Clinical periodontal, bacterial, and immunological outcomes of antimicrobial photodynamic therapy in orthodontic treatment-induced gingival enlargement

Alshahrani, Abdulaziz; Togoo, Rafi Ahmad; Kamran, Muhammad Abdullah; Alshahrani, Ibrahim

doi:10.1016/j.pdpdt.2020.101934

Cited by 8 publications

(9 citation statements)

References 30 publications

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“…La HG puede tener un origen genético o presentarse como una entidad patológica idiopática. Esta patología, también, se ha descrito en pacientes con ingesta prolongada de medicamentos como los bloqueadores de calcio, anticonvulsivantes, inmunosupresores e, incluso, en pacientes portadores de tratamiento ortodóntico (14)(15)(16). Otros reportes describen…”

Section: Discussionunclassified

Diferencias fenotípicas de fibroblastos gingivales en sujetos con hiperplasia gingival idiopática frente a sujetos periodontalmente sanos: estudio piloto

Simancas-Escorcia,

Díaz–Caballero,

Vergara–Hernández

2021

Acta Odontol. Colomb.

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Objetivo: identificar, describir y diferenciar las características fenotípicas de los fibroblastos gingivales (FGs) en pacientes con hiperplasia gingival idiopática (HGI) e individuos periodontalmente sanos. Métodos: los FGs fueron aislados a partir de tejido gingival de individuos periodontalmente sanos (n=2) y pacientes con HGI (n=2). Los FGs se cultivaron en el medio DMEM (Dulbecco's Modified of Eagle Medium) a 37°C con 5% de CO2. La identificación y localización de la actina, vimentina y mitocondrias en FGs fue realizada y evaluada microscópicamente mediante inmunofluorescencia con anticuerpos monoclonales. La capacidad de migración de los FGs en los pacientes con HGI e individuos sanos también fue estudiada. Resultados: todos los FGs fueron mononucleares, fusiformes y con prolongaciones citoplasmáticas visibles. La faloidina permitió identificar una densa red de actina en los FGs de pacientes con HGI, contrariamente a los FGs de individuos periodontalmente sanos. La vimentina y mitocondrias fueron identificadas en los FGs de individuos sanos y pacientes con HGI sin ninguna alteración en su expresión y localización. La migración de la monocapa de los FGs indicó una actividad de migración celular importante en los FGs de los pacientes con HGI, en relación a los FGs de los individuos periodontalmente sanos. Conclusión: los FGs de pacientes con HGI conservan características fenotípicas celulares similares a los FGs de individuos periodontalmente sanos. Sin embargo, los FGs de pacientes con HGI simulan tener una mayor capacidad migratoria que amerita ser explorada en futuros trabajos de investigación.

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Section: Discussionunclassified

Diferencias fenotípicas de fibroblastos gingivales en sujetos con hiperplasia gingival idiopática frente a sujetos periodontalmente sanos: estudio piloto

Simancas-Escorcia,

Díaz–Caballero,

Vergara–Hernández

2021

Acta Odontol. Colomb.

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“…While Baeshan HA [16] et al and Nazeh AA et al [17] studies showed some concerns with respect to selection of the reported results and information on missing outcome data. Studies by Alshahrani A et al [18] and Kamran MA et al [19] had an overall score of 6 and 7 respectively due to inconsistencies in the assessment of outcomes, adequacies to follow up of cohorts and demonstration of outcome at the start of the study. ------------2) Was follow-up long enough for outcomes to occur * * ------------No.…”

Section: Risk Of Bias/ Quality Assessmentmentioning

confidence: 99%

Efficacy of Antimicrobial Photodynamic Therapy as an adjunct periodontal intervention in periodontally diseased subjects undergoing orthodontic therapy

Murugan,

Serab Husain

2024

IJOrthoR

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Photodynamic therapy in fixed orthodontic patients with gingival disease might be beneficial, being non-invasive and having accessibility to difficulty to reach areas like, interdental region with the presence of wires and brackets. This systematic review was designed to analyze the available evidence on the efficacy of antimicrobial photodynamic therapy as an adjunct to scaling in reduction of gingival inflammation in periodontally diseased subjects undergoing fixed orthodontic treatment. Comprehensive search was conducted in electronic databases like PubMed, Scopus and Google scholar along with hand search in relevant journals. Five studies satisfied the criteria and were included in qualitative synthesis of the systematic review. The results of the primary outcome showed adjunctive aPDT did not result in any difference in reduction of gingival inflammation (BOP) compared to scaling alone in fixed orthodontic patients. Only one study showed a significant reduction of gingival inflammation with aPDT, whereas it was better in the scaling group (one study) or no significant difference (3 study) in the other studies. However, aPDT resulted in significant reduction of most of the bacterial species count and proinflammatory cytokine levels in GCF compared to scaling alone. Within the limitations of this systematic review, there is no clear evidence that aPDT adjunctive to scaling has a better effect in reducing gingival inflammation in fixed orthodontic patients. Future studies addressing this area should focus on well planned standardized, long term RCTs that will aid clinicians in making a more evidence - based decision.

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Section: Clinical Trialsmentioning

confidence: 99%

“…In ELISA, IL-1β showed a significant reduction after four weeks of observation for both groups. There were significant differences in the reduced levels of IL-6 between the groups, to the FMPD-PDT group's benefit, after a four-week follow up [29]. Baeshen et al (2020) assessed the effect of PDT on clinical parameters, pain levels, cytokine secretion, and bacterial microflora in adolescent orthodontic patients with gingivitis.…”

Section: Comparison Of Ultrasonic Scaling and Ultrasonic Scaling With Adjunct Antimicrobial Photodynamic Therapymentioning

confidence: 99%

Photodynamic Therapy in Orthodontics: A Literature Review

Olek

Machorowska-Pieniążęk

Stós

et al. 2021

Pharmaceutics

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Treatment of malocclusions using fixed orthodontic appliances makes it difficult for patients to perform hygiene procedures. Insufficient removal of bacterial biofilm can cause enamel demineralization, manifesting by visible white spot lesions or periodontal diseases, such as gingivitis periodontitis or gingival hyperplasia. The classic methods of preventing the above problems include, in addition to proper hygiene, ultrasonic scaling, periodontal debridement, and oral rinses based on chlorhexidine. New alternative methods of reducing plaque around brackets are being developed. There is a growing interest among researchers in the possibility of using photodynamic therapy in orthodontics. A literature search for articles corresponding to the topic of this review was performed using the PubMed and Scopus databases and the following keywords: ‘photodynamic therapy’, ‘orthodontics’, and ‘photosensitizer(s)’. Based on the literature review, two main directions of research can be distinguished: clinical research on the use of photodynamic therapy in the prevention of white spot lesions and periodontal diseases, and ex vivo research using a modified orthodontic adhesive by adding photosensitizers to them. Methylene blue is the most frequently used photosensitizer in clinical trials. The effectiveness of antimicrobial photodynamic therapy is mainly compared to the ultrasonic scaler as a single therapy or as an adjunct to the ultrasonic scaler. In their conclusions, the researchers most often emphasize the effectiveness of antimicrobial photodynamic therapy in reducing microbial levels in patients treated with fixed appliances and the possibility of using it as an alternative to routine procedures aimed at maintaining a healthy periodontium. The authors suggest further research on the use of photodynamic therapy to prove the validity of this method in orthodontics. It should also not be forgotten that proper hygiene is the basis for maintaining oral cavity health, and its neglect is a contraindication to orthodontic treatment.

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Clinical periodontal, bacterial, and immunological outcomes of antimicrobial photodynamic therapy in orthodontic treatment-induced gingival enlargement

Cited by 8 publications

References 30 publications

Diferencias fenotípicas de fibroblastos gingivales en sujetos con hiperplasia gingival idiopática frente a sujetos periodontalmente sanos: estudio piloto

Diferencias fenotípicas de fibroblastos gingivales en sujetos con hiperplasia gingival idiopática frente a sujetos periodontalmente sanos: estudio piloto

Efficacy of Antimicrobial Photodynamic Therapy as an adjunct periodontal intervention in periodontally diseased subjects undergoing orthodontic therapy

Photodynamic Therapy in Orthodontics: A Literature Review

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