Clinical papers

Leengoed, L A van; Vos, J. H.; Gruys, E.; Rondhuis, P. R.; Brand, A.

doi:10.1080/01652176.1983.9693887

Cited by 27 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is interesting to note that, in samples from aborted pig fetuses collected in Beijing, only PPV6 was detected. Targeted studies are needed to investigate the role of this virus in the sows with reproductive failure [ 2 ]. However, the number of clinical samples detected in this study was limited and more extensive epidemiologic studies are needed to elucidate the precise role of PPV6 as a causal agent for reproductive failure.…”

Section: Resultsmentioning

confidence: 99%

“…Porcine parvoviruses (PPV) are important pathogens that cause reproductive failure in swine, resulting in enormous losses in the pig industry worldwide [ 1 ]. Epidemiological studies and diagnostic surveys have demonstrated that PPV was the major causative agent responsible for embryonic and fetal death in swine [ 2 ]. Parvoviruses are classified into two subfamilies based on their host range: the Parvovirinae , which infect vertebrates, and the Densovirinae , which mainly infect insects and other arthropods.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Identification and genomic characterization of a novel porcine parvovirus (PPV6) in china

Qiao

Han

et al. 2014

Virol J

View full text Add to dashboard Cite

BackgroundParvoviruses are classified into two subfamilies based on their host range: the Parvovirinae, which infect vertebrates, and the Densovirinae, which mainly infect insects and other arthropods. In recent years, a number of novel parvoviruses belonging to the subfamily Parvovirinae have been identified from various animal species and humans, including human parvovirus 4 (PARV4), porcine hokovirus, ovine partetravirus, porcine parvovirus 4 (PPV4), and porcine parvovirus 5 (PPV5).MethodsUsing sequence-independent single primer amplification (SISPA), a novel parvovirus within the subfamily Parvovirinae that was distinct from any known parvoviruses was identified and five full-length genome sequences were determined and analyzed.ResultsA novel porcine parvovirus, provisionally named PPV6, was initially identified from aborted pig fetuses in China. Retrospective studies revealed the prevalence of PPV6 in aborted pig fetuses and piglets(50% and 75%, respectively) was apparently higher than that in finishing pigs and sows (15.6% and 3.8% respectively). Furthermore, the prevalence of PPV6 in finishing pig was similar in affected and unaffected farms (i.e. 16.7% vs. 13.6%-21.7%). This finding indicates that animal age, perhaps due to increased innate immune resistance, strongly influences the level of PPV6 viremia. Complete genome sequencing and multiple alignments have shown that the nearly full-length genome sequences were approximately 6,100 nucleotides in length and shared 20.5%–42.6% DNA sequence identity with other members of the Parvovirinae subfamily. Phylogenetic analysis showed that PPV6 was significantly distinct from other known parvoviruses and was most closely related to PPV4.ConclusionOur findings and review of published parvovirus sequences suggested that a novel porcine parvovirus is currently circulating in China and might be classified into the novel genus Copiparvovirus within the subfamily Parvovirinae. However, the clinical manifestations of PPV6 are still unknown in that the prevalence of PPV6 was similar between healthy pigs and sick pigs in a retrospective epidemiological study. The identification of PPV6 within the subfamily Parvovirinae provides further insight into the viral and genetic diversity of parvoviruses.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification and genomic characterization of a novel porcine parvovirus (PPV6) in china

Qiao

Han

et al. 2014

Virol J

View full text Add to dashboard Cite

show abstract

“…The parvoviruses are small, non-enveloped, single-stranded DNA viruses. PPV is a major cause of reproductive failure in sows and is a significant cofactor in porcine postweaning multisystemic wasting syndrome [1][2][3]. PPV was first isolated from pigs with fever in 1965 [4].…”

Section: Introductionmentioning

confidence: 99%

“…PPV was first isolated from pigs with fever in 1965 [4]. It is commonly found in diseased pigs and is the cause of significant economic loss for the swine industry today [1,[5][6][7][8][9]. Currently, vaccination is the primary measure for prevention of PPV.…”

Section: Introductionmentioning

confidence: 99%

Antiviral effect of lithium chloride on infection of cells by porcine parvovirus

et al. 2015

View full text Add to dashboard Cite

Porcine parvovirus (PPV) causes reproductive failure in pigs, which leads to economic losses to the industry. As reported previously, LiCl efficiently impairs the replication of a variety of viruses, including the coronavirus infectious bronchitis virus (IBV), transmissible gastroenteritis virus (TGEV), and pseudorabies herpesvirus. We demonstrate for the first time that inhibition of PPV replication in swine testis (ST) cells by LiCl is dose-dependent, and that the antiviral effect of LiCl occurred in the early phase of PPV replication. These results indicate that LiCl might be an effective anti-PPV drug to control PPV disease. Further studies are required to explore the mechanism of the antiviral effect of LiCl on PPV infection in vivo.

show abstract

“…Members of the Parvovirinae subfamily are among the most dangerous and economically most harmful viruses of domesticated and farm animals (e.g., canine parvovirus (CPV) [16], goose parvovirus (GPV) [17] porcine parvovirus (PPV) [18] and are also able to cause diseases in humans (B19) [19] and human bocavirus [20,21]. PPV is responsible for syndrome of reproductive failure in swine, included infertility, early embryonic death, mummified fetuses and stillbirths [22].…”

Section: Introductionmentioning

confidence: 99%

CpG Distribution and Methylation Pattern in Porcine Parvovirus

et al. 2013

View full text Add to dashboard Cite

Based on GC content and the observed/expected CpG ratio (oCpGr), we found three major groups among the members of subfamily Parvovirinae: Group I parvoviruses with low GC content and low oCpGr values, Group II with low GC content and high oCpGr values and Group III with high GC content and high oCpGr values. Porcine parvovirus belongs to Group I and it features an ascendant CpG distribution by position in its coding regions similarly to the majority of the parvoviruses. The entire PPV genome remains hypomethylated during the viral lifecycle independently from the tissue of origin. In vitro CpG methylation of the genome has a modest inhibitory effect on PPV replication. The in vitro hypermethylation disappears from the replicating PPV genome suggesting that beside the maintenance DNMT1 the de novo DNMT3a and DNMT3b DNA methyltransferases can’t methylate replicating PPV DNA effectively either, despite that the PPV infection does not seem to influence the expression, translation or localization of the DNA methylases. SNP analysis revealed high mutability of the CpG sites in the PPV genome, while introduction of 29 extra CpG sites into the genome has no significant biological effects on PPV replication in vitro. These experiments raise the possibility that beyond natural selection mutational pressure may also significantly contribute to the low level of the CpG sites in the PPV genome.

show abstract

Clinical papers

Cited by 27 publications

References 21 publications

Identification and genomic characterization of a novel porcine parvovirus (PPV6) in china

Identification and genomic characterization of a novel porcine parvovirus (PPV6) in china

Antiviral effect of lithium chloride on infection of cells by porcine parvovirus

CpG Distribution and Methylation Pattern in Porcine Parvovirus

Contact Info

Product

Resources

About