The precise circuit of cavotricuspid isthmus (CTI)-dependent atrial flutters (AFLs) has been well characterized, but the recent arrival of ultrahigh-resolution mapping systems has further improved our understanding of this "old" arrhythmia. CTI-dependent AFL may be the arrhythmia for which the electrocardiograph (ECG) correlation with the mechanism may be the highest. Once the diagnosis is made (predominantly based upon the surface ECG), the therapeutic options are precisely defined, with radiofrequency catheter ablation representing an efficient strategy with a high success rate and few complications. This article will focus on the clinical perspectives for CTI-dependent AFL.