Clinical Practice Guideline

Background:Ragweed allergy represents a challenge for allergists due to its increase in some geographic areas, mainly northern Italy.Objectives:To compare two allergy centers in northern Italy by analyzing both the pollen count and the patient characteristics (sensitization and allergy prevalence) over a 10-year period.Methods:Pollen counts for 10 years (2004–2013) were evaluated and compared in the two centers. Characteristics of patients who were sensitized and allergic to ragweed were analyzed.Results:There was a significantly higher pollen count in Busto Arsizio than in Novi Ligure (p < 0.001). The patients who were seen in the Busto Arsizio center showed more frequent sensitization (p < 0.01) and allergy (p < 0.05) to ragweed than patients who were seen in the Novi Ligure center. The pollen count was significantly (p < 0.01) associated with sensitization and allergy difference. Allergic asthma was more frequent (p < 0.05) in Busto Arsizio.Conclusions:The pattern of sensitization and allergy prevalence seemed to be associated with ragweed pollen pressure, such as quantity. The knowledge of the pollen count is relevant in clinical practice, mainly for the management of patients with allergy.

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“…Allergic rhinitis (AR) and allergic asthma (AA) were diagnosed according to international guidelines. 12,13 …”

Section: Methodsmentioning

confidence: 99%

Ragweed Allergy: Pollen Count and Sensitization and Allergy Prevalence in Two Italian Allergy Centers

Ariano

Berra

Chiodini

et al. 2015

Allergy�Rhinol (Providence)

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“…Allergic rhinitis (AR) is a persistent, inflammatory disease characterized by anterior or posterior rhinorrhoea, nasal itching, sneezing, and nasal congestion which reduces people's quality of life and work efficiency (Seidman et al, 2015;Brożek et al, 2017). Currently, antihistamines are the main clinical drugs for AR.…”

Section: Introductionmentioning

confidence: 99%

Astragalus Polysaccharides/Chitosan Microspheres for Nasal Delivery: Preparation, Optimization, Characterization, and Pharmacodynamics

et al. 2020

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Chitosan (CTS) constitutes a promising area in treatment of nose-related diseases as a nasal drug delivery carrier. Astragalus polysaccharide (APS) significantly attenuates eosinophils and neutrophil-dominant airway inflammation, and it has a potential pharmaceutical application in the treatment of severe asthma. The purpose of this work was to prepare APS/CTS microspheres intended for nasal drug delivery by the spray-drying method. The characteristics of APS/CTS microspheres were evaluated by a scanning electron microscope, Fourier transform infrared spectroscopy, differential scanning calorimetry, and in vitro drug release. The effect of APS/CTS microspheres on rats with allergic rhinitis (AR) was investigated by eosinophil and neutrophil counts in nasal lavage fluid. Results of SEM showed that microspheres were spherical and wrinkled. In vitro release showed that 67.48-93.76% APS was released from APS/CTS microspheres at pH 6.8 within 24 h. The effects showed that APS/CTS microspheres alleviated allergic symptoms and reduced eosinophils infiltration and the expression of interleukin-4 in the nasal mucosa tissue of rats that had no liver and kidney toxicity by hematoxylin-eosin staining observation. In conclusion, these results indicated that APS/CTS microspheres had excellent characteristics for the treatment of AR.

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“…6 La rinitis alérgica tiene un gran impacto en la calidad de vida de los pacientes afectados, alcanzando peores indicadores que la diabetes mellitus, artritis reumatoide, migraña y asma. 1,2,4,7 No solo por sus síntomas locales, sino secundarios a alteraciones del sueño, deterioro de la autoestima social y fatiga general. 3 El control de la enfermedad es difícil, costoso y con múltiples alternativas.…”

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“…Afecta a 10-30% de los adultos y más del 40% de los niños, siendo la sintomatología más prominente entre los 10-40 años. 1,2 La RA afecta muchos aspectos de la función diurna. Los pacientes con RA se quejan de dificultad para concentrarse, problemas prácticos en el cuidado de su secreción nasal, estornudos, cansancio y la interferencia con las relaciones interpersonales.…”

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2017

Rev Med UAS

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Valoración de la respuesta terapéutica en pacientes con rinitis alérgica mediante SNOT-22 y ESPRINT-15. Burgos Resumen Introducción: La rinitis alérgica representa una patología común en pacientes pediátricos y adultos, afectando significativamente la calidad de vida del paciente, en ocasiones, de difícil control. Objetivo: Determinar el impacto del tratamiento de inmunoterapia comparado con tratamiento medicamentoso convencional, valorado mediante los cuestionarios SNOT22 y ESPRINT15. Metodología: Estudio experimental, aleatorizado, prospectivo y comparativo. Donde se incluyeron pacientes con diagnóstico de rinitis alérgica severa. Aleatorización en 2 grupos de tratamiento: Inmunoterapia (GrupoIT) y tratamiento convencional (GrupoTC). Seguimiento a 12 meses. Se evaluó la persistencia de síntomas en cuestionarios SNOT22 y ESPRINT15. Resultados: Se incluyeron 45 pacientes. 23 pacientes en GrupoIT y 22 pacientes en GrupoTC. Un SNOT22 Inicial en GrupoIT de 53.3 y final de 24.6 (p <0.005). En el GrupoTC 57.5 inicial y 42.8 final (p=.003). Con mejoría en ambos grupos, siendo mayor en el GrupoIT, con una diferencia de 18.2 puntos. En el cuestionario de ESPRINT15 GrupoIT 45.6 inicial y 18.5 final (p=.005) y en GrupoTC 49.7 inicial y 35.5 final (p=.001). No se reportaron efectos adversos en el grupo de Inmunoterapia. 5/23 pacientes, presentaron recaída de síntomas alérgicos, referidos en menor intensidad. Conclusiones: La Inmunoterapia es más efectiva y segura que los antihistamínicos orales y corticoesteroides tópicos nasales en el tratamiento de la rinitis alérgica severa a largo plazo. Se recomienda aplicar los cuestionarios de calidad de vida SNOT22 Y ESPRINT15 a todo paciente con sospecha de rinosinusitis crónica y rinitis alérgica sin importar su clasificación ARIA.Palabras clave: Rinitis alérgica, Inmunoterapia, SNOT22, ESPRINT15 Abstract Introduction: Allergic rhinitis is a common disease in pediatric and adult patients, affecting the quality of life of patients, sometimes with persistent symptoms despite treatment. Objective: To determine the impact of conventional medical treatment vs immunotherapy, assessed with SNOT-22 and ESPRINT-15 questionnaires. Methodology: Experimental, randomized, prospective and comparative study. We included patients with diagnosis of severe allergic rhinitis. They were randomized into two treatment groups: Immunotherapy (GrupoIT) and conventional treatment (GrupoTC). Follow up to 12 months. The variable of primary interest was the persistence of symptoms in questionnaires for quality of life, ESPRINT15 and SNOT22 were applied. Results: 45 patients were included. 23 patients at GrupoIT and 22 patients at GrupoTC. Initial SNOT22 in GrupoIT of 53.3 and final 24.6 (p <0.005). In GrupoTC, Initial 57.5 and 42.8 final (p = .003). We observed improvement in both groups, higher at GrupoIT, with a difference of 18.2 points. In the questionnaire ESPRINT15 initial 45.6 and final 18.5 GrupoIT (p = .005) and initial 49.7 GrupoTC and final 35.5 (p = .001). No adverse effects were reported in the ...

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Clinical Practice Guideline

Cited by 161 publications

References 12 publications

Ragweed Allergy: Pollen Count and Sensitization and Allergy Prevalence in Two Italian Allergy Centers

Ragweed Allergy: Pollen Count and Sensitization and Allergy Prevalence in Two Italian Allergy Centers

Astragalus Polysaccharides/Chitosan Microspheres for Nasal Delivery: Preparation, Optimization, Characterization, and Pharmacodynamics

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