Clinical Observations Regarding Sliding Hiatal Hernia

Meadows, Charles

doi:10.1378/chest.47.6.629

Cited by 8 publications

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“…'-" Reported mechanisms by which GOR and asthma may be related include (1) activation by GOR of a vagal reflex arc from the oesophagus to the lung resulting in bronchoconstriction'0 1224; and (2) microaspiration of gastric contents into the lung resulting in an exudative mucosal reaction.8 18 25 26 Indeed, reports showing a reduction, or even disappearance of the asthma with surgical repair or medical management of the reflux have further strengthened support for a GOR-asthma association.27 30 Our results do not clarify the nature of the GOR-asthma relation or the mechanisms of reflux induced asthma. The high frequency with 100 Figure 5: Hiatal hernia and grade ofoesophageal mucosa in patients with asthma.…”

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confidence: 99%

Prevalence of oesophagitis in asthmatics.

Sontag

Schnell

Miller

et al. 1992

Gut

165

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The exact relation between gastro-oesophageal reflux and asthma remains poorly understood. To determine whether gastro-oesophageal reflux in asthmatics results in oesophagitis, endoscopy and oesophageal biopsy were performed on 186 consecutive adult asthmatics. The presence or absence of reflux symptoms was not used as a selection criterion for asthmatics. Endoscopy was performed by two endoscopists using predefined criteria. All asthmatics had discrete wheezing and either a previous diagnosis of asthma or

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confidence: 99%