Abstract:This was a retrospective analysis of patients who had CABG surgery at our hospital over a 12-month period to determine the intermediate-term prognosis of those who had developed PAF after their operation before hospital discharge. Of 317 patients who were operated by a single surgical group, 116 (37%) had AF postoperatively of whom 112 had the paroxysmal form. Of these, 36 were treated with class I or III antiarrhythmic drugs and rate control drugs (group 1) and 76 were treated with rate control alone (group 2… Show more
“…Other abbreviations as in Table 1. 26 Elahi et al reported a POAF incidence of 14% in the immediate postoperative period, 2% at 6 weeks and 1% at 1 year postoperatively. 5 These studies, however, collected information retrospectively, and in the Elahi et al study, data on late follow-up were collected via telephone national guidelines encouraging a prescription of antiplatelet therapy only.…”
“…Other abbreviations as in Table 1. 26 Elahi et al reported a POAF incidence of 14% in the immediate postoperative period, 2% at 6 weeks and 1% at 1 year postoperatively. 5 These studies, however, collected information retrospectively, and in the Elahi et al study, data on late follow-up were collected via telephone national guidelines encouraging a prescription of antiplatelet therapy only.…”
“…[1][2][3] Postoperative AF after cardiac surgery can cause a number of complications, including congestive heart failure, stroke, and hemodynamic instability. It is responsible for increased hospital costs and prolonged hospitalization.…”
mentioning
confidence: 99%
“…It is responsible for increased hospital costs and prolonged hospitalization. [1][2][3] This tachyarrhythmia usually occurs within 1 week after cardiac surgery and generally resolves over the first 3 weeks after cardiac surgery. Previous studies have shown that the peak incidence of early postoperative AF is on the second postoperative day after CABG.…”
Background—
Atrial fibrillation (AF) is common after cardiac surgery. Abnormal conduction is an important substrate for AF. We hypothesized that atrial inflammation alters atrial conduction properties.
Methods and Results—
Normal mongrel canines (n=24) were divided into 4 groups consisting of anesthesia alone (control group); pericardiotomy (pericardiotomy group); lateral right atriotomy (atriotomy group); and lateral right atriotomy with antiinflammatory therapy (methylprednisolone 2 mg/kg per day) (antiinflammatory group). Right atrial activation was examined 3 days after surgery. Inhomogeneity of conduction was quantified by the variation of maximum local activation phase difference. To initiate AF, burst pacing was performed. Myeloperoxidase activity and neutrophil cell infiltration in the atrial myocardium were measured to quantify the degree of inflammation. The inhomogeneity of atrial conduction of the atriotomy and pericardiotomy groups was higher than that of the control group (2.02±0.10, 1.51±0.03 versus 0.96±0.08, respectively;
P
<0.005). Antiinflammatory therapy decreased the inhomogeneity of atrial conduction after atriotomy (1.16±0.10;
P
<0.001). AF duration was longer in the atriotomy and pericardiotomy groups than in the control and antiinflammatory groups (
P
=0.012). There also were significant differences in myeloperoxidase activity between the atriotomy and pericardiotomy groups and the control group (0.72±0.09, 0.41±0.08 versus 0.18±0.03 ΔOD/min per milligram protein, respectively;
P
<0.001). Myeloperoxidase activity of the antiinflammatory group was lower than that of the atriotomy group (0.17±0.02;
P
<0.001). Inhomogeneity of conduction correlated with myeloperoxidase activity (
r
=0.851,
P
<0.001).
Conclusions—
The degree of atrial inflammation was associated with a proportional increase in the inhomogeneity of atrial conduction and AF duration. This may be a factor in the pathogenesis of early postoperative AF. Antiinflammatory therapy has the potential to decrease the incidence of AF after cardiac surgery.
“…It typically occurs between the first and the fifth day following surgery with frequency peak on the second day [2]. Although it is well tolerated in the majority of the patients [3], AF can result in hemodynamic instability, especially in those patients with left ventricular diastolic dysfunction because they present a reduced tolerance to the loss of atrial contraction [4]. Limiting the use of betablockers and amiodarone [5,6], as a prophylactic pharmacological measurement of postoperative AF, have induced studies regarding prophylactic nonpharmacological measurements.…”
Efeitos da estimulação temporária atrial direita na prevenção da fibrilação atrial no pós-operatório de revascularização do miocárdio com circulação extracorpórea Effect of temporary right atrial pacing in prevention of atrial fibrillation after coronary artery bypass graft surgery Abstract Objective: To evaluated the effects of temporary atrial pacing to prevent the atrial fibrillation following coronary artery bypass graft surgery and the risk factors to the occurrence of this arrhytmia.Methods: We have studied 160 patients who, at the end of coronary artery bypass graft surgery, were submitted to epicardial electrode implantation in the right atrium lateral wall. They were randomized into two groups: non-pacing (NP) group and right atrial (RA) pacing group. The cardiac rhythm was monitorized over 72 hours following to the end of surgery and the variables studied were as follow: incidence of atrial fibrillation; the risk factors pre-, intra-, and postoperative for its occurrence, and postoperative events.Results: There were 21 (13.1%) episodes of atrial fibrillation, 20 in the NP group and one in the RA group. The relative risk (RR) for the development of atrial fibrillation was 0.18 (95% CI; 0.05-0.60) for the RA group 333 AVILA NETO, V ET AL -Effect of temporary right atrial pacing in prevention of atrial fibrillation after coronary artery bypass graft surgery Bras Cir Cardiovasc 2007; 22(3): 332-340
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