Clinical Pharmacology of Other Drugs Used as Hypnotics

Buysse, Daniel J.

doi:10.1016/b978-1-4160-6645-3.00043-8

Cited by 4 publications

References 170 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Pharmacological Treatment of Sleep Disorders and Its Relationship with Neuroplasticity

Abad

Guilleminault

2015

Sleep, Neuronal Plasticity and Brain Function

View full text Add to dashboard Cite

Sleep and wakefulness are regulated by complex brain circuits located in the brain stem, thalamus, subthalamus, hypothalamus, basal forebrain, and cerebral cortex. Wakefulness and NREM and REM sleep are modulated by the interactions between neurotransmitters that promote arousal and neurotransmitters that promote sleep. Various lines of evidence suggest that sleep disorders may negatively affect neuronal plasticity and cognitive function. Pharmacological treatments may alleviate these effects but may also have adverse side effects by themselves. This chapter discusses the relationship between sleep disorders, pharmacological treatments, and brain plasticity, including the treatment of insomnia, hypersomnias such as narcolepsy, restless legs syndrome (RLS), obstructive sleep apnea (OSA), and parasomnias.

show abstract

Pharmacological Treatment of Sleep Disorders and Its Relationship with Neuroplasticity

Abad

Guilleminault

2015

Sleep, Neuronal Plasticity and Brain Function

View full text Add to dashboard Cite

show abstract

Sleep, Slow-Wave Sleep, and Blood Pressure

Javaheri

Redline

2012

Curr Hypertens Rep

View full text Add to dashboard Cite

There is increasing evidence that alterations in sleep continuity due to central nervous system arousal and/or reductions in deeper stages of sleep adversely affect blood pressure and contribute to hypertension. Disturbed sleep also blunts the normal nocturnal dip in blood pressure and may lead to sustained daytime hypertension as well. Nocturnal drops in blood pressure result from increased parasympathetic and reduced sympathetic activity during sleep. Slow-wave sleep, considered to be the most "restorative," is the specific sleep state associated with the largest decline in sympathetic activity. The time in slow-wave sleep declines with age as well as in association with other health problems. A reduction in the time in slow-wave sleep has recently been reported to predict increased incident hypertension. The mechanisms by which this occurs have not been well described but may include alterations in dipping patterns, sympathetic nervous system activity, corticotrophin pathways, and the renin-angiotensin system. This article reviews the overall association between sleep and hypertension, with a specific focus on slow-wave sleep, a possible novel target for future blood pressure interventions.

show abstract