Psychometric validation of the EuroQoL 5-dimension (EQ-5D) questionnaire in patients with spondyloarthritis

Abstract

BackgroundSpondyloarthritis (SpA) has a significant impact on patients’ quality of life due to functional impairments. Generic health instruments like the EuroQoL 5-dimension (EQ-5D) is important for the cost-utility analysis of health care interventions and calculation of quality-adjusted life years. However, the applicability of the EQ-5D health measure in Chinese patients with SpA is currently unknown. Hence, the aim of the study is to test the psychometric properties and to validate the use of the EQ-5D health measure for utility analyses in Chinese patients with SpA.MethodsProspective and consecutive recruitment of 220 Chinese patients with SpA was conducted. Demographic data including smoking and drinking habits, education level, income, and occupation was collected. Disease-associated data including disease duration, the presence of back pain, peripheral arthritis, dactylitis, enthesitis, uveitis, psoriasis, and inflammatory bowel disease was also recorded. Questionnaires regarding disease activity and functional disability (BASDAI, BASFI, BASGI, BASMI, ASDAS, ODI), mental health (HADS depression and anxiety), and the EQ-5D scores were recorded. SF-36 scores were used to verify the findings. Baseline correlations were performed along with test-retest reliability, validity, and internal consistency tests. Specifically, the relationship between EQ-5D and disease activity and functional scores was studied.ResultsEQ-5D scores achieved acceptable internal consistency and reliability. A ceiling effect was observed for all domains of the EQ-5D except for pain/discomfort. No floor effect was observed. Significant negative correlations were observed between ODI, HADS, BASFI, BASMI, BASDAI, and ASDAS-CRP and with EQ-5D. A higher disease activity was well-differentiated by EQ-5D, as with the disability and mental health scores.ConclusionsThe EQ-5D demonstrates satisfactory psychometric properties for assessment of SpA patients. It has high utility for demonstrating changes in disease activity and disability.

Standardizing Health Outcomes for Lung Cancer. Adaptation of the International Consortium for Health Outcomes Measurement Set to the Spanish Setting

“…The ICHOM proposed instruments to measure patient-reported health status [EORTC-QLQ-C30 ( 24 ) and the LC specific version QLQ-LC13 ( 25 )] were not deemed appropriate in the Spanish setting, as they are burdensome to complete and their use is limited in routine clinical practice. Instead, consensus was reached to use the generic questionnaire EuroQol EQ-5D ( 26 , 27 ), that is currently widely used in the Spanish setting, and the LC specific questionnaire Lung Cancer Symptom Scale (LCSS) ( 28 ), for which a Spanish validated version is already available. The combined use of both questionnaires allows to gather information about patient perspective on their physical and emotional functioning, fatigue, vitality, pain, cough, breathing difficulty, hemoptysis, and loss of appetite.…”

“…Therefore, and in line with ICHOM recommendations, it was agreed to collect both variables at baseline and during patients' follow up. As previously indicated, ECOG scale ( 23 ) was selected to assess patients' performance status, while the EQ-5D ( 26 , 27 ) and LCSS questionnaire ( 28 ) were chosen for the assessment of patients' HRQoL.…”

The incidence of bone marrow oedema at the sacroiliac joints in a non-rheumatological population — a retrospective cohort study

“…In 1990, the EuroQol group developed a health-related quality of life questionnaire (EQ-5D) consisting of five dimensions (mobility, self-care, main activities, social relationships, pain and mood) and an EQ visual analogue scale (score 0–100) to be used for describing a non-disease specific health status (14). Studies on patients with SpA have shown a negative correlation between EuroQol and SpA disease activity scores, such as BASDAI and ASDAS (15–16).…”

Measurement Properties of Commonly Used Generic Preference-Based Measures in East and South-East Asia: A Systematic Review

“…Test-retest reliability Responsiveness China + H [21, 27, 28, 41-43, 45, 57, 72, 75, 76, 82, 83, 85, 87, 89, 90] ± H [27,41,75] Hong Kong + H [17,18,20,70,79] ± L b [20,70,79] SF-6D and EQ-VAS, and to explore ways to improve their performance in Asian populations. This study has three limitations.…”