“…Majority of current approaches in 'targeted' therapies or 'personalized' medicine focus on utilization of potent apoptosis-inducing factors (poisons) to inhibit specific events in numerous growth pathways that are involved in support of tumorigenesis (Alberts et al, 2011, Arguello 2011, Bannar and Gerner 2011, Boon et al, 2006, Cataldo et al, 2011, Chen et al, 2011, Coss et al, 2011, Del Fabbro et al, 2011, Florescu et al, 2011, Innocenti et al, 2011a, b, Lesterhuis etal, 2011, Nishioka et al, 2011, Nyakern et al, 2006, Osborne et al, 2004, Ramsdale et al, 2011, Rove and Flaig 2010, Zitvogel et al, 2008. These drugs [e.g., apoptotic factors (TNF-, monoclonal antibodies against growth factors or enzymes (e.g., VEGF, kinases), mutated genes, epigenetic modifications, etc] introduce additional oxidative stress ('immune tsunami') to an already immune-compromised body, causing additional damage not only to the primary target tissue, but also to other tissues, resulting in devastating side effects, such as cancer-associated cachexia, anorexia, sarcopenia, severe inflammation, venous thromoembolism, diarrhea, excessive loss of appetite and weight, drug-resistance and cancer relapse and multiple organ failure (MOF).…”