Clinical, Pathophysiologic, and Microbiologic Characterization of Bronchiectasis in an Aging Cohort

Nicotra, M. Brooke; Rivera, Marisa; Dale, Andrea; Shepherd, Robert D.; Carter, R

doi:10.1378/chest.108.4.955

Cited by 265 publications

(227 citation statements)

References 13 publications

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“…The median age of persons hospitalized with bronchiectasis was significantly higher in women than in men (women, 75 years; men, 71 years). For hospitalizations with bronchiectasis as the primary diagnosis from 2000 to 2006, 57% (14,735) were coded as bronchiectasis with acute exacerbation (494.1), 35% (9,142) were coded as bronchiectasis without acute exacerbation (494.0) and 8% (2,142) were coded as bronchiectasis (494). Among the 35% of hospitalizations States in part because of childhood immunizations and increased use of broad-spectrum antibiotics.…”

Section: Resultsmentioning

confidence: 99%

Trends and Burden of Bronchiectasis-Associated Hospitalizations in the United States, 1993-2006

Seitz

Olivier

Steiner

et al. 2010

Chest

223

162

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Bronchiectasis is a potentially serious condition related to permanent and abnormal widening of the airways. Common characteristics of bronchiectasis include chronic cough, sputum production, hemoptysis, and shortness of breath. [1][2][3] Multiple factors can contribute to bronchiectasis, including chronic lung infection, foreign objects in the airways, and inherited disorders such as cystic fi brosis and primary ciliary dyskinesia. 4 The current epidemiology of bronchiectasis in the United States has not been well described. The only recent US study was a retrospective cohort design with . 56 million patients from multiple US health plans, which used International Classifi cation of Diseases, Ninth Revision, codes to estimate a prevalence of 52.3 cases of bronchiectasis per 100,000 adults. 5 Previous studies have suggested that the incidence among children and the overall prevalence of bronchiectasis may be declining in areas of the United

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Section: Resultsmentioning

confidence: 99%

Trends and Burden of Bronchiectasis-Associated Hospitalizations in the United States, 1993-2006

Seitz

Olivier

Steiner

et al. 2010

Chest

223

162

View full text Add to dashboard Cite

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“…Other common characteristics in these patients include chronic rhinosinusitis that ranges from intermittent nasal discharge to severe purulent sinusitis (present in 70% of patients) and a notable history of ear, nose and throat surgery for recurrent sinusitis (30% of patients) 29. Mild, intermittent haemoptysis occurs in 26%‐51% of cases, but at times it can be severe and life‐threatening 29, 31. Many patients with bronchiectasis require frequent hospital admissions for recurrent pneumonia 29, 31.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Mild, intermittent haemoptysis occurs in 26%‐51% of cases, but at times it can be severe and life‐threatening 29, 31. Many patients with bronchiectasis require frequent hospital admissions for recurrent pneumonia 29, 31. Depression and anxiety are common in patients with bronchiectasis, which may significantly affect their quality of life 32, 33…”

Section: Clinical Presentationmentioning

confidence: 99%

“…Other common findings include rhonchi (44%) and wheezing (21%‐34%) 29, 31. Clubbing of the digits is rare and occurs in 2%‐3% of cases 29, 31…”

Section: Diagnostic Approachmentioning

confidence: 99%

“…In bronchiectasis, the majority of patients present with mild to moderate airway obstruction, with a forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio less than 70, along with an FEV1 >50% predicted 29, 31. Significant bronchodilator response (response of >200 mL and 12% predicted in FEV1 and FVC after administration of β 2 agonists 57) occurs in only 22% of patients with NCFB 29.…”

Section: Diagnostic Approachmentioning

confidence: 99%

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Suspecting non-cystic fibrosis bronchiectasis: What the busy primary care clinician needs to know

et al. 2017

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SummaryAimsNon‐cystic fibrosis bronchiectasis (NCFB) is a chronic, progressive respiratory disorder characterised by irreversibly and abnormally dilated airways, persistent cough, excessive sputum production and recurrent pulmonary infections. In the last several decades, its prevalence has increased, making it likely to be encountered in the primary care setting. The aim was to review the clinical presentation and diagnosis of NCFB, with an emphasis on the role of computed tomography (CT).MethodsFor this review, trials and reports were identified from PubMed/Medline and ClinicalTrials.gov from the US NIH and the Cochrane Register of Controlled Trials. The search used keywords: bronchiectasis, non‐cystic fibrosis bronchiectasis, chronic pulmonary infection and computed tomography. No date/language restrictions were used.ResultsNon‐cystic fibrosis bronchiectasis often coexists with other respiratory conditions, such as chronic obstructive pulmonary disease. The prevalence of NCFB is increasing, particularly in women and older individuals, possibly as a result of increased physician awareness and widespread use of CT, which is the gold standard for the diagnosis of NCFB. CT can assist in identifying an underlying cause of NCFB and determining the extent and severity of the disease.DiscussionNon‐cystic fibrosis bronchiectasis should be suspected in the primary care setting in patients with chronic cough, purulent sputum and frequent respiratory infections that tend to resolve slowly or partially. Early diagnosis and determination of the extent and severity of the disease by CT and other tests are critical to establish therapy to improve quality of life and potentially slow progressive decline of lung function in patients with NCFB .

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Bronchiectasis

Seaton¹

2000

Crofton and Douglas's Respiratory Diseases

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Clinical, Pathophysiologic, and Microbiologic Characterization of Bronchiectasis in an Aging Cohort

Cited by 265 publications

References 13 publications

Trends and Burden of Bronchiectasis-Associated Hospitalizations in the United States, 1993-2006

Trends and Burden of Bronchiectasis-Associated Hospitalizations in the United States, 1993-2006

Suspecting non-cystic fibrosis bronchiectasis: What the busy primary care clinician needs to know

Bronchiectasis

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