Clinical Pattern and Outcome of Organophosphorus Compound Poisoning

Acetylcholinesterase (AChE) is the key enzyme responsible for deactivating the ACh neurotransmitter. Irreversible or prolonged inhibition of AChE, therefore, elevates synaptic ACh leading to serious central and peripheral adverse effects which fall under the cholinergic syndrome spectra. To combat the toxic effects of some AChEI, such as organophosphorus (OP) nerve agents, many compounds with reactivator effects have been developed. Within the most outstanding reactivators, the substances denominated oximes stand out, showing good performance for reactivating AChE and restoring the normal synaptic acetylcholine (ACh) levels. This review was developed with the purpose of covering the new advances in AChE reactivation. Over the past years, researchers worldwide have made efforts to identify and develop novel active molecules. These researches have been moving farther into the search for novel agents that possess better effectiveness of reactivation and broad-spectrum reactivation against diverse OP agents. In addition, the discovery of ways to restore AChE in the aged form is also of great importance. This review will allow us to evaluate the major advances made in the discovery of new acetylcholinesterase reactivators by reviewing all patents published between 2016 and 2019. This is an important step in continuing this remarkable research so that new studies can begin.

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THE OBSERVATIONAL & CROSS-SECTIONAL STUDY OF CLINICAL PATTERN AND OUTCOME OF ORGANOPHOSPHORUS POISONING AT MGM MEDICAL COLLEGE AND HOSPITAL, JAMSHEDPUR, JHARKHAND

Pandey

Dorai

Sarkar³

et al. 2020

ijsr

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OBJECTIVES: To study the clinical presentation and outcome of acute organophosphorus(OP) poisoning. METHODS: This case series included 94 cases from medical wards/emergency/I.C.U. of MGM Medical College, Jamshedpur, Jharkhand from March 2019 to February 2020. all patients of organophosphorus poisoning showing either sign of muscarinic or nicotinic effects were included. We did exclude those patients with doubtful poisoning. RESULTS: Ninety-Four patients with organophosphate poisoning were admitted. Among these 61% were males and 39% were females. Modes of poisoning were suicidal in 61% of cases, accidental in 35%, and 4% were homicidal. The clinical presentation of acute poisoning was variable however the most consistent feature was miosis (98%). As per WHO classification for severity of organophosphorus poisoning; 57% of cases were moderate, 27% were severe, and 16% were mild. The mortality rate was 17% and mostly among patients who presented with severe symptoms and presented late. CONCLUSION: OPs are the main chemical threat to young people, depressed individuals, and farmworkers. so rapid diagnosis and early treatment is essential to save

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Clinical Pattern and Outcome of Organophosphorus Compound Poisoning

Cited by 3 publications

References 8 publications

Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects

Slight difference in the isomeric oximes K206 and K203 makes huge difference for the reactivation of organophosphorus-inhibited AChE: Theoretical and experimental aspects

Trends in the Recent Patent Literature on Cholinesterase Reactivators (2016–2019)

THE OBSERVATIONAL & CROSS-SECTIONAL STUDY OF CLINICAL PATTERN AND OUTCOME OF ORGANOPHOSPHORUS POISONING AT MGM MEDICAL COLLEGE AND HOSPITAL, JAMSHEDPUR, JHARKHAND

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