Pharmacological Treatment of Sleep Disorders and Its Relationship with Neuroplasticity

Abad, Vivien C.; Guilleminault, Christian

doi:10.1007/7854_2014_365

Cited by 13 publications

(6 citation statements)

References 229 publications

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“…Obstructive sleep apnea (OSA) is a condition in which the upper airway is obstructed during sleep, producing arousals from sleep and excessive daytime somnolence. OSA is associated with cardiovascular disease and other comorbidities, and may result in cognitive and performance deficits, such as difficulties with cognitive processing, sustaining attention, memory, and executive function [1][2][3][4]. One of the major presenting symptoms of OSA is excessive daytime sleepiness (EDS), which has the potential to significantly impair a patient's healthrelated quality of life (HRQOL), including daily functioning [5][6][7], physical health and functioning [8,9], emotional well-being [6,9], social life [10], and cognition [11].…”

Section: Introductionmentioning

confidence: 99%

Understanding the burden of illness of excessive daytime sleepiness associated with obstructive sleep apnea: a qualitative study

Waldman

Parthasarathy

Villa

et al. 2020

Health Qual Life Outcomes

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Background Obstructive sleep apnea (OSA) is associated with excessive daytime sleepiness (EDS), which may go undiagnosed and can significantly impair a patient’s health-related quality of life (HRQOL). This qualitative research examined timing and reasons patients sought medical care for their EDS and OSA symptoms, and the impact of EDS on HRQOL. Methods Focus groups were conducted in 3 US cities with 42 participants currently experiencing EDS with OSA. Transcripts were coded and analyzed using an adapted grounded theory approach common to qualitative research. Results Over three-fifths of study participants (n = 26, 62%) were currently using a positive airway pressure (PAP) or dental device; one-third (n = 14, 33%) had previously used a positive airway pressure (PAP) or dental device, and the remainder had either used another treatment (n = 1, 2%) or were treatment naïve (n = 1, 2%). Twenty-two participants (52%) reported experiencing OSA symptoms for ≥1 year, with an average duration of 11.4 (median 8.0, range 1–37) years before seeking medical attention. Several (n = 7, 32%) considered their symptoms to be “normal,” rather than signaling a serious medical condition. Thirty participants (71%) discussed their reasons for ultimately seeking medical attention, which included: input from spouse/partner, another family member, or friend (n = 20, 67%); their own concern about particular symptoms (n = 7, 23%); and/or falling asleep while driving (n = 5, 17%). For all 42 participants, HRQOL domains impacted by EDS included: physical health and functioning (n = 40, 95%); work productivity (n = 38, 90%); daily life functioning (n = 39, 93%); cognition (n = 38, 90%); social life/relationships (n = 37, 88%); and emotions (n = 30, 71%). Conclusions Findings suggest that patients may be unaware that their symptoms could indicate OSA requiring evaluation and treatment. Even following diagnosis, EDS associated with OSA can continue to substantially affect HRQOL and daily functioning. Further research is needed to address diagnostic delays and unmet treatment needs for patients with EDS associated with OSA.

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Section: Introductionmentioning

confidence: 99%

Understanding the burden of illness of excessive daytime sleepiness associated with obstructive sleep apnea: a qualitative study

Waldman

Parthasarathy

Villa

et al. 2020

Health Qual Life Outcomes

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“…The used compounds have, independently, potential central nervous system side effects that can limit to varying degrees the functional capacities of the individual. The most common are fatigue, lethargy, somnolence, dizziness, unsteadiness, visual impairment, headache, postural hypotension, weight gain, psychomotor impairment, cognitive impairment, confusion, mood disorders, emotional lability, and even personality changes [ 79 , 80 , 81 , 82 , 83 , 84 , 85 ]. Moreover, combining two or more drugs places the patient in a grey zone where it becomes quite difficult to determine her/his real neurological potential and the actual disease-related symptoms.…”

Section: The Promised Revolution Of New Technologies: a Real Opportun...mentioning

confidence: 99%

After 55 Years of Neurorehabilitation, What Is the Plan?

Viruega¹,

Gaviria²

2022

Brain Sciences

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Neurological disorders often cause severe long-term disabilities with substantial activity limitations and participation restrictions such as community integration, family functioning, employment, social interaction and participation. Increasing understanding of brain functioning has opened new perspectives for more integrative interventions, boosting the intrinsic central nervous system neuroplastic capabilities in order to achieve efficient behavioral restitution. Neurorehabilitation must take into account the many aspects of the individual through a comprehensive analysis of actual and potential cognitive, behavioral, emotional and physical skills, while increasing awareness and understanding of the new self of the person being dealt with. The exclusive adoption by the rehabilitator of objective functional measures often overlooks the values and goals of the disabled person. Indeed, each individual has their own rhythm, unique life history and personality construct. In this challenging context, it is essential to deepen the assessment through subjective measures, which more adequately reflect the patient’s perspective in order to shape genuinely tailored instead of standardized neurorehabilitation approaches. In this overly complex panorama, where confounding and prognostic factors also strongly influence potential functional recovery, the healthcare community needs to rethink neurorehabilitation formats.

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“…Sleep promotion interventions include both pharmacological and non-pharmacological treatments. Pharmacological agents that induce sleep provide sedation and analgesia and are commonly used in the ICU setting ( 7 ). However, pharmacological interventions can have negative side effects such as impaired cognitive function, the risk of tolerance or dependency, decreased ventilation, and a disruption in normal sleep physiology ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Eye Masks and Earplugs Interventions for Sleep Promotion in Critically Ill Patients: A Systematic Review and Meta-Analysis

et al. 2021

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Using physical devices such as eye masks and earplugs to improve to the quality of sleep in intensive care units (ICUs) is a very important issue. This study was conducted to assess the efficacy of eye masks and earplugs for sleep promotion in critically ill adult patients in the ICU based on various sleep quality assessment tools. PubMed, Scopus, Web of Science, and ProQuest were systematically retrieved until May 2021. Both randomized and non-randomized experimental and quasi-experimental studies were included if they evaluated the efficacy of eye masks and earplugs interventions on sleep outcomes in critically ill patients. The methodological quality was assessed by the Joanna Briggs Institute (JBI) critical appraisal tool. For the main outcome (sleep quality), a mean difference (MD) and confidence intervals (CIs) of 95% were determined. A total of 2,687 participants from 35 studies met the inclusion criteria. Twenty one studies were included in meta-analysis and 14 studies were included in the qualitative analysis. According to the results based on sleep quality assessment tools; overall scores of Pittsburgh Sleep Quality Index (PSQI) and Richards-Campbell Sleep Questionnaire (RCSQ), eye mask and/or earplug interventions have a positive effect on sleep quality. Based on Verran-Snyder-Halpern Sleep Scale (VSHSS), sleep disturbance was significantly lower in the intervention groups. In terms of polysomnography, the use of eye masks and/or earplugs resulted in a significant increase in total sleep time, sleep efficiency, rapid eye movement (REM) time, significant reduction of awaking, and sleep arousals index. The results of the present study suggest that the use of earplugs or eye masks, separately or combined affects sleep improvement in critically ill patients.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=145830, PROSPERO: CRD42020145830.

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Pharmacological Treatment of Sleep Disorders and Its Relationship with Neuroplasticity

Cited by 13 publications

References 229 publications

Understanding the burden of illness of excessive daytime sleepiness associated with obstructive sleep apnea: a qualitative study

Understanding the burden of illness of excessive daytime sleepiness associated with obstructive sleep apnea: a qualitative study

After 55 Years of Neurorehabilitation, What Is the Plan?

The Efficacy of Eye Masks and Earplugs Interventions for Sleep Promotion in Critically Ill Patients: A Systematic Review and Meta-Analysis

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