Clinical patch test data evaluated by multivariate analysis

Christophersen, J; Menné, Torkil; Tanghøj, Per; Andersen, Klaus Ejner; Brandrup, Flemming; Kaaber, K; Osmundsen, P. E.; Thestrup‐Pedersen, Kristian; Veien, Niels K.

doi:10.1111/j.1600-0536.1989.tb04746.x

Cited by 106 publications

(43 citation statements)

References 5 publications

(4 reference statements)

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“…4 Sarıcaoğlu et al detected reaction with single substance in 61% of 72 patients. 10 In our study, at least one allergen positivity was detected in 72,2% of seventy two positive allergic reactions.…”

Section: Discussionmentioning

confidence: 86%

“…4 Sarıcaoğlu et al detected positive reaction in ratios of 28% nickel sulfate, 15,2% potassium dichromate and 11,8% benzokain in their tests of 24 substances. 10 Hogan et al observed allergic reaction in the ratios of 17,4% nickel sulfate, 8,7% ethylendiamine and 7,4% formaldehyde in their tests on 20 substances. 12 Kotoğyan et al detected 9,4% nickel sulfate out of 53 allergic reactions and this was followed by potassium dichromate 30,4% and PPD 19%.…”

Section: Discussionmentioning

confidence: 99%

“…1,10,19 When the occupations of dermatitis patients were questioned in our study, the first place was taken by the housewives.…”

Section: Discussionmentioning

confidence: 99%

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•Evaluation of patch test results in patients with contact dermatitis

Yeşilova¹

2011

Dicle Med J

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ÖZETAmaç: Yama testi, allerjik kontakt dermatit tanısını doğ-rulayan ve kontakt allerjinin sebebini bulmamızı sağlayan en önemli tanısal yöntemdir Retrospektif olarak yapılan çalışmamızda, bölgemizde kontakt dermatitli hastaların yama testi sonuçlarının değerlendirilmesi amaçlanmıştır. Gereç ve yöntem:Kontakt dermatit tanısı alan hastaların 84'ü (%56) kadın, 66'sı (%44) erkek, toplam 150 hastaya Avrupa standart test serisi ile yama testi yapıldı. Test, Uluslararası Kontakt Dermatitis Araştırma Grubu tarafın-dan standardize edilmiştir. Bulgular:Lezyonların en sık ellerde (%36) yerleştiği gö-rüldü. 31''i kadın (%58,4), 21'i erkek (%41,6) olmak üzere toplam 72 hastada (%48) bir veya birden fazla maddeye karşı pozitif allerjik reaksiyon elde edildi. En sık reaksiyon saptanan allerjenler ise nikel sülfat (%13,3), potasyum dikromat (%11,3) ve kobalt klorid (%8,6) idi.Sonuç: Kontak dermatite nikel hassasiyetinin daha fazla olduğu bulundu. Sağlıklı kontrollerle karşılaştırıldığında kontakt dermatiti hastalarda deri yama testini daha sık görülmüştür. Anahtar kelimeler: Kontakt dermatit, yama testi, nikel sülfat ABSTRACTObjectives: Patch test is the most reliable method to diagnose allergic contact dermatitis and to find out the responsible contact allergen. The aim of this retrospective study was to evaluate the patch test results of patients with contact dermatitis in our region. Materials and methods:One Hundred fifty patients (84 female and 66 male) with contact dermatitis were patch tested with European standard test series. The testing has been standardized by the international Contact Dermatitis Research Group (ICDRG).Results: A majority of the lesions (36%) were localized on the hands. In 31 female (58,4%) and 21 male (4,6%) patients (a total of 72 patients) there were positive allergic reactions to at least one chemical. Nickel sulphate (13,3%), potassium dichromate (11,3%) and cobalt chloride (8,6%) were the most often allergens reacted. Conclusion:Nickel sensitivity is more common. Comparing with healthy controls contact sensitization may be more prevalent in patients with contact dermatitis.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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•Evaluation of patch test results in patients with contact dermatitis

Yeşilova¹

2011

Dicle Med J

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“…In not a single study routinely testing the fragrance mix has the clinical picture of patients with positive reactions to the mix been investigated and compared with contact dermatitis patients not sensitized to fragrances, although it has been shown that patients with hand dermatitis and leg ulcers/stasis dermatitis have an odds ratio of2.6 of being sensitized to the fragrance mix compared to patients with no hand dermatitis or stasis dermatitis (76). It can be expected, however, that the neck, the skin behind the ear and the axillae (77) are often implicated, being exposed to products with high concentrations of fragrances (perfume, deodorant).…”

Section: Clinical Picture Of Allergic Contact Dermatitis From Fragrancesmentioning

confidence: 99%

Adverse reactions to fragrances

Groot¹,

1997

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Con/act Dermatilis. /997. 36, This article reviews side-effects of fragrance materials present in cosmetics with emphasis on clinical aspects: epidemiology, types of adverse reactions, clinical picture, diagnostic procedures, and the sensitizers. Considering the ubiquitous occurrence of fragrance materials, the risk of sideeffects is small. In absolute numbers, however, fragrance allergy is common, affecting approximately 1% of the general population. Although a detailed profile of patients sensitized to fragrances needs to be elucidated, common features of contact allergy are: axillary dermatitis, dermatitis of the face (including the eyelids) and neck, well-circumscribed patches in areas of "dabbing-on" perfumes (wrists, behind the ears) and (aggravation of) hand eczema. Depending on the degree of sensitivity, the severity of dermatitis may range from mild to severe with dissemination and even erythroderma. Airborne or "connubial" contact dermatitis should always be suspected. Other less frequent adverse reactions to fragrances are photocontact dermatitis, immediate contact reactions and pigmentary changes. The fragrance mix, although very useful for the detection of sensitive patients, both causes false-positive and false-negative reactions, and detects only 70% of perfumeallergic patients. Therefore, future research should be directed at increasing the sensitivity and the specificity of the mix. Relevance is said to be established in 50-65% of positive reactions, but accurate criteria are needed. Suggestions are made for large-scale investigation of several fragrances on the basis of literature data and frequency of use in cosmetics. The literature on adverse reactions to balsam of Peru (an indicator for fragrance sensitivity), essential oils (which currently appear to be used more in aromatherapy than in perfumery) and on fragrances used as flavours and spices in foods and beverages is not discussed in detail, but pertinent side-effects data are tabulated and relevant literature is provided. Key words: perfume; fragrance; adverse reactions; fragrance mix; balsam of Peru; essential oils; allergic contact dermatitis; photosensitivity; immediate contact reactions; pigmented cosmetic dermatitis; occupational contact dermatitis. © Munksgaard, 1997. Accepted for publication 15 October 1996This article reviews side-effects of fragrance materials present in cosmetic products with emphasis on clinical aspects: epidemiology, types of adverse reactions, clinical picture, diagnostic procedures, and the sensitizers. Adverse reactions to balsam of Peru, a marker for fragrance sensitivity (!), which detects approximately 50% of patients allergic to fragrance materials (2), and to fragrances from non-cosmetic sources (e.g., flavours in food) are not discussed in detail. Essential oils seem to be more often used nowadays for medicinal (notably aromatherapy (3)) than for cosmetic purposes. Only the adverse reactions from their presence in cosmetic fragrances are included. However, because of their close relationship to fragr...

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“…As an additional, confounding factor on top of such a presumptive 'baseline age effect', the topical treatment of age-related diseases -namely varicose ulcers and stasis dermatitis [5,6] -strongly influences the spectrum of allergens found in the elderly. As yet, this aspect has not been addressed in detail, and the influence of varicose ulcer/stasis dermatitis has previously been accounted for only regarding a limited set of 8 allergens in a multifactorial analysis [7]. Therefore, a retrospective analysis was performed with current data of the Information Network of Departments of Dermatology (Informationsverbund Dermatologischer Kliniken, IVDK), which, for the first time, undertook to explicitly address the confounding influence of stasis dermatitis on the spectrum of contact sensitisation against allergens included in the German standard patch test series in elderly patients.…”

mentioning

confidence: 99%

The Spectrum of Contact Allergy in Elderly Patients with and without Lower Leg Dermatitis

et al. 2002

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Background: There is a strong influence of lower leg dermatitis on the spectrum of allergic contact sensitivity in elderly patients. Objective: To quantitatively assess the impact of this factor which confounds the age-related pattern of allergic contact sensitivity. Methods: Stratified analysis of allergic contact sensitivity data collected between 1996 and 1999 in the 32 centres of the Information Network of Departments of Dermatology (three age groups: ≤60, 61–75, ≧76 years), both as crude and as directly standardised (for sex and leg dermatitis) proportions. Results: Among the 36,070 patients tested with the German standard series, allergic contact sensitivity to neomycin, lanolin, cetostearylic alcohols, colophony, fragrance mix and balsam of Peru, among others, was (much) more common in the elderly, with proportions more or less affected by standardisation. Conclusion: The comparison of crude and standardised proportions provides evidence that allergic contact sensitivity to several allergens strongly depends not only on age itself, but on age-related and thus confounding co-morbidity.

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Clinical patch test data evaluated by multivariate analysis

Cited by 106 publications

References 5 publications

•Evaluation of patch test results in patients with contact dermatitis

•Evaluation of patch test results in patients with contact dermatitis

Adverse reactions to fragrances

The Spectrum of Contact Allergy in Elderly Patients with and without Lower Leg Dermatitis

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