Clinical outcomes of conjugated linoleic acid supplementation in the overweight and the obese: a study protocol

Łochocka, Klaudia; Glapa, Aleksandra; Nowak, Jan; Duś-Żuchowska, Monika; Grabańska, Katarzyna; Bogdański, Paweł; Fidler, Ewa; Mądry, Edyta; Walkowiak, Jarosław

doi:10.20883/medical.e86

Cited by 3 publications

(3 citation statements)

References 16 publications

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“…The subjects' randomization codes were concealed until the time of the final analysis. Consumption of 75% of the provided supplement every week of the study was the criterion for completion of the study [22]. The level of significance was set at p<0.05.…”

Section: Discussionmentioning

confidence: 99%

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Conjugated linoleic acid does not affect digestion and absorption of fat and starch—a randomized, double-blinded, placebo-controlled parallel study

et al. 2017

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Section: Discussionmentioning

confidence: 99%

“…In the TEE assessment a dose of 50 mg of 13 C bicarbonate was administrated orally after dissolution in about 125-150 ml of warm fruit tea. Breath samples were acquired from each subject over a total timespan of 3 h [22].…”

Section: B-bt Proceduresmentioning

confidence: 99%

Conjugated linoleic acid does not affect digestion and absorption of fat and starch—a randomized, double-blinded, placebo-controlled parallel study

et al. 2017

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“…As described previously [ 9 , 24 , 25 , 26 , 27 ], the study was designed as a parallel, double-blind, randomised controlled trial, registered with the German Clinical Trials Register database (ID: DRKS00010462, date of registration: 4 May 2016) [ 28 ]. The study protocol was approved by the Poznan University of Medical Sciences Ethics Committee (protocol code: 606/12, date of approval: 14 June 2012; protocol code: 453/13, date of approval: 9 May 2013; protocol code: 358/14, date of approval: 3 April 2014; protocol code: 398/15, date of approval: 9 April 2015).…”

Section: Methodsmentioning

confidence: 99%

The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial

Jamka,

Czochralska-Duszyńska,

Mądry

et al. 2023

Medicina

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Background and Objectives: Conjugated linoleic acid (CLA) can improve bone health in animals, yet the effects on humans have not been consistent. Therefore, this parallel randomised controlled trial aimed to assess the effect of CLA supplementation on bone mineral density (BMD) and content (BMC) in overweight or obese women. Materials and Methods: The study population included 74 women who were divided into the CLA (n = 37) and control (n = 37) groups. The CLA group received six capsules per day containing approximately 3 g of cis-9, trans-11 and trans-10, cis-12 CLA isomers in a 50:50 ratio. The control group received the same number of placebo capsules that contained sunflower oil. BMC and BMD at total body, lumbar spine (L1–L4), and femoral neck were measured before and after a three-month intervention. Results: The comparison of BMC and BMD for the total body, lumbar spine (L1–L4), and femoral neck before and after the intervention showed no differences between the groups. However, a within-group analysis demonstrated a significant increase in BMC (p = 0.0100) and BMD (p = 0.0397) at lumbar spine (L1–L4) in the CLA group. Nevertheless, there were no significant differences between the CLA and placebo groups in changes in all analysed densitometric parameters. Conclusions: Altogether, three-month CLA supplementation in overweight and obese women did not improve bone health, although the short intervention period could have limited our findings, long-term intervention studies are needed. The study protocol was registered in the German Clinical Trials Register database (ID: DRKS00010462, date of registration: 4 May 2016).

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Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial

Mądry

Chudzicka-Strugała

Grabańska-Martyńska

et al. 2016

Acta Sci Pol Technol Aliment

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Background. Conjugated linoleic acid (CLA) reduces body weight (BW), body fat mass (BFM), and increases or maintains lean body mass in animals. However, the results concerning the eff ect of CLA on weight reduction in humans are contradictory. The present study aimed to evaluate the eff ect of CLA supplementation on the BW and anthropometric parameters (waist and hip circumferences) in overweight and obese adult women. Material and methods. A total of 74 subjects (BMI: 28-42 kg/m

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Clinical outcomes of conjugated linoleic acid supplementation in the overweight and the obese: a study protocol

Cited by 3 publications

References 16 publications

Conjugated linoleic acid does not affect digestion and absorption of fat and starch—a randomized, double-blinded, placebo-controlled parallel study

Conjugated linoleic acid does not affect digestion and absorption of fat and starch—a randomized, double-blinded, placebo-controlled parallel study

The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial

Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial

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