Clinical Pharmacology of MAO Inhibitors: Safety and Future

Yamada, Mitsuhiko; Yasuhara, Hajime

doi:10.1016/s0161-813x(03)00097-4

Cited by 293 publications

(167 citation statements)

References 34 publications

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“…9,25,38 The statistically significant reductions in BPRS-AD scores from D1 to D21 suggest that AYA produced antidepressive and anxiolytic effects. A previous study reported decreased panic-related signs after acute AYA intake.…”

Section: Discussionmentioning

confidence: 98%

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Osório

Sanches

Macedo

et al. 2015

Rev. Bras. Psiquiatr.

359

292

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Objectives: Ayahuasca (AYA), a natural psychedelic brew prepared from Amazonian plants and rich in dimethyltryptamine (DMT) and harmine, causes effects of subjective well-being and may therefore have antidepressant actions. This study sought to evaluate the effects of a single dose of AYA in six volunteers with a current depressive episode. Methods: Open-label trial conducted in an inpatient psychiatric unit. Results: Statistically significant reductions of up to 82% in depressive scores were observed between baseline and 1, 7, and 21 days after AYA administration, as measured on the Hamilton Rating Scale for Depression (HAM-D), the Montgomery-Å sberg Depression Rating Scale (MADRS), and the Anxious-Depression subscale of the Brief Psychiatric Rating Scale (BPRS). AYA administration resulted in nonsignificant changes in Young Mania Rating Scale (YMRS) scores and in the thinking disorder subscale of the BPRS, suggesting that AYA does not induce episodes of mania and/or hypomania in patients with mood disorders and that modifications in thought content, which could indicate psychedelic effects, are not essential for mood improvement. Conclusions: These results suggest that AYA has fast-acting anxiolytic and antidepressant effects in patients with a depressive disorder.

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Section: Discussionmentioning

confidence: 98%

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Osório

Sanches

Macedo

et al. 2015

Rev. Bras. Psiquiatr.

359

292

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“…Certain novel pyrazole derivatives as dual MAO inhibitors and anti-inflammatory analgesics (148) are also a novel therapeutic approach in AD. Thus, selective MAO inhibitors may be a promising alternative for AD therapy.…”

Section: Evidence For the Neuroprotective Effect Of Mao Inhibitors In Admentioning

confidence: 99%

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer’s disease (Review)

Cai

2014

Molecular Medicine Reports

154

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Abstract. Activated monoamine oxidase (MAO) has a critical role in the pathogenesis of Alzheimer's disease (AD), including the formation of amyloid plaques from amyloid β peptide (Aβ) production and accumulation, formation of neurofibrillary tangles, and cognitive impairment via the destruction of cholinergic neurons and disorder of the cholinergic system. Several studies have indicated that MAO inhibitors improve cognitive deficits and reverse Aβ pathology by modulating proteolytic cleavage of amyloid precursor protein and decreasing Aβ protein fragments. Thus, MAO inhibitors may be considered as promising therapeutic agents for AD.

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“…These enzymes are responsible for the oxidative deamination of endogenous and xenobiotic amines. They have different substrate preference, inhibitor specificity and tissue distributions 6 . Tyramine is a substrate for both MAO-A and MAO-B.…”

Section: Introductionmentioning

confidence: 99%

“…While the classic non-selective and irreversible MAOIs, such as phenelzine and tranylcypromine, are characterized by the risk of inducing a hypertensive crisis when dietary tyramine is ingested, the selective MAO-B inhibitor selegiline and the selective and reversible inhibitor of MAO-A (RIMA) moclobemide are free from this potential interaction 5,6 . Alzheimer's disease has been linked with this mechanism, that is, increased MAO-B activity plus reduced free radical scavenging capacity.…”

Section: Introductionmentioning

confidence: 99%

Total monoamine oxidase (MAO) inhibition by chestnut honey, pollen and propolis

Yıldız

Karahalil

Can

et al. 2013

Journal of Enzyme Inhibition and Medicinal Chemistry

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Monoamine oxidase (MAO) inhibitors are generally used in the treatment of depressive disorders and some neurodegenerative illnesses, such as Parkinson's disease and Alzheimer's disease. The aim of this preliminary study was to investigate the MAO [MAO (E.C.1.4.3.4)] inhibiting effect of various apitherapeutic products, such as chestnut honey, pollen and propolis. Extracts' MAO inhibition was measured using peroxidase-linked spectrophotometric assay in enzyme isolated from rat liver microsomes, and the values are expressed as the inhibition concentration (IC 50 ) causing 50% inhibition of MAO. The antioxidant activity of the bee products was also determined in terms of total phenolic content (TPC) and ferric reducing/ antioxidant power in aquatic extracts. All samples exhibited substantial inhibition of MAO, propolis having the highest. Inhibition was related to samples' TPCs and antioxidant capacities. These results show that bee products possess a sedative effect and may be effective in protecting humans against depression and similar diseases.

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Clinical Pharmacology of MAO Inhibitors: Safety and Future

Cited by 293 publications

References 34 publications

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Antidepressant effects of a single dose of ayahuasca in patients with recurrent depression: a preliminary report

Monoamine oxidase inhibitors: Promising therapeutic agents for Alzheimer’s disease (Review)

Total monoamine oxidase (MAO) inhibition by chestnut honey, pollen and propolis

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