Clinical-Pathological Conference Series from the Medical University of Graz

Fabian, Elisabeth; Schiller, Dietmar; Toplak, Hermann; Brunner‐Krainz, Michaela; Fazekas, Franz; Schoefl, Rainer; Krejs, Guenter J.

doi:10.1007/s00508-017-1291-y

Cited by 4 publications

(1 citation statement)

References 59 publications

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“…It appears that the main cause of pseudoachalasia is an adenocarcinoma at the GEJ; however, similar effects have been also reported with multiple other cancers such as lung, pancreatic, breast, and cervical cancers, pleural mesothelioma, and multiple myeloma [ 14 - 21 ]. Nonmalignant causes of pseudoachalasia include, but are not limited to, amyloidosis, sarcoidosis, thoracic aortic aneurysm, systemic mastocytosis, Chagas disease, neurofibromatosis, histiocytosis-x, and Fabry disease with the accumulation of lysosomal Gb3 [ 6 , 22 - 29 ]. Anti-reflux surgery can also lead to pseudoachalasia due to misdiagnosed idiopathic achalasia with dysphagia symptoms postoperatively, underlying gastroesophageal reflux leading to achalasia, and an excessively tight fundic wrap or scar tissue development postoperatively.…”

Section: Discussionmentioning

confidence: 99%

Delayed Presentation of Malignancy-Associated Pseudoachalasia of the Gastric Cardia

Miranda,

Azad,

Moyer

et al. 2024

Cureus

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Pseudoachalasia is a condition in which symptoms, manometry, and imaging findings highly resemble primary achalasia but has a secondary etiology. The majority of patients with pseudoachalasia have the condition as the result of a malignancy, most often at the gastroesophageal junction. There may be issues with timely identification of this malignancy as symptoms are often obscure with diagnostic testing yielding nonspecific results. We describe a case of a 65-year-old diabetic female smoker with a four-month history of intractable vomiting, abdominal pain, and weight loss who was belatedly found to have an adenocarcinoma at the gastric cardia necessitating a total gastrectomy and chemotherapy administration. The case educates clinicians on the clinical alarm symptoms related to malignant pseudoachalasia and stresses the paramount importance of performing a timely esophagogastroduodenoscopy in all cases of achalasia, even with seemingly normal imaging, to rule out pseudoachalasia related to malignancy.

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Section: Discussionmentioning

confidence: 99%

Delayed Presentation of Malignancy-Associated Pseudoachalasia of the Gastric Cardia

Miranda,

Azad,

Moyer

et al. 2024

Cureus

View full text Add to dashboard Cite

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Prevalence of GLA gene mutations and polymorphisms in patients with multiple sclerosis: A cross-sectional study

Russo

Cocozza

Riccio

et al. 2020

Journal of the Neurological Sciences

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Severe strongyloidiasis: a systematic review and meta-analysis of 339 cases

Rojas

Montoya

Villanueva-Lozano

et al. 2023

Transactions of the Royal Society of Tropical Medicine and Hygiene

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Strongyloidiasis is a parasitosis representing a significant public health problem in tropical countries. It is often asymptomatic in immunocompetent individuals but its mortality rate increases to approximately 87% in severe forms of the disease. We conducted a systematic review, including case reports and case series, of Strongyloides hyperinfection and dissemination from 1998 to 2020 searching PubMed, EBSCO and SciELO. Cases that met the inclusion criteria of the Preferred Reported Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist were analysed. Statistical analysis was performed using Fisher’s exact test and Student's t-test and a Bonferroni correction for all the significant values. A total of 339 cases were included in this review. The mortality rate was 44.83%. The presence of infectious complications, septic shock and a lack of treatment were risk factors for a fatal outcome. Eosinophilia and ivermectin treatment were associated with an improved outcome.

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Clinical-Pathological Conference Series from the Medical University of Graz

Cited by 4 publications

References 59 publications

Delayed Presentation of Malignancy-Associated Pseudoachalasia of the Gastric Cardia

Delayed Presentation of Malignancy-Associated Pseudoachalasia of the Gastric Cardia

Prevalence of GLA gene mutations and polymorphisms in patients with multiple sclerosis: A cross-sectional study

Severe strongyloidiasis: a systematic review and meta-analysis of 339 cases

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