2014
DOI: 10.4238/2014.october.27.13
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Abstract: ABSTRACT. We conducted a cohort study to investigate the role of 2 single-nucleotide polymorphisms of the excision repair crosscomplimentary group 1 (ERCC1) gene polymorphism in response to chemotherapy and clinical outcomes of gastric cancer. A total of 231 patients with newly diagnosed and histopathologically confirmed primary gastric cancer participated in the study. ERCC1 rs11615 and rs3212986 were genotyped. Individuals with the ERCC1 rs11615 TT genotype and the T allele showed a significant poorer respon… Show more

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Cited by 9 publications
(11 citation statements)
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“…Several previous studies have reported an association between ERCC1 gene polymorphisms and prognosis in gastric cancer Liu et al, 2014;Ma et al, 2015;Xue et al, 2015;Yu et al, 2015;Zhou et al, 2015). Xue et al (2015) reported that ERCC1 rs11615 and rs3212986 polymorphisms affect the clinical outcome of patients with gastric cancer.…”
Section: Discussionmentioning
confidence: 98%
“…Several previous studies have reported an association between ERCC1 gene polymorphisms and prognosis in gastric cancer Liu et al, 2014;Ma et al, 2015;Xue et al, 2015;Yu et al, 2015;Zhou et al, 2015). Xue et al (2015) reported that ERCC1 rs11615 and rs3212986 polymorphisms affect the clinical outcome of patients with gastric cancer.…”
Section: Discussionmentioning
confidence: 98%
“…Several studies have reported the role of ERCC1 polymorphisms in the treatment outcome of patients with gastric cancer, but the results are controversial (Chen et al, 2014;Li et al, 2014b;Liu et al, 2014;Lu et al, 2014;Zhou et al, 2015). Chen et al (2014) reported that the ERCC1 rs11615 TT genotype had increased risk of death from gastric cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Chen et al (2014) reported that the ERCC1 rs11615 TT genotype had increased risk of death from gastric cancer. Li et al (2014) reported that ERCC1 rs11615 polymorphisms were associated with risk of death when compared with the wide-type genotype. Liu et al (2014) reported that carriers of the ERCC1 rs11615 TT genotype had a higher increased risk of OS when compared with CC genotype.…”
Section: Discussionmentioning
confidence: 99%
“…Many epidemiologic studies have reported that ERCC1 polymorphisms may influence the outcome of cisplatin treatment in gastric cancer, non-small cell lung cancer (NSCLC), ovarian cancer, and esophageal squamous cell carcinoma (Qi et al, 2013;Chen et al, 2014;Gao et al, 2014;Liu et al, 2014). Liu et al (2014) conducted a cohort study to investigate the role of ERCC1 gene polymorphism in response to chemotherapy and clinical outcome in gastric cancer, and did not find the ERCC1 rs3212986 polymorphism to be associated with OS in gastric cancer.…”
Section: Discussionmentioning
confidence: 99%
“…Liu et al (2014) conducted a cohort study to investigate the role of ERCC1 gene polymorphism in response to chemotherapy and clinical outcome in gastric cancer, and did not find the ERCC1 rs3212986 polymorphism to be associated with OS in gastric cancer. Gao et al (2014) also conducted a cohort study to investigate the role of three SNPs of ERCC1 in the clinical outcome of NSCLC, and found that the TT genotype of ERCC1 rs11615 and the AA genotype of rs3212986 polymorphisms were associated with increased risk of death from NSCLC.…”
Section: Discussionmentioning
confidence: 99%