Clinical outcomes after intravascular ultrasound and fractional flow reserve assessment of intermediate coronary lesions. Propensity score matching of large cohorts from two institutions with a differential approach

Palop, Ramón Lopéz; Camarero, Tamara García; Sáez, Pilar Carrillo; Gorría, Gonzalo Martín; Garcia, Araceli Frutos; Corada, Blanca Arnaez; Cordero, Alberto; Delgado, Jenny M Gomez; Quílez, Pilar Agudo; Lee, Dae-Hyun; Rodriguez, Irene Mateo; Laso, Fermín Sáinz; Khashaba, Ahmed; Arques, Sandra Miralles; Gil, Javier Zueco

doi:10.4244/eijv9i7a136

Cited by 19 publications

(13 citation statements)

References 22 publications

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“…Thus, we have conducted a similar analysis involving the use of this new parameter: acute drop Pd/Pa‐NTG. In our multicenter study the average FFR measurements and proportion of significant values are in accordance with those reported in previous large experiences from real practice . An excellent correlation has been found between acute drop Pd/Pa‐NTG and FFR with a cut‐off value of >0.88 associated with very high NPV (96.2% for FFR < 0.8 and 100% for FFR < 0.75).…”

Section: Discussionsupporting

confidence: 90%

The use of the acute Pd/Pa drop after intracoronary nitroglycerin infusion to rule out significant FFR: CANICA (Can intracoronary nitroglycerin predict fractional flow reserve without adenosine?) multicenter study

Martín-Reyes

Peláez

Palop

et al. 2015

Cathet Cardio Intervent

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Section: Discussionsupporting

confidence: 90%

The use of the acute Pd/Pa drop after intracoronary nitroglycerin infusion to rule out significant FFR: CANICA (Can intracoronary nitroglycerin predict fractional flow reserve without adenosine?) multicenter study

Martín-Reyes

Peláez

Palop

et al. 2015

Cathet Cardio Intervent

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“…The PS Matching program performs all analyses in R through the SPSS-R Plugin (Thoemmes F, 2011) – an SPSS R menu for propensity score matching. [ 10 , 11 ]. Variables for which the unadjusted p value was < 0.10 were identified in multivariate logistic regression analysis as potential risk markers and included in the full model.…”

Section: Methodsmentioning

confidence: 99%

Relationship of platelet indices with acute stent thrombosis in patients with acute coronary syndrome

Ballı¹,

Taşolar²,

Çetın³

et al. 2015

pwki

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IntroductionDespite major advances in stent technology and antithrombotic therapy, the development of stent thrombosis continues to be a major problem in patients who have undergone percutaneous coronary intervention (PCI). Although a few studies have investigated the relationship between early stent thrombosis and platelet activity, the relationship between acute stent thrombosis (AST) (within the first 24 h) and platelet indices is unclear.AimWe investigated the relationship between AST development and platelet indices in acute coronary syndrome patients.Material and methodsIn our case-control study, 33 patients who underwent PCI with subsequent AST development and 59 patients without AST were selected by propensity analysis. We compared the clinical, angiographic, and laboratory data between the AST and control groups.ResultsMean platelet volume (MPV) (p=0.002) and platelet distribution width (p=0.014) were significantly higher and platelet count (p=0.017) was significantly lower in the AST group. Logistic regression analyses showed that MPV was a significant independent predictor of AST (OR = 1.67; 95% CI: 1.11–2.51; p=0.013). In the ROC analyses, the cut-off value of MPV to detect AST was > 9.1 fl with a sensitivity of 90.9%, a specificity of 42.4%, a positive predictive value of 46.9% and a negative predictive value of 89.3% (AUC: 0.687, 95% CI: 0.582–0.780, p=0.001).ConclusionsOur study shows that baseline MPV predicts the development of AST in patients with ACS. Mean platelet volume therefore might be an easily accessible marker in the identification of patients at high risk for the development of AST.

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“…Alltogether this suggests that most of the vulnerable intermediate lesions are already treated based on FFR measurements anyway, but it should be noted that a high consternation of necrotic core was also observed in FFR negative lesions [14]. Clinical observations presented similar clinical outcomes for the coronary lesion discrimination by IVUS or FFR [16], despite the limited utility of IVUS measurements to guide intervention [17]. Similar clinical outcomes for IVUS and FFR guided interventions suggest that some of IVUS guided intervention were preformed in FFR-negative vulnerable lesions, which brought benefit to patients.…”

Section: Discussionmentioning

confidence: 66%

Multimodality imaging of intermediate lesions: Data from FFR, OCT, NIRS-IVUS

et al. 2013

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Clinical outcomes after intravascular ultrasound and fractional flow reserve assessment of intermediate coronary lesions. Propensity score matching of large cohorts from two institutions with a differential approach

Abstract: IVUS and FFR may be safely used to defer revascularisation of intermediate lesions. IVUS induces a higher degree of revascularisation but much lower than previously reported and does not affect the clinical outcome.

Cited by 19 publications

References 22 publications

The use of the acute Pd/Pa drop after intracoronary nitroglycerin infusion to rule out significant FFR: CANICA (Can intracoronary nitroglycerin predict fractional flow reserve without adenosine?) multicenter study

The use of the acute Pd/Pa drop after intracoronary nitroglycerin infusion to rule out significant FFR: CANICA (Can intracoronary nitroglycerin predict fractional flow reserve without adenosine?) multicenter study

Relationship of platelet indices with acute stent thrombosis in patients with acute coronary syndrome

Multimodality imaging of intermediate lesions: Data from FFR, OCT, NIRS-IVUS

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