Clinical outcome after insemination with donor sperm in patients with poor results in ICSI cycles

Abstract

The introduction of intracytoplasmic sperm injection (ICSI) provided an effective treatment for infertile couples whose infertility was attributed to male factors. However, some of them face poor results after ICSI and subsequently use artificial insemination with donor sperm (AID). Only a few studies have reported on the clinical outcome of AID cycles after previous failed ICSI cycles, with contrasting results. The results reported here involve a cohort of 47 couples undertaking 175 AID cycles after 120 failed ICSI cycles for various reasons. Couples were allocated to two groups according to the availability of top quality embryos (TQE) in ICSI cycles. In our series, AID was successful for couples with and without TQE previously transferred in ICSI cycles, the live birth rate (LBR) per cycle being 20.0% and 13.3%, respectively. However, couples with TQE tended to succeed more rapidly than couples with poor quality embryos, with a higher cumulative LBR (68.0% versus 54.5%, respectively). These findings demonstrate that even couples with a history of unsuccessful ICSI cycles because of poor embryo quality are able to achieve high LBR after AID cycles. However, such couples have a lower cumulative LBR and are required to be more patient to achieve parenthood.

Successful approach for couples having their own genetic offspring using vitrified‐warmed oocytes injected by frozen‐thawed poor quality testicular sperm: A case report

“…However, after injection of the vitrified‐warmed sibling oocytes, with frozen‐thawed donor sperms, the pregnancy and live birth were achieved 1 . Similar to this case, when the ejaculated sperms or TESE sample have poor quality or resulted in unsatisfactory clinical outcomes, the use of a third person's sperm is recommended in almost all IVF centers worldwide 13 …”

“…1 Similar to this case, when the ejaculated sperms or TESE sample have poor quality or resulted in unsatisfactory clinical outcomes, the use of a third person's sperm is recommended in almost all IVF centers worldwide. 13 Assisted reproductive technology therapies are offered to infertile couples in ways shaped by their local considerations, including their social, cultural, religious, economic, ethical, and political circumstances. In this case, we had to inject immotile sperms with a severe morphological abnormality due to the limitation of the use of the donor sperm.…”

Live birth after transfer of vitrified-warmed embryo derived from vitrified-warmed oocyte and frozen-thawed sperm following failed ICSI: Case report

“…However, some of infertile couples face poor results after ICSI and subsequently use artificial insemination with donor sperm. These couples with a history of unsuccessful ICSI cycles because of poor embryo quality are able to achieve high live birth rate after AID cycles 12 . Ghoraeian et al 13 demonstrated that men especially with severe oligozoospermia have an elevated risk for chromosome abnormalities in their spermatozoa.…”