Conjugated linoleic acid does not affect digestion and absorption of fat and starch—a randomized, double-blinded, placebo-controlled parallel study

Walkowiak, Jarosław; Malikowska, Klaudia; Glapa, Aleksandra; Bogdański, Paweł; Fidler-Witoń, Ewa; Szulińska, Monika; Chudzicka-Strugała, Izabela; Miśkiewicz-Chotnicka, Anna; Mądry, Edyta; Lisowska, Aleksandra

doi:10.1088/1752-7163/aa872d

Cited by 4 publications

(4 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…43 Differently from our results, CLA didn't affect the fat digestion and absorption in humans. 44 This may be due to the different regulatory effects of CLA on fat absorption in different species. Moreover, the lipoprotein lipase (LPL) inhibitor poloxamer 407 injection and lard oil gavage experiments were conducted to directly evaluate the intestinal fat absorption of mice (Fig.…”

Section: Discussionmentioning

confidence: 99%

Conjugated linoleic acid (CLA) reduces intestinal fatty acid uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and the downstream ERK pathway

Zhang,

Fu,

Wang

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Conjugated linoleic acid (CLA) reduces intestinal fatty acid uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and the downstream ERK pathway

Zhang,

Fu,

Wang

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

“…As described previously [ 9 , 24 , 25 , 26 , 27 ], the study was designed as a parallel, double-blind, randomised controlled trial, registered with the German Clinical Trials Register database (ID: DRKS00010462, date of registration: 4 May 2016) [ 28 ]. The study protocol was approved by the Poznan University of Medical Sciences Ethics Committee (protocol code: 606/12, date of approval: 14 June 2012; protocol code: 453/13, date of approval: 9 May 2013; protocol code: 358/14, date of approval: 3 April 2014; protocol code: 398/15, date of approval: 9 April 2015).…”

Section: Methodsmentioning

confidence: 99%

“…The primary outcome of the study was the effect of CLA supplementation on the digestion of starch and lipids [ 27 ]. Here, we reported the effects of CLA intervention on secondary outcomes, which included the impact on densitometric parameters.…”

Section: Methodsmentioning

confidence: 99%

The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial

Jamka,

Czochralska-Duszyńska,

Mądry

et al. 2023

Medicina

Self Cite

View full text Add to dashboard Cite

Background and Objectives: Conjugated linoleic acid (CLA) can improve bone health in animals, yet the effects on humans have not been consistent. Therefore, this parallel randomised controlled trial aimed to assess the effect of CLA supplementation on bone mineral density (BMD) and content (BMC) in overweight or obese women. Materials and Methods: The study population included 74 women who were divided into the CLA (n = 37) and control (n = 37) groups. The CLA group received six capsules per day containing approximately 3 g of cis-9, trans-11 and trans-10, cis-12 CLA isomers in a 50:50 ratio. The control group received the same number of placebo capsules that contained sunflower oil. BMC and BMD at total body, lumbar spine (L1–L4), and femoral neck were measured before and after a three-month intervention. Results: The comparison of BMC and BMD for the total body, lumbar spine (L1–L4), and femoral neck before and after the intervention showed no differences between the groups. However, a within-group analysis demonstrated a significant increase in BMC (p = 0.0100) and BMD (p = 0.0397) at lumbar spine (L1–L4) in the CLA group. Nevertheless, there were no significant differences between the CLA and placebo groups in changes in all analysed densitometric parameters. Conclusions: Altogether, three-month CLA supplementation in overweight and obese women did not improve bone health, although the short intervention period could have limited our findings, long-term intervention studies are needed. The study protocol was registered in the German Clinical Trials Register database (ID: DRKS00010462, date of registration: 4 May 2016).

show abstract

“…Even more detailed metabolomic studies employed breath analysis-e.g. to determine tricarboxylic acid cycle metabolites [32], omega-oxidation products of aliphatic fatty acids [33], the impact of the conjugated linoleic acid on fat and starch digestion [34] or the impact of nutrition on metabolic pathways [35]. Additionally, the relationship between some of the exhaled breath VOCs and diet-related metabolism disorders has been established [16,[36][37][38].…”

Section: Introductionmentioning

confidence: 99%

Food and lifestyle impact on breath VOCs using portable mass spectrometer—pilot study across European countries

Aleksić,

Simeon,

Vujić

et al. 2023

J. Breath Res.

View full text Add to dashboard Cite

In the modern world, many people are changing old dietary and lifestyle habits to improve the quality of their living – to treat or just prevent possible diseases. The main goal of this pilot study was to assess the food and lifestyle impact on exhaled breath VOCs in various population groups. It was done by employing a recently validated portable membrane-inlet mass spectrometer – MIMS. Thus, the obtained results would also represent the additional confirmation for the employment of the new instrument in the breath analysis. The pilot study involved 151 participants across Europe, including people with overweight, obesity, type 2 diabetes mellitus, cardiovascular disease, people with poor-quality diet and professional athletes. Exhaled breath acetone, ethanol, isoprene, and n-pentane levels were determined in samples before the meal, and 120 min after the meal. Obtained basal ppbv values were mainly in accordance with previously reported, which confirms that MIMS instrument can be used in the breath analysis. Also, for people who have poor-quality diet and professional athletes, these were the first reported findings for the listed breath VOCs. Combining the quantified levels along with the information about the participants' lifestyle habits collected via questionnaire, an assessment of the food and lifestyle impact was obtained. Notable alteration in examined VOC levels upon meal consumption was detected in more than 70 % of all participants, with exception for isoprene, which was affected in about half of participants. Lifestyle parameters impact was examined using ANOVA on ranks test. Statistically significant differences in basal breath VOC levels were observed among all examined population groups. Also, n-pentane and ethanol levels significantly differed in people of different ages, as well as acetone levels in people with different physical activity habits. These findings are promising for further, more focused research using MIMS technique in breath analysis.

show abstract

Conjugated linoleic acid does not affect digestion and absorption of fat and starch—a randomized, double-blinded, placebo-controlled parallel study

Abstract: Supplementation with CLA for 3 months did not affect fat and starch digestion assessed by C mixed triglyceride breath test andC starch breath test.

Cited by 4 publications

References 43 publications

Conjugated linoleic acid (CLA) reduces intestinal fatty acid uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and the downstream ERK pathway

Conjugated linoleic acid (CLA) reduces intestinal fatty acid uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and the downstream ERK pathway

The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial

Food and lifestyle impact on breath VOCs using portable mass spectrometer—pilot study across European countries

Contact Info

Product

Resources

About