Clinical Outcomes and Survival of HIV Positive and Negative Patients on LVAD Support

Systematic Review of Advanced Heart Failure Therapy Outcomes in People With Human Immunodeficiency Virus

“…Three-year survivorship data were reported for the heart transplant studies, 1 , 4 and 2-year survivorships were reported for LVAD studies. 2 , 3 These longer-term data were also comparable between PLWH and HIV-negative patients ( Figure 1B ).

Figure 1 Mortality and Survivorship for PLWH and HIV-Negative Patients on Advanced Therapies (A) One-year mortality after HT or LVAD and (B) longer-term survivorship after HT (3 years) or LVAD (2 years) among PLWH and HIV-negative controls.

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“…The final analysis comprised 95 PLWH who received HT (mean age 49 years) and 107 PLWH who received LVAD (mean age 53 years), as well as 39,002 patients without HIV who received HT (mean age 54 years) and 26,346 patients without HIV who received LVAD (mean age 59 years). 1 , 2 , 3 , 4 The HIV patients were about 5 years younger than HIV-negative patients among those who had HT or LVAD. Racial composition differed between the PLWH (53% White, 38% Black) and HIV-negative patients (70% White, 20% Black) who received HT.…”

State‐of‐the‐art document on optimal contemporary management of cardiomyopathies

“…Despite concerns that immunosuppression following heart transplantation may worsen HIV infection, growing body of data suggests no post‐transplant deterioration in HIV status, 97 suggesting that heart transplantation could be an option in selected patients with advanced HF 98 . There are also data supporting the use of LV assist devices in patients with HIV‐associated cardiomyopathy, 99 which warrant confirmation from larger studies.…”