 ], in other studies, the time of exposure is longer [ 45 , 46 , 75 , 76 ]. Thus, there is no homogeneity in the exposure time in the in vivo preclinical studies of the effects of beverages.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Effects of Instant Cascara Beverage on the Brain-Gut Axis of Healthy Male and Female Rats

Gallego-Barceló,

Bagues,

Benítez-Álvarez

et al. 2023

Nutrients

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Instant cascara (IC) is a sustainable beverage obtained from dried coffee cherry pulp, rich in nutrients and bioactive compounds. The present research aimed to determine the effects of IC on general health and brain-gut axis parameters of healthy female and male rats. Wistar rats were exposed to IC (10 mg/mL) in their drinking water for 3 weeks. Body weight and solid and liquid intakes were monitored as indicators of food safety. Gastrointestinal transit was radiographically evaluated one day (acute) and 3 weeks (chronic) after the start of IC exposure. Locomotor activity, anxiety, and anhedonia of the animals after 3 weeks of treatment was also studied. Overall, compared to water-exposed animals, IC significantly increased food intake in males (p < 0.0001) and liquid intake in females (p < 0.05) without changes in body weight in either case. IC did not significantly modify gastrointestinal motility parameters after its acute or repeated intake and did not cause any significant behavioral alterations in males or females (p > 0.05). In conclusion, repeated intake of IC at the studied concentration did not negatively affect brain-gut axis functions of healthy male and female rats. Anxiety behavior, diarrhea, constipation, abnormal weight modifications, or other typical effects of toxicity were not observed in animals treated with the new powdered beverage, suggesting its food safety under the studied conditions.

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Section: Discussionmentioning

confidence: 99%

Evaluation of the Effects of Instant Cascara Beverage on the Brain-Gut Axis of Healthy Male and Female Rats

Gallego-Barceló,

Bagues,

Benítez-Álvarez

et al. 2023

Nutrients

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“…The catechins act in a dual modality, stimulating healthy gut microbes and inhibiting the proliferation of Campylobacter jejuni, Bacillus cereus, Escherichia coli, Clostridium perfringens, Legionella pneumophila, and Helicobacter pylori through a disruption of the cell membrane. Furthermore, green-tea polyphenols are able to create an overproliferation of Faecalibacterium, Bifidobacterium, Eubacterium, and Roseburia that lead to an increase in SCFAs with proven effects against colorectal cancer because they suppress lipopolysaccharide synthesis and, consequently, potentiate immune system function and exert an anti-inflammatory action [76][77][78][79][80][81][82]. Citrus fruits, like Citrus reticulate, or mandarin oranges; Citrus sinesis, or sweet oranges; Citrus depressa, or flat lemons; Citrus aurantium, or bitter oranges; and, especially, Citrus tangerine, or tangerines, contain nobiletin, a flavone with a chemical structure of three aromatic rings, each one linked to specific molecular groups.…”

Section: Colon Cancermentioning

confidence: 99%

“…Experiments in a mouse model about an estrogen-receptor (ER) negative mammary tumor showed that polyphenols alone did not induce a significative change in the gut-microbiota composition of healthy mice, even if they reduced significantly the rate of Firmicutes communities; in contrast, after cancer onset, these natural compounds effectively modified gut microbes, leading to a reduction of Proteobacteria and an increase in Bacterioides, compared to the control group. Furthermore, these changes are more evident after a combined administration of both broccoli sprouts and green-tea polyphenols [76][77][78][79][80][81]. Other plants and vegetables have shown antioxidant and anticancer properties.…”

Section: Breast Cancermentioning

confidence: 99%

The Interplay between Medical Plants and Gut Microbiota in Cancer

et al. 2023

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The gut microbiota is a dynamic community of bacteria distributed in the gastroenteric tract and changes in response to diseases, diet, use of antibiotics and probiotics, hygiene status, and other environmental factors. Dysbiosis, a disruption of the normal crosstalk between the host and the microbes, is associated with obesity, diabetes, cancer, and cardiovascular diseases, is linked to a reduction of anti-inflammatory bacteria like Lactobacillus and Roseburia, and to an increase in the growth of proinflammatory species like Ruminococcus gnavus and Bacteroidetes. Some plants possess anticancer properties and various studies have reported that some of these are also able to modulate the gut microbiota. The aim of this work is to evaluate the crucial relationship between medical plants and gut microbiota and the consequences on the onset and progression of cancer. In vivo studies about hematological malignancies showed that beta-glucans tie to endogenous antibeta glucan antibodies and to iC3b, an opsonic fragment of the central complement protein C3, leading to phagocytosis of antibody-targeted neoplastic cells and potentiation of the cytotoxic activity of the innate immune system if administered together with monoclonal antibodies. In conclusion, this review suggests the potential use of medical plants to improve gut dysbiosis and assist in the treatment of cancer.

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“…LBT dramatically relieves IBS through inhibiting expressions of pro-inflammatory cytokines, restoring gastrointestinal functions, and altering microbial patterns. Additionally, LBT also plays a vital role in maintaining the balance of water and fluid metabolisms, with the modulation of aquaporin expression in the gastrointestinal tract and kidneys (Zhou, Liu et al, 2023). LBT extract attenuates the ampicillin sodium-induced pathological damage in the ileum, through the stimulation of gastrointestinal transit, reversion of intestinal microbiota dysbiosis, and maintaining of immune homeostasis (Gong, Ouyang et al, 2020).…”

Section: Antioxidant Effects and Protection Against Organic Damagementioning

confidence: 99%

A systemic review on Liubao tea: A time‐honored dark tea with distinctive raw materials, process techniques, chemical profiles, and biological activities

Feng,

Chen,

Song

et al. 2023

Comp Rev Food Sci Food Safe

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Liubao tea (LBT) is a unique microbial‐fermented tea that boasts a long consumption history spanning 1500 years. Through a specific post‐fermentation process, LBT crafted from local tea cultivars in Liubao town Guangxi acquires four distinct traits, namely, vibrant redness, thickness, aging aroma, and purity. The intricate transformations that occur during post‐fermentation involve oxidation, degradation, methylation, glycosylation, and so forth, laying the substance foundation for the distinctive sensory traits. Additionally, LBT contains multitudinous bioactive compounds, such as ellagic acid, catechins, polysaccharides, and theabrownins, which contributes to the diverse modulation abilities on oxidative stress, metabolic syndromes, organic damage, and microbiota flora. However, research on LBT is currently scattered, and there is an urgent need for a systematical recapitulation of the manufacturing process, the dominant microorganisms during fermentation, the dynamic chemical alterations, the sensory traits, and the underlying health benefits. In this review, current research progresses on the peculiar tea varieties, the traditional and modern process technologies, the substance basis of sensory traits, and the latent bioactivities of LBT were comprehensively summarized. Furthermore, the present challenges and deficiencies that hinder the development of LBT, and the possible orientations and future perspectives were thoroughly discussed. By far, the productivity and quality of LBT remain restricted due to the reliance on labor and experience, as well as the incomplete understanding of the intricate interactions and underlying mechanisms involved in processing, organoleptic quality, and bioactivities. Consequently, further research is urgently warranted to address these gaps.

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Protective effects of Liupao tea against high-fat diet/cold exposure-induced irritable bowel syndrome in rats

Cited by 4 publications

References 63 publications

Evaluation of the Effects of Instant Cascara Beverage on the Brain-Gut Axis of Healthy Male and Female Rats

Evaluation of the Effects of Instant Cascara Beverage on the Brain-Gut Axis of Healthy Male and Female Rats

The Interplay between Medical Plants and Gut Microbiota in Cancer

A systemic review on Liubao tea: A time‐honored dark tea with distinctive raw materials, process techniques, chemical profiles, and biological activities

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