Metastatic gastric carcinoma to the breast: Aï¿½caseï¿½report and review of the Chinese literature

Yan, Haiyu; Liu, Jun; Xu, Man; Zhou, Xiaoqian; Jin, Hui; Li, Xiang; Zheng, Mingming

doi:10.3892/mco.2017.1292

Cited by 4 publications

(1 citation statement)

References 9 publications

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“…The reported median overall survival is about 8.6 months [1], with a range of 12 days to 18 months [12]. Early and accurate diagnosis of secondary breast involvement is important for appropriate management and for avoiding unnecessary and potentially harmful treatments of these patients [31-33].…”

Section: Discussionmentioning

confidence: 99%

Breast Metastasis of Gastric Signet Ring Cell Carcinoma: A Case Report and Literature Review

et al. 2021

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Breast metastasis from gastric signet ring cell carcinoma is extremely rare in clinical practice. The estimated incidence is 0.5–1.3%. There are few cases reported in the literature (approx. less than 60) of breast metastasis from gastric signet ring cell carcinoma, and due to the rare association between gastric cancer and its extension to the breast, it is difficult to establish the diagnosis. Clinical history, histological findings, and immunohistochemical markers are helpful in distinguishing primary breast cancer from breast metastasis of gastric cancer. The treatment for breast metastasis from gastric carcinoma remains controversial. The prognosis of breast metastasis from gastric carcinoma is generally poor. We report a case of breast metastasis of gastric signet ring cell carcinoma in a 38-year-old woman. She started chemotherapy with ramucirumab, paclitaxel, and irinotecan. Three months later, a combined 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography showed a complete response. This is the first reported case of breast metastasis from gastric signet ring cell carcinoma with a complete response.

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Section: Discussionmentioning

confidence: 99%

Breast Metastasis of Gastric Signet Ring Cell Carcinoma: A Case Report and Literature Review

et al. 2021

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Intramammary Metastases from Extramammary Malignancies: An Update

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Ortiz-Perez

Dhamne

et al. 2023

Curr Breast Cancer Rep

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Gastrointestinal metastatic signet ring cell breast cancer in young females: a case report

Zhang

et al. 2022

Gland Surg

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Background: Signet ring cell carcinoma (SRCC) is characterized by strong invasiveness and rapid progression. It occurs mostly in young and middle-aged patients, and early patients may have no clinical symptoms. Gastric SRCC with breast cancer metastasis is relatively rare. It often presents challenges for clinicians and pathologists and may lead to an absolutely different therapeutic strategy.Case Description: In this paper, we report on a 37-year-old woman who was admitted to the hospital with a left breast mass discovered 5 days earlier, the mass was occasionally painful, and there was no skin swelling, skin depression, or other abnormalities. The initial diagnosis considered her to have a left breast tumor. The patient was previously healthy with no family history of tumor. Considering the possibility of malignant lesions, she underwent resection of the left breast tumor and surrounding tissue. Postoperative pathological findings suggested SRCC (left breast mass). Although the patient had no history of gastrointestinal tumors, considering that SRCC can also appear in the gastrointestinal tract and other organs.We performed gastroscopy on the patient, showed an ulcerative mass in the greater curvature of the gastric body, with irregular nodular uplift of the surrounding mucosa. The excised breast lesions were analyzed by immunohistochemistry, and the pathological result showed SRCC (left breast tumor). Combined with the results of immunohistochemistry, it was consistent with gastrointestinal metastasis. Through our multifaceted differential diagnosis, the final diagnosis of the patient was clear, which not only bought time for the patient's subsequent treatment, but also avoided misdiagnosis and blind treatment due to the particularity and rarity of the case.Conclusions: Gastric cancer should be considered when breast tumors show SRCC without in situ lesion.Signet ring cell gastric cancer (occult) should be excluded even if the patient has no family history of gastric cancer. It is important to distinguish metastatic cancer from primary breast cancer to avoid misdiagnosis and blind treatment due to the particularity of the case, at which point an early recognition can be made and an optimal treatment plan can be chosen.

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Metastatic gastric carcinoma to the breast: Aï¿½caseï¿½report and review of the Chinese literature

Cited by 4 publications

References 9 publications

Breast Metastasis of Gastric Signet Ring Cell Carcinoma: A Case Report and Literature Review

Breast Metastasis of Gastric Signet Ring Cell Carcinoma: A Case Report and Literature Review

Intramammary Metastases from Extramammary Malignancies: An Update

Gastrointestinal metastatic signet ring cell breast cancer in young females: a case report

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