Clinical Patterns and Hematological Spectrum in Autoimmune Hemolytic Anemia

Alwar, Vanamala; Devi, AM Shanthala; Sitalakshmi, S; Karuna, RK

doi:10.4103/0974-2727.66703

Cited by 19 publications

(19 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Few studies have compared the clinical and biochemical differences between primary and secondary wAIHA [61619]. In our population, the only statistically significant difference encountered between these two groups was the correlation of a mixed pattern with secondary wAIHA ( P <0.001).…”

Section: Discussionmentioning

confidence: 74%

Warm autoimmune hemolytic anemia: experience from a single referral center in Mexico City

et al. 2017

View full text Add to dashboard Cite

BackgroundAutoimmune hemolytic anemia (AIHA) is characterized by an autoimmune-mediated destruction of red blood cells. Warm AIHA (wAIHA) represents 60% of AIHA cases and is associated with the positive detection of IgG and C3d in the direct antiglobulin test (DAT). This study aimed to assess the clinical and laboratorial differences between primary and secondary wAIHA patients from a referral center in Mexico City.MethodsAll patients diagnosed with wAIHA in our institution from January 1992 to December 2015 were included and received corticosteroids as the first-line treatment. We analyzed the response to the first-line treatment, relapse-free survival, and time to splenectomy.ResultsEighty-nine patients were included. Secondary wAIHA represented 55.1% of the cases. At diagnosis, secondary wAIHA patients showed a DAT mixed pattern more frequently than primary wAIHA patients (36.7 vs. 17.5%, P<0.001). In the survival analysis, patients with secondary wAIHA had a lower time to response (18 vs. 37 days, P=0.05), median disease-free survival (28.51 vs. 50.95 weeks, P=0.018), and time to splenectomy (43.5 vs. 61 wks, P=0.029) than those with primary wAIHA. Due to economic constraints, rituximab was considered as the third-line treatment in only two patients.ConclusionSecondary wAIHA may benefit from a longer low-dose steroid maintenance period mainly due to its shorter time to relapse and time to splenectomy than primary wAIHA.

show abstract

Section: Discussionmentioning

confidence: 74%

Warm autoimmune hemolytic anemia: experience from a single referral center in Mexico City

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Similar finding but with different approach, Hirano et al reported that more than 138 IgG molecules per RBC in AIHA patients can render the direct Coombs test distinctly positive (Hirano et al , ). Various reasons have been given to explain Coombs negativity in AIHA (Lin et al , ; Alwar et al , ; Segel & Lichtman, ). Firstly, the number of IgG sensitised red cells may be below the detection threshold by direct Coombs test.…”

Section: Discussionmentioning

confidence: 99%

Significances of red cell bound immunoglobulin G as detected by flow cytometry in patients with Coombs‐negative immune hemolysis

Thedsawad

Taka

Wanachiwanawin

2016

Transfusion Medicine

View full text Add to dashboard Cite

show abstract

“…Other studies in India have reported the frequency of secondary AIHA as 77% and 29%. (8,9) Baek et al have observed that majority of patients with primary AIHA were found to have SLE during a followup of two years. (10) In the present study, fragmentation hemolysis represented the most frequent form of non-immune acquired hemolytic anemia.…”

Section: Discussionmentioning

confidence: 99%

Acquired Hemolytic Anemia

Veda¹,

Srinivasamurthy²,

Pushpalatha³

2015

jebmh

View full text Add to dashboard Cite

Acquired hemolytic anemia is a group of disorders in which premature destruction of red cells is triggered by extrinsic factors. In this study, we have evaluated 38 cases of acquired hemolytic anemia. Immune hemolysis accounted for 52.6% (n=20) and fragmentation hemolysis 44.7% (n=17) of acquired hemolytic anemia. Autoimmune hemolytic anemia (AIHA) and microangiopathic hemolytic anemia (MHA) surfaced as the two most frequent causes accounting for 44.7% (n=17) and 39.5% (n=15) of acquired hemolysis. Erythrocyte morphology gives valuable clues concerning the cause of hemolysis. Spherocytes were observed in 94% (n=16) cases of immune hemolytic anemia. Schistocytes were observed in all cases of microangiopathic hemolytic anemia (MHA). In addition to schistocytes, microspherocytes were seen in 40% of MHA. Precise identification of spherocytes, schistocytes and microspherocytes is very important as it gives valuable information regarding the cause of acquired hemolysis.

show abstract

Clinical Patterns and Hematological Spectrum in Autoimmune Hemolytic Anemia

Cited by 19 publications

References 7 publications

Warm autoimmune hemolytic anemia: experience from a single referral center in Mexico City

Warm autoimmune hemolytic anemia: experience from a single referral center in Mexico City

Significances of red cell bound immunoglobulin G as detected by flow cytometry in patients with Coombs‐negative immune hemolysis

Acquired Hemolytic Anemia

Contact Info

Product

Resources

About