Clinical pathology of metastatic gastric carcinoma to the breast: A report of two cases and a review of literature

Qing, Tian; Xueqin, Tao; Zhang, Zhanmin; Zhou, Xiaodong; Wang, Yiting

doi:10.3892/ol.2016.4350

Cited by 12 publications

(12 citation statements)

References 17 publications

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“…Gastric cancer metastases in the breast are mostly of the signet ring cell type and should be distinguished from primary breast signet ring cell carcinomas, which were first described as a subtype of lobular tumors by Steinbrecher and Silverberg in 1976 5 . Primary breast signet ring cell carcinomas have aggressive biological behavior and a higher tendency for metastasis to the abdomen.…”

Section: Discussionmentioning

confidence: 99%

Breast metastasis of gastric signet ring cell carcinoma mimicking breast lymphangitic carcinomatosis

Andrade¹,

Buzzellin²,

Cançado³

et al. 2019

Mastology

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Introdução: A incidência de metástase mamária de adenocarcinoma gástrico é extremamente baixa. De 1908 até o momento, 44 casos foram relatados na literatura, dos quais 30 são do tipo em anel de sinete. Relato do caso: Paciente de 49 anos em propedêutica de sangramento digestivo alto. Apresentava linfadenomegalia axilar esquerda, associada a assimetria mamária, edema e espessamento de pele. Ultrassonografia mamária evidenciou lesão heterogênea em mama esquerda. Histologia de core biopsy da área compatível com adenocarcinoma gástrico tipo difuso de Lauren, com células em anel de sinete. Imuno-histoquímica positiva para pancitoqueratinas CK7, CK20, CDX2 e negativa para RE, RP e ERB2. Achados compatíveis com adenocarcinoma gástrico (embolia linfática), favorecendo a possibilidade de neoplasia secundária. Ao momento do diagnóstico, a paciente já apresentava sinais radiológicos de múltiplas metástases. Discussão: As metástases mamárias do carcinoma gástrico diferem do câncer de mama primário nas características histopatológicas. As manifestações clínicas das metástases de câncer gástrico são variadas, mas é sabido que há tendência maior de alterações inflamatórias que nos tumores primários. No processo metastático, o envolvimento mamário pode ser o primeiro evento ou ocorrer em um contexto polimetastático. A maioria dos pacientes tem sobrevida inferior a RESUMO ABSTRACT Introduction: The incidence of breast metastasis from gastric adenocarcinoma is extremely low. Since 1908, 44 cases have been reported in the literature, of which 30 are signet ring cell type. Case report: A 49-year-old patient being investigated for digestive bleeding was found to have left axillary lymphadenopathy, associated with breast asymmetry, associated with breast asymmetry, edema and thickening of the skin. Breast ultrasonography showed a heterogeneous lesion in the left breast. Core biopsy histology was compatible with Lauren diffuse gastric adenocarcinoma with signet ring cells. There was positive immunohistochemical staining for CK7, CK20 and CDX2 and negative for RE, RP and ERB2. Our findings were compatible with gastric adenocarcinoma (lymphatic embolism), favoring the possibility of a secondary neoplasm. At the time of diagnosis, the patient already had radiological signs of multiple metastases. Discussion: Breast metastases of gastric carcinoma differ from primary breast cancer in histopathological features. The clinical manifestations of gastric cancer metastasis vary, but it is known that there is a greater tendency for inflammatory disorders compared to primary tumors. In the metastatic process, breast involvement may be the first event or occur in a context of multiple metastases. Most patients have a one-year survival after diagnosis. There is no gain in survival with breast surgery, but it can alleviate the symptoms in some cases. Conclusion: Gastric cancer with breast metastasis is a rare condition associated with poor prognosis. The diagnosis is based on clinical history, histological findings and immunohistochemical markers, di...

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Section: Discussionmentioning

confidence: 99%

Breast metastasis of gastric signet ring cell carcinoma mimicking breast lymphangitic carcinomatosis

Andrade¹,

Buzzellin²,

Cançado³

et al. 2019

Mastology

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“…Previous studies reported that only <0.3% of gastric cancer patients develop breast metastasis, which is far less frequent compared with liver metastasis (4-14%), the most common site of distant metastasis from gastric cancer (5,6). Only 16 cases have been reported in China thus far and are summarized in Table I ( [7][8][9][10][11][12][13][14][15][16][17][18][19]. Of those 16 patients, 12 were diagnosed with signet ring cell carcinoma and 5 had multiple metastases.…”

Section: Discussionmentioning

confidence: 99%

“…The majority (10/16) of the Chinese patients with breast metastasis from gastric carcinoma underwent modified radical mastectomy, 4 patients received a lumpectomy, and 2 patients only underwent biopsy. Lumpectomy is the current recommendation for the treatment of such patients (19). Qureshi et al (21) reported that radiotherapy is not effective in treating breast metastases, as it cannot prolong patient survival time.…”

Section: Discussionmentioning

confidence: 99%

Metastatic gastric carcinoma to the breast: Aï¿½caseï¿½report and review of the Chinese literature

Yan

Liu

et al. 2017

mol clin onc

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Abstract. Breast metastasis is extremely unusual in gastric cancer patients worldwide. We herein report the case of a 39-year-old female Chinese patient presenting with symptoms of inflammation in the left breast. A biopsy did not reveal any evidence of malignancy. A modified radical mastectomy was performed and the postoperative pathological examination revealed infiltration by signet ring cell gastric carcinoma. A review of the Chinese literature was performed, and a total of 16 patients with breast metastasis from gastric carcinoma have been reported from 1990 onwards. This condition is associated with a poor prognosis, with a survival time of 1 month to 4 years. More studies are required to determine the optimal treatment.

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“…The breast invasion is the initial manifestation of metastatic disease in 25%-40% of cases (Boutis et al, 2006). Approximately two-thirds of the invasions present in the upper outer quadrant of the breast (Tian et al, 2016). Nipple retraction and nipple discharge are rare while bilateral axillary lymph node involvement can be frequently observed (Akçay, 2002).…”

mentioning

confidence: 99%

Breast metastasis of gastric signet-ring cell carcinoma

Wei

Kong

Zhang

et al. 2017

J. Zhejiang Univ. Sci. B

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Clinical pathology of metastatic gastric carcinoma to the breast: A report of two cases and a review of literature

Cited by 12 publications

References 17 publications

Breast metastasis of gastric signet ring cell carcinoma mimicking breast lymphangitic carcinomatosis

Breast metastasis of gastric signet ring cell carcinoma mimicking breast lymphangitic carcinomatosis

Metastatic gastric carcinoma to the breast: Aï¿½caseï¿½report and review of the Chinese literature

Breast metastasis of gastric signet-ring cell carcinoma

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