Clinical Outcomes of Patients with Histologic Variants of Urothelial Cancer Treated with Trimodality Bladder-sparing Therapy

Krasnow, Ross; Drumm, Michael; Roberts, Hannah; Niemierko, Andrzej; Wu, Chin‐Lee; Wu, Shulin; Zhang, Jing; Heney, Niall M.; Wszolek, Matthew F.; Blute, Michael L.; Feldman, Adam S.; Lee, Richard J.; Zietman, Anthony L.; Shipley, William U.; Efstathiou, Jason A.

doi:10.1016/j.eururo.2016.12.002

Cited by 71 publications

(44 citation statements)

References 25 publications

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“…In their multivariate analysis including several clinical and pathologic variables, the authors confirmed the independent prognostic roles of age, stage, hydronephrosis and CR after induction CRT in the total cohort (12). These are in line with several reports from the same and other groups including Radiation Therapy Oncology Group (RTOG) protocols (8802, 8903, 9506, 9706, 9906, 0233) and nomograms which were developed to predict outcomes in patients undergoing TMT (15,16).…”

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confidence: 71%

“…No significant differences were found between the subgroup of 66 (22%) patients with VUC and the rest PUC population. In addition, there were no differences in the rate of CR or salvage cystectomy (12). …”

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confidence: 99%

“…The study entitled “ Clinical outcomes of patients with histologic variants of urothelial cancer treated with trimodality bladder - sparing therapy ” by Krasnow et al , recently published in European Urology Journal , addressed, for the first time, the role of TMT in outcomes of VUC patients (12). The authors of this retrospective study investigated the 5-yr and 10-yr disease-specific and OS of 303 patients with MIBC treated with TMT.…”

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confidence: 99%

“…In the study of Krasnow et al (12), less than half of VUC patients had available tissue for pathology re-review, thus the effect of VUC extent on the studied outcomes is unknown. In their multivariate analysis including several clinical and pathologic variables, the authors confirmed the independent prognostic roles of age, stage, hydronephrosis and CR after induction CRT in the total cohort (12).…”

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confidence: 99%

“…Optimal candidates for TMT are not just patients with co-morbidities less fit for radical surgery. Based upon the available data, including the large retrospective series published by Krasnow et al (12), the presence (or absence) of VUC should not influence one’s decision on a RC with/without neoadjuvant chemotherapy vs. TMT approach. Increasing genomic data as well as the potential use of targeted therapy or immunotherapy may be of use in the future.…”

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confidence: 99%

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Contemporary use trends and survival outcomes in patients undergoing radical cystectomy or bladder‐preservation therapy for muscle‐invasive bladder cancer

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miRNA profiling in the hippocampus of attention‐deficit/hyperactivity disorder rats

Tian

Zhang

et al. 2018

J of Cellular Biochemistry

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Attention-deficit/hyperactivity disorder (ADHD) is characterized by attention deficit, hyperactivity, impulsivity, and learning and memory impairment.Although the pathogenesis of learning and memory impairment is still unknown, some studies have suggested an association with hippocampus dysfunction. We aimed to explore the role of miRNAs in the learning and memory impairments observed in ADHD. Differentially expressed hippocampal micro-ribonucleic acids (miRNAs) in spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats (WKYs) were detected on an Illumina HiSeq. 2000 genome analyzer. A total of 25 differentially expressed miRNAs (fold-change ≥ 2 and P-value < 0.05) were identified. The target genes of these differentially expressed miRNAs were predicted using online tools (TargetScan and miRDB). Gene ontology and pathway analysis of the predicted target genes were carried out to assess their putative biological functions. Meanwhile, quantitative realtime PCR was used to validate the HiSeq results, revealing that three miRNAs (miR-1-b, miR-741-3p, and miR-206-3p) were upregulated and four (miR-182, miR-471-5p, miR-183-5p, and miR-211-5p) were downregulated in the SHR group compared with the WKY group. In addition, we confirmed that Dyrk1a is regulated by miR-211-5p. These results help us understand the contribution of miRNAs in the hippocampus to ADHD and provide new insights into the pathogenesis of this condition. K E Y W O R D S attention-deficit/hyperactivity disorder (ADHD), high-throughput sequencing, microRNA (miRNAs), spontaneously hypertensive rat (SHR), Wistar-Kyoto rat (WKY) J Cell Biochem. 2019;120:3621-3629.wileyonlinelibrary.com/journal/jcb

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Clinical Outcomes of Patients with Histologic Variants of Urothelial Cancer Treated with Trimodality Bladder-sparing Therapy

Cited by 71 publications

References 25 publications

Trimodality therapy in variant urothelial carcinoma: choose wisely

Trimodality therapy in variant urothelial carcinoma: choose wisely

Contemporary use trends and survival outcomes in patients undergoing radical cystectomy or bladder‐preservation therapy for muscle‐invasive bladder cancer

miRNA profiling in the hippocampus of attention‐deficit/hyperactivity disorder rats

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