Clinical Outcomes of Amniotıc Membrane Transplantatıon in Patients with Corneal and Conjunctival Disorders

Çelik, Tuba; Katircioğlu, Yasemin Arslan; Şingar, Evin; Budak, Koray; Kasim, Remzi; Duman, Sunay

doi:10.3109/08820538.2012.730105

Cited by 8 publications

(6 citation statements)

References 23 publications

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“…It is used for many ocular and conjunctival disorders. 20 of goblet cells and survival of conjunctival epithelium. 20 AM acts directly on ocular surface fibroblasts by suppressing tumor growth factor-beta signals and allowing the formation of the normal keratocyte phenotype not only pathologically, but also physiologically.…”

Section: Discussionmentioning

confidence: 99%

“…20 of goblet cells and survival of conjunctival epithelium. 20 AM acts directly on ocular surface fibroblasts by suppressing tumor growth factor-beta signals and allowing the formation of the normal keratocyte phenotype not only pathologically, but also physiologically. 21 The advantages of AM over the mucous membrane and conjunctival autografts are its anti-inflammatory and anti-infective properties, lack of immunogenicity, unlimited availability, the absence of donor site trauma to the patient, shorter operative time, faster recovery, and matching the color of the surrounding conjunctiva after complete healing because of its translucency.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Results of the Use of Amniotic Membrane Transplantation Alone or in Combination with Adjuvant Therapies in Conjunctival Fornix Reconstruction

Katircioğlu¹,

Kaderli²,

Şingar³

et al. 2022

tjo

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Objectives: To evaluate the clinical results of amniotic membrane transplantation alone or in combination with adjuvant therapies in conjunctival fornix reconstruction. Materials and Methods: The clinical results of patients who presented to our clinic between 2002 and 2016 due to conjunctival fornix obliteration and underwent amniotic membrane transplantation alone or in combination with additional treatments were retrospectively analyzed. The Foster and Mondino classifications were used to grade fornix obliteration. In all cases, the area of conjunctival defect formed after symblepharon lysis was covered with amniotic membrane. In advanced fornix obliteration, amniotic membrane transplantation was combined with 0.04% mitomycin-C (MMC), oral mucosal transplantation, fornix formation (anchoring) sutures, symblepharon ring, eyelid surgery, fibrin glue, and limbal autograft. Deep and scarless restoration of the fornix was considered surgical success. Results: Twenty-two men and 5 women with a mean age of 45.54±4.17 years were included in the study. The etiology of fornix obliteration was mechanical trauma in 16 cases, chemical burn in 6 cases, recurrent pterygium in 3 cases, thermal burn in 1 case, and recurrent chalazion surgery in 1 case. Indications for amniotic membrane transplantation were socket insufficiency in 12 cases, cosmetic reasons in 4 cases, keratoplasty preparation in 3 cases, ptosis in 3 cases, entropion in 2 cases, strabismus in 2 cases, and diplopia in 1 case. The mean follow-up period was 45.04±8.4 months. Twenty-four of 27 cases (88.8%) were successful, while 3 (12.2%) failed due to recurrence of symblepharon. Conclusion: Amniotic membrane transplantation is a successful method when used alone in the reconstruction of early-stage conjunctival fornix obliteration and provides safe and effective results in advanced-stage fornix obliteration when performed in combination with topical 0.04% MMC, oral mucosal transplantation, and limbal autograft surgeries.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical Results of the Use of Amniotic Membrane Transplantation Alone or in Combination with Adjuvant Therapies in Conjunctival Fornix Reconstruction

Katircioğlu¹,

Kaderli²,

Şingar³

et al. 2022

tjo

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“…Unfortunately, complications caused by the resection of conjunctival lesions are frequently seen, including symblepharon, scarring, and a partial or total limbal stem cell deficiency. 17 , 18 Moreover, conjunctival scarring could lead to reduced motility of the globe, resulting in diplopia. The main concern for the surgeon in these challenging situations is to find a suitable graft for reconstructing the resected area to avoid the complications listed earlier.…”

Section: Discussionmentioning

confidence: 99%

Surgical management of a conjunctival nevus with amniotic membrane transplantation

Röck¹,

Bösmüller²,

Bartz‐Schmidt³

et al. 2018

IMCRJ

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PurposeNevi of the conjunctiva are usually benign pigmented tumorous lesions located in the bulbar conjunctiva. In most conjunctival nevus cases, the patient wants the lesion to be removed for cosmetic reasons, but excisional biopsies are best for lesions suspicious for malignancy. This case report illustrates the intraoperative surgical management, histological findings, and the course of healing in a conjunctival nevus patient.Case reportA 26-year-old man was referred to our eye hospital with a large bulbar conjunctival nevus of the right eye. Upon examination, there was a large pigmented lesion with numerous small cysts present on the superior bulbar conjunctiva. The conjunctival tumor was resected, and an amniotic membrane transplantation was performed for the bulbar conjunctival reconstruction. The histopathological diagnosis suggested a conjunctival nevus. After the resection, a reduction in the inflammation and healing of the conjunctival lesion could be seen. The epithelialization of the bulbar conjunctiva over the amniotic membrane was complete 4 weeks after the resection. At the 6-month follow-up, there was no sign of recurrence or any postoperative complications.ConclusionA surgical excision combined with reconstruction via amniotic membrane transplantation is effective and economical for the treatment of large conjunctival lesions.

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“…So, the treatment of corneal perforations may be much attentive with a filling scaffold material, which constructs the structure of defect site and maintains sufficient time for an adequate penetrating keratoplasty. AMT has been used to treat ocular surface epithelial disorders, to restore corneal stromal thickness and to treat small-sized corneal perforations [9, 14]. AMT and scleral patches, if it is hard to maintain AMT, are very useful to avoid an urgent penetrating keratoplasty, which has a limited success rate in acute cases [15, 16].…”

Section: Discussionmentioning

confidence: 99%

Simplified Technique for Sealing Corneal Perforations Using a Fibrin Glue-Assisted Amniotic Membrane Transplant-Plug

Kara

Arıkan

Erşan

et al. 2014

Case Reports in Ophthalmological Medicine

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Purpose. To describe a surgical technique using amniotic membrane transplant (AMT) with fibrin glue (FG) for treating smaller corneal perforations more practically and appropriately filling the defect. Method. A patient with noninfectious central corneal perforation, in 1 mm in diameter, was treated with FG-assisted AMT-plug. An AMT was folded in on itself twice by using FG then a small piece of this FG-AMT mixture was cut to maintain an appropriate plug for the site of the corneal perforation. The FG-assisted AMT-plug was placed in the perforation area by using FG. An amniotic membrane patch was placed over the plug, which was then secured by a bandage contact lens. Result. Surgery to restore corneal stromal thickness without recurrence of perforation. Conclusion. The FG-assisted AMT-plug allowed a successful repair of 1 mm in diameter corneal perforation. This technique was easily performed, thus seeming to be a good alternative to treat corneal perforations with restoring corneal thickness.

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Clinical Outcomes of Amniotıc Membrane Transplantatıon in Patients with Corneal and Conjunctival Disorders

Abstract: AMT is effective to promote corneal healing in patients with persistent epithelial defect and appeared to be helpful after surgery to release pain. It can be successfully used as an alternative to conjunctival autograft for conjunctival surface reconstruction.

Cited by 8 publications

References 23 publications

Clinical Results of the Use of Amniotic Membrane Transplantation Alone or in Combination with Adjuvant Therapies in Conjunctival Fornix Reconstruction

Clinical Results of the Use of Amniotic Membrane Transplantation Alone or in Combination with Adjuvant Therapies in Conjunctival Fornix Reconstruction

Surgical management of a conjunctival nevus with amniotic membrane transplantation

Simplified Technique for Sealing Corneal Perforations Using a Fibrin Glue-Assisted Amniotic Membrane Transplant-Plug

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