Clinical outcomes after treatment of intra‐bony defects with an EMD/synthetic bone graft or EMD alone: a multicentre randomized‐controlled clinical trial

Jepsen, Søren; Topoll, Heinz; Rengers, H.; Heinz, Bernd; Teich, M.; Hoffmann, Thomas; Al-Machot, Elyan; Meyle, Joerg; Jervøe‐Storm, Pia‐Merete

doi:10.1111/j.1600-051x.2008.01217.x

Cited by 62 publications

(132 citation statements)

References 41 publications

(51 reference statements)

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“…EMD may influence softtissue healing, which may cause better postoperative patient perceptions, in addition to its capability of promoting periodontal regeneration 1,12,18,24) . Lack of pain, improved healing of the soft tissues and limited inflammation of the operated areas have been common clinical observations following EMD therapy 8,9) . Ozcelik et al 14) reported that patient perceptions on the immediate post-operative period were significantly better in the non-surgery and surgery with EMD groups when compared with the surgery group.…”

Section: Discussionmentioning

confidence: 99%

“…While it is imperative to evaluate the efficacy of a treatment modality in longitudinal studies, it is equally important to understand the healing process during early periods. It is assumed that EMD has an effect on the critical steps of periodontal wound healing that occur during the early healing phase 9) . In our teaching hospital, surgical treatment with EMD has been the treatment of choice for patients requesting periodontal regenerative therapy.…”

Section: Introductionmentioning

confidence: 99%

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Treatment of Periodontal Defects with Enamel Matrix Derivative: Clinical Evaluation at Early Healing Stages

Saitô

Hayakawa

Ota

et al. 2010

Bull. Tokyo Dent. Coll.

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The aim of this retrospective clinical study was to evaluate the treatment of intrabony periodontal defects with enamel matrix derivative (EMD) during the early stages of healing. Sixteen patients aged 38-77 years with a clinical diagnosis of chronic periodontitis were subjected to data analysis. A total of 25 teeth with various osseous defects received regenerative therapy with EMD, and were followed for a minimum of 6 months. Post-operative healing was uneventful in the majority of cases. Treatment of the intrabony defects with EMD led to a statistically significant improvement in the mean value of probing depth at 3 months compared with that at baseline (pϽ0.001). Mean values of attachment gain at 3 and 6 months were of clinical significance: ‫8.1ע6.3‬ mm and ‫5.1ע2.3‬ mm, respectively. Reduction in probing depth was achieved with minimal recession of gingival margin and was sustained over a time course of 6 months. A progressive increase in radiopacity, suggestive of initial signs of bone-fill, was observed by 6 months. In summary, the results suggest that treatment of intrabony defect with EMD induces favorable periodontal healing with a high level of predictability.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Treatment of Periodontal Defects with Enamel Matrix Derivative: Clinical Evaluation at Early Healing Stages

Saitô

Hayakawa

Ota

et al. 2010

Bull. Tokyo Dent. Coll.

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“…Enamel matrix derivative is derived from porcine tooth buds and is currently available in a commercial formulation (Emdogain ® Gel, Biora AB, Malmö, Sweden) 3) . Since its introduction, extensive research regarding EMD has been carried out, and the results have demonstrated its ability to encourage periodontal regeneration 4,6,7,17,22) . There was, however, a substantial degree of variability in treatment outcome with a pronounced center effect 4,13) .…”

Section: Introductionmentioning

confidence: 99%

Two-year Follow-up of Treatment of Intrabony Periodontal Defect with Enamel Matrix Derivative

Fujinami

Hayakawa

Ota

et al. 2011

Bull. Tokyo Dent. Coll.

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The aim of this retrospective clinical study was to evaluate 2-year follow-up results following regenerative periodontal surgery for intrabony defects using enamel matrix derivative (EMD). Thirteen patients (mean age: 53 years) with a clinical diagnosis of chronic periodontitis were subjected to data analysis. A total of 25 sites with intrabony defects received regenerative therapy with EMD. Follow-up continued for a minimum of 2 years. Treatment of intrabony defects with EMD yielded a statistically significant improvement in the mean values of probing depth and gains in clinical attachment level (CAL) at 2 years compared with those at baseline (pϽ0.001). Sites treated with EMD demonstrated a mean CAL gain of 3.4 mm and 3.2 mm at 6 months and 2 years, respectively. No statistically significant difference in gain in CAL was found between the 6-month and 2-year results. A gain in CAL of Ն3 mm from at baseline was found in 17 sites at 2 years. This gain was achieved with minimal recession of gingival margin and was sustained over a given period of time. A trend toward a progressive increase in radiopacity, suggestive of bone-fill, was observed. In summary, treatment of intrabony defects with EMD resulted in clinically favorable outcomes. The clinical improvements obtained with regenerative therapy with EMD were maintained over a period of 2 years.

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“…According to a study of Jepsen et al [19] it has been shown that the clinical outcomes after treatment of intra-bony defects with an EMD/synthetic bone graft or EMD alone could bring similar but good results considering the shape of the defects. In our case, a remarkable improvement of the GR, PD and CAL records were achieved.…”

Section: Discussionmentioning

confidence: 99%

“…Gingival recession has been especially correlated with lip studs or labrets [1,4,15,16] and frequently occurs on the labial aspect of the lower central incisors [3,4,[16][17][18][19][20][21]. Gingival recession, particularly on the lingual aspect of the mandibular anterior teeth, has also been associated with tongue piercing [3,4,16,17].…”

Section: Introductionmentioning

confidence: 99%

Treatment Strategy for Correction of Periodontal Defects Associated with Tongue Piercing: A Case Report

Gassmann¹

2014

J Interdiscipl Med Dent Sci

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Intraoral piercing has increased in popularity in the last few years. This type of jewelry has been associated with periodontal and muco-gingival defects such as attachment loss and gingival recession. This case report described a 25-year-old female presented to the clinic of Periodontics at Witten/Herdecke University in Witten, Germany, with a tongue stud placed through the mid-dorsum of her tongue. The lower left central (LL1) and lower right central (LR1) incisors exhibited 6 mm and 5 mm lingual probing depth, 4mm and 3.5mm lingual recession respectively and localized radiographic bone loss in the mid-half of the roots. The treatment strategy consisted of removal of the tongue piercing, professional prophylaxis, oral hygiene instructions and an open-flap surgery of the lingual anterior region of the mandible with the application of enamel matrix derivative (EMD) and bone graft material. Results: At the 1-, 3-and 7-month recall visits, the patient's oral hygiene has been improved, and the attachment loss appears to have stabilized. It is clear that the tongue piercing might be a risk factor for local periodontal complications.

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Clinical outcomes after treatment of intra‐bony defects with an EMD/synthetic bone graft or EMD alone: a multicentre randomized‐controlled clinical trial

Abstract: The results of the present study showed similar clinical outcomes following both treatment modalities.

Cited by 62 publications

References 41 publications

Treatment of Periodontal Defects with Enamel Matrix Derivative: Clinical Evaluation at Early Healing Stages

Treatment of Periodontal Defects with Enamel Matrix Derivative: Clinical Evaluation at Early Healing Stages

Two-year Follow-up of Treatment of Intrabony Periodontal Defect with Enamel Matrix Derivative

Treatment Strategy for Correction of Periodontal Defects Associated with Tongue Piercing: A Case Report

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