Clinical Results of the Use of Amniotic Membrane Transplantation Alone or in Combination with Adjuvant Therapies in Conjunctival Fornix Reconstruction

Katircioğlu, Yasemin A.; Kaderli, Ahmet; Şingar, Evin; Örnek, Firdevs

doi:10.4274/tjo.galenos.2021.77019

Cited by 3 publications

(7 citation statements)

References 34 publications

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“…Amniotic membrane transplantation has been successfully described as an alternative to MMG to address forniceal deformities in patients with foreshortening, cyst formation, and symblepharon. [36][37][38][39]41,87 The first published case report described using amniotic membrane to lengthen the fornix in a patient with prior Stevens-Johnson syndrome in whom buccal mucosa was not available. 36 Since then, several case reports and case series have been published that describe the use of amniotic membrane transplantation to address forniceal foreshortening to allow the placement of an ocular prosthesis.…”

Section: Socket Contracturementioning

confidence: 99%

“…89 AMT can also be used in combination with other surgical techniques, including oral mucosal transplantation or placement of a symblepharon ring. 38,40 Ultra-thick amniotic membrane grafting has successfully been used in a few cases of anophthalmic socket contracture. 18 Although it has not formally been studied, the authors suggest that the ultra-thick graft may have a lower rate of graft dehiscence compared to placental amniotic membrane grafts.…”

Section: Socket Contracturementioning

confidence: 99%

Section: Eyelid and Fornixmentioning

confidence: 99%

“…89 AMT can also be used in combination with other surgical techniques, including oral mucosal transplantation or placement of a symblepharon ring. 38,40…”

Section: Eyelid and Fornixmentioning

confidence: 99%

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A Review of Current Uses of Amniotic Membrane Transplantation in Ophthalmic Plastic and Reconstructive Surgery

Parikh,

Conger,

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To review and summarize the existing literature on the clinical applications of amniotic membrane transplantation (AMT) in ophthalmic plastic and reconstructive surgery. Methods: A literature review was conducted on the PubMed database using the following search terms: “amniotic membrane” and “eyelid” or “orbit” or “fornix” or “socket” or “lacrimal”. Results: In total 516 articles resulted from the search, of which 62 were included. Numerous cases and case series have been published on the use of amniotic membrane transplantation for ocular surface reconstruction, eyelid and forniceal reconstruction, and cicatricial eyelid abnormalities. Surgical methods of securing the graft vary. Few comparative studies exist; some show a similar or improved result when compared to oral mucous membrane grafting for certain indications. Conclusions: Amniotic membrane transplantation can be a useful tool for the oculoplastic surgeon when faced with a case requiring reconstruction of the posterior lamellae, particularly in patients without other graft donor sites available, and uses of AMT continue to expand. Additional studies directly comparing AMT to other reconstructive techniques would be helpful in choosing between the available surgical techniques and standardizing best practices.

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Section: Socket Contracturementioning

confidence: 99%

Section: Socket Contracturementioning

confidence: 99%

Section: Eyelid and Fornixmentioning

confidence: 99%

“…89 AMT can also be used in combination with other surgical techniques, including oral mucosal transplantation or placement of a symblepharon ring. 38,40…”

Section: Eyelid and Fornixmentioning

confidence: 99%

See 2 more Smart Citations

A Review of Current Uses of Amniotic Membrane Transplantation in Ophthalmic Plastic and Reconstructive Surgery

Parikh,

Conger,

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…[5][6][7] The use of human amniotic membrane has also been described for management of socket contracture recently with a good outcome. 8 We hypothesize that ultra-thick human umbilical amniotic membrane transplant (AMT) is a valid alternative to mucous membrane graft or placental amnion for the management of an ophthalmic socket contracture. Pregnant women and patients with active inflammation and infection were excluded.…”

Section: Introductionmentioning

confidence: 99%

Clinical use of cryopreserved ultra-thick human amniotic membrane for anophthalmic socket contracture

AlSemari,

AlZahrani,

Ahad

et al. 2023

European Journal of Ophthalmology

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Purpose To study the use of ultra-thick human amniotic membrane for management anophthalmic socket contracture. Methods A prospective study done at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Thirty-six patients (45 eyelids) were involved. Contracted socket caused by trauma, previous surgery or radiotherapy, delay in use of prosthesis, Congenital Anophthalmia/Microphthalmia, and Anophthalmia secondary to Enucleation/Evisceration were included in the study. Results Thirty-three patients (42 eyelids) underwent fornix reconstruction with cryopreserved ultra-thick human amniotic membrane. Mean ± SD age at surgery was (40.90 ± 17.32) years. Mean follow up was 10.5 months. Grade II fornix contracture was the most common type in 23 (54.8%) eyelids. The most common involved primary diagnosis was Anophthalmia secondary to Enucleation/Evisceration (n = 13). The incidence of pyogenic granuloma (PG) after surgery was seen in 8 eyelids (19.0%). Conclusion Anophthalmic contracted socket secondary to significant history of multiple PG excision (> 5 times) and secondary to enucleation/evisceration were associated with good surgical outcome. Cryopreserved ultra-thick human amniotic membrane is an ideal material for the management of anophthalmic socket contracture.

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Decellularized Porcine Conjunctiva in Treating Severe Symblepharon

Shan

Feng

et al. 2023

JFB

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This prospective study aimed to evaluate the effectiveness of decellularized porcine conjunctiva (DPC) in the management of severe symblepharon. Sixteen patients with severe symblepharon were enrolled in this study. After symblepharon lysis and Mitomycin C (MMC) application, tarsus defects were covered with residual autologous conjunctiva (AC), autologous oral mucosa (AOM), or DPC throughout the fornix, and DPC was used for all the exposed sclera. The outcomes were classified as complete success, partial success, or failure. Six symblepharon patients had chemical burns and ten had thermal burns. Tarsus defects were covered with DPC, AC, and AOM in two, three, and eleven cases, respectively. After an average follow-up of 20.0 ± 6 months, the anatomical outcomes observed were complete successes in twelve (three with AC+DPC, four with AC+AOM+DPC, and five with AOM+DPC) (75%) cases, partial successes in three (one with AOM+DPC and two with DPC+DPC) (18.75%) cases, and failure in one (with AOM+DPC) (6.25%) case. Before surgery, the depth of the narrowest part of the conjunctival sac was 0.59 ± 0.76 mm (range, 0–2 mm), tear fluid quantity (Schirmer II tests) was 12.5 ± 2.26 mm (range, 10–16 mm), and the distance of the eye rotation toward the opposite direction of the symblepharon was 3.75 ± 1.39 mm (range, 2–7 mm). The fornix depths increased to 7.53 ± 1.64 mm (range, 3–9 mm), eye movement was significantly improved, and the distance of eye movement reaching 6.56 ± 1.24 mm (range, 4–8 mm) 1 month after the operation; the postoperative Schirmer II test (12.06 ± 2.90 mm, range, 6–17 mm) was similar to that before surgery. Goblet cells were finally found in fifteen patients by conjunctival impression cytology in the transplantation area of DPC, except for one patient who failed. DPC could be considered an alternative for ocular surface reconstruction of severe symblepharon. Covering tarsal defects with autologous mucosa is necessary for extensive reconstruction of the ocular surface.

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Clinical Results of the Use of Amniotic Membrane Transplantation Alone or in Combination with Adjuvant Therapies in Conjunctival Fornix Reconstruction

Cited by 3 publications

References 34 publications

A Review of Current Uses of Amniotic Membrane Transplantation in Ophthalmic Plastic and Reconstructive Surgery

A Review of Current Uses of Amniotic Membrane Transplantation in Ophthalmic Plastic and Reconstructive Surgery

Clinical use of cryopreserved ultra-thick human amniotic membrane for anophthalmic socket contracture

Decellularized Porcine Conjunctiva in Treating Severe Symblepharon

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