Clinical patterns and characteristics of ankylosing spondylitis in China

Qian, Qingwen; Xu, Xiufeng; He, Hua‐Jun; Ji, Hengdong; Zhang, Hui; Ding, Yue; Dai, Sheng‐Ming; Zou, Ying; Zhu, Qi; Yang, Chengde; Ye, Shuang; Jiang, Lindi; Tang, Jian; Tong, Qiang; He, Dongyi; Zhao, Dongbao; Li, Yuan; Ma, Yanyun; Zhou, Jingru; Yuan, Ziyu; Zhang, Juan; Jin, Li; Zhou, Xiaodong; Reveille, John D.; Zou, Hejian; Wang, Jiucun

doi:10.1007/s10067-017-3660-3

Cited by 27 publications

(46 citation statements)

References 34 publications

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“…Ankylosing spondylitis (AS) is regarded as the disease prototype, and it typically affects patients at a young age. In a multicenter cross-sectional survey in China, the mean age of onset and diagnosis of AS was 29.2 and 33.5 years respectively [5]. Studies have shown that AS patients have a greater work disability (WD) compared to the general population, with WD rates varying from 3 to 50% in western countries [6–8].…”

Section: Introductionmentioning

confidence: 99%

Psychometric validation of the EuroQoL 5-dimension (EQ-5D) questionnaire in patients with spondyloarthritis

et al. 2019

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BackgroundSpondyloarthritis (SpA) has a significant impact on patients’ quality of life due to functional impairments. Generic health instruments like the EuroQoL 5-dimension (EQ-5D) is important for the cost-utility analysis of health care interventions and calculation of quality-adjusted life years. However, the applicability of the EQ-5D health measure in Chinese patients with SpA is currently unknown. Hence, the aim of the study is to test the psychometric properties and to validate the use of the EQ-5D health measure for utility analyses in Chinese patients with SpA.MethodsProspective and consecutive recruitment of 220 Chinese patients with SpA was conducted. Demographic data including smoking and drinking habits, education level, income, and occupation was collected. Disease-associated data including disease duration, the presence of back pain, peripheral arthritis, dactylitis, enthesitis, uveitis, psoriasis, and inflammatory bowel disease was also recorded. Questionnaires regarding disease activity and functional disability (BASDAI, BASFI, BASGI, BASMI, ASDAS, ODI), mental health (HADS depression and anxiety), and the EQ-5D scores were recorded. SF-36 scores were used to verify the findings. Baseline correlations were performed along with test-retest reliability, validity, and internal consistency tests. Specifically, the relationship between EQ-5D and disease activity and functional scores was studied.ResultsEQ-5D scores achieved acceptable internal consistency and reliability. A ceiling effect was observed for all domains of the EQ-5D except for pain/discomfort. No floor effect was observed. Significant negative correlations were observed between ODI, HADS, BASFI, BASMI, BASDAI, and ASDAS-CRP and with EQ-5D. A higher disease activity was well-differentiated by EQ-5D, as with the disability and mental health scores.ConclusionsThe EQ-5D demonstrates satisfactory psychometric properties for assessment of SpA patients. It has high utility for demonstrating changes in disease activity and disability.

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Section: Introductionmentioning

confidence: 99%

Psychometric validation of the EuroQoL 5-dimension (EQ-5D) questionnaire in patients with spondyloarthritis

et al. 2019

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“…Aydin et al [ 37 ] suggested that bone loss in male AS patients might be related to the level of dehydroepiandrosterone sulfate. Although AS is also considered to be an autoimmune disease, it often occurs in males [ 15 , 16 ] Giltay et al [ 22 ] found that serum testosterone levels of AS patients often did not increase. Studies have also found that the relevant sex steroid hormones cannot directly explain the male predominance in AS, nor its sex-associated characteristics [ 23 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

“…Qian et al found that the male-female ratio of patients with AS was 2.7: 1, and men were more likely to be hla-b27 carriers than women, with a higher level of c-reactive protein (CRP). Other researchers have suggested that the incidence of spinal cord changes is higher in male patients with AS, and their radiological progression is faster, while women may have more peripheral arthritis [ 16 – 19 ]. In addition, the effect of drugs on the treatment of AS is sex-dependent [ 19 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

A Mechanism Underlying Sex-Associated Differences in Ankylosing Spondylitis: Troponin C2, Fast Skeletal Type (TNNC2) and Calcium Signaling Pathway

Zhan

Liu

et al. 2020

Med Sci Monit

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Background Ankylosing spondylitis (AS) is a disease that causes pathological changes in the spine and sacroiliac joints. Numerous studies have shown that the characteristics of AS differ between males and females. The purpose of this study was to discover the key molecules that contribute to sex-associated differences in AS, which may provide a new molecular target for personalized treatment. Material/Methods The gene expression profile of GSE39340 was downloaded from the Gene Expression Comprehensive database, and 2 groups (AS vs. No-AS groups and male AS vs. female AS groups) of differentially expressed genes (EDGs) were obtained by GEO2R. The DAVID database was used for DEGs function and enrichment analysis. Based on data in the STRING online database, a protein–protein interaction (PPI) network was constructed in Cytoscape. Hub genes were selected from CytoHubba. With the intersection of the top 30 hub genes of 2 sets of EDGs, genes coexisting with the KEGG-related pathway were found. Results We screened 560 genes between the AS and No-AS groups, and screened 710 genes that were differentially expressed between the male and female AS groups. GO analysis showed that DEGs were mainly co-enriched in molecular functions, including structural constituent of muscle. The KEGG pathway mainly included the structural constituent of muscle. Seven hub genes were obtained. Troponin C2 and fast skeletal type (TNNC2) were the key genes participating in the calcium signaling pathway. Conclusions This study contributes to understanding the molecular biological mechanism underlying sex-associated differences in AS. TNNC2 and calcium signaling pathway may be new targets for the individualized treatment of AS.

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“…In 2017, a study enrolled 1251 AS patients from China. e results showed that the mean age of onset and diagnosis was 29.2 and 33.5 years, and the ratio of male to female was 2.7 : 1 [4]. A recent study reported that the risk of cardiovascular events in AS patients increased by 30-50% compared with the general population [5].…”

Section: Introductionmentioning

confidence: 89%

The Efficacy and Safety of Simple‐Needling Therapy for Treating Ankylosing Spondylitis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Xuan

Huang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Clinical investigators have found that the use of needling in the treatment of ankylosing spondylitis (AS) has a good clinical application prospect in recent years. However, these studies were insufficient to provide evidence for the efficacy and safety of simple-needling for AS. So, we performed a systematic review and meta-analysis to evaluate the efficacy and safety of simple-needling for treating AS. Methods. We searched the PubMed, Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Literature Database (CBM), Wangfang database (Wanfang), Chinese Science and Technology Periodical Database (VIP), and any other gray literature sources for randomized controlled trials (RCTs) that used simple-needling to treat AS before June 2019 with the language restriction of Chinese and English. Researchers evaluated the retrieved literature studies and extracted valid data according to relevant requirements and used RevMan5.3 software for meta-analysis. Results. A total of 10 studies were included, all of which were Chinese literature studies, involving 729 patients. Compared with the control groups, simple-needling groups had a better effect on the clinical effective rate (RR = 1.20, 95% CI (1.11, 1.29), P<0.00001), TCM syndrome score (MD = −5.26, 95% CI (−5.99, −4.53), P<0.00001), symptom score (MD = −8.08, 95% CI (−10.18, −5.97), P<0.00001), and Schober test outcome (MD = 0.39, 95% CI (0.15, 0.64), P=0.002). Sensibility analysis was based on the leave-one-out cross-validation procedure, and the results showed no significant changes. Most studies did not describe adverse reactions. The funnel plot suggested publication bias on clinical effectiveness. Conclusions. This systematic review and meta-analysis demonstrated that simple-needling was effective as an intervention for AS. However, due to the low quality of the methodology of included studies, the designs of clinical trials were not rigorously standardized. Therefore, it is necessary to carry out multiquality RCTs for verification.

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Clinical patterns and characteristics of ankylosing spondylitis in China

Cited by 27 publications

References 34 publications

Psychometric validation of the EuroQoL 5-dimension (EQ-5D) questionnaire in patients with spondyloarthritis

Psychometric validation of the EuroQoL 5-dimension (EQ-5D) questionnaire in patients with spondyloarthritis

A Mechanism Underlying Sex-Associated Differences in Ankylosing Spondylitis: Troponin C2, Fast Skeletal Type (TNNC2) and Calcium Signaling Pathway

The Efficacy and Safety of Simple‐Needling Therapy for Treating Ankylosing Spondylitis: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

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