2004
DOI: 10.1007/s00280-004-0880-4 View full text |Buy / Rent full text
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Abstract: Adjuvant therapy has been tested widely in the treatment of cancers of the stomach, pancreas, and large bowel. In the USA, the use of postoperative chemoradiation in stomach cancer is considered a standard of care after the publication of the Intergroup Study 0116 in September 2001. This study demonstrated significant benefit in overall and disease-free survival for patients receiving postoperative treatment with fluorouracil (5-FU)/leucovorin chemotherapy and radiation after gastric resection. Adjuvant chemot… Show more

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“…However, even in patients presenting with early stage disease, about 60% eventually have local relapse or distant metastases after curative resection [4]. Various adjunctive therapies (such as chemotherapy, radiation therapy [RT], or immunotherapy) have been studied in an attempt to improve survival in patients with resectable gastric cancer [5][6][7]. The role of adjuvant therapies has only recently been clariWed, following the results of three well designed randomized studies with more than 500 patients included in each, all showing a survival beneWt [8][9][10].…”
Section: Introductionmentioning
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“…However, even in patients presenting with early stage disease, about 60% eventually have local relapse or distant metastases after curative resection [4]. Various adjunctive therapies (such as chemotherapy, radiation therapy [RT], or immunotherapy) have been studied in an attempt to improve survival in patients with resectable gastric cancer [5][6][7]. The role of adjuvant therapies has only recently been clariWed, following the results of three well designed randomized studies with more than 500 patients included in each, all showing a survival beneWt [8][9][10].…”
Section: Introductionmentioning
“…The cell suspension (5 million cells/mouse) was implanted subcutaneously in NSG mice. Once the tumors reached 100-200 mm 3 , the animals were randomized within the respective cell line and treated orally at 50 mg/kg/day. PNB-028 was dissolved in 20% DMSO+80% PEG-300 and administered by oral gavage.…”
Section: Methodsmentioning
“…Cancer cells were implanted subcutaneously in NSG mice and when tumor volume reached 100-200 mm 3 , the animals were randomized and treated with vehicle or 50 mg/kg/day PNB-028 orally. Tumor volume was measured thrice weekly and animals were sacrificed when tumors reached >1,500 mm 3 .…”
Section: Pnb-028 Inhibits Colon and Pancreatic Cancer Xenografts In Nmentioning
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“…Surgery is the main treatment for early-stage disease, but most of these patients have advanced cancer or have local or distant recurrence by the time of diagnosis (MacDonald, 2004). Therefore, neoadjuvant chemotherapy followed by surgery has become a main treatment method for prolonging the survival of these patients.…”
Section: Introductionmentioning