Epidemiologie und Spontanverlauf der Refluxkrankheit

Sonnenberg, Amnon

doi:10.1007/978-3-642-67714-4_6

Cited by 16 publications

(5 citation statements)

References 95 publications

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“…Reports from a Taiwanese center, and our own center showed a frequency of benign (presumably reflux-related) esophageal stricture of only 0.4% and 0.2% respectively, among patients endoscoped for various gastrointestinal indications [16,19] . These frequencies are lower in comparison with those in reports from the West [25] .…”

Section: Prevalence Of Gerd Complicationscontrasting

confidence: 76%

Gastroesophageal reflux disease is uncommon in Asia: evidence and possible explanations

Ho¹

1999

WJG

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Section: Prevalence Of Gerd Complicationscontrasting

confidence: 76%

Gastroesophageal reflux disease is uncommon in Asia: evidence and possible explanations

Ho¹

1999

WJG

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“…Evidence from previous studies regarding the influence of gender on the prevalence of GORD-like symptoms is mixed. In a review of this issue, Sonnenberg noted that some studies, but not all, have identified a male preponderance for symptoms of GORD (15). Recent studies have failed to provide a definitive answer, with some finding no gender bias (16)(17)(18)(19), and others observing a male preponderance (11,(20)(21)(22).…”

Section: Discussionmentioning

confidence: 94%

Three-Month Prevalence Rates of Gastrointestinal Symptoms and the Influence of Demographic Factors: Results from the Domestic/International Gastroenterology Surveillance Study (DIGEST)

Stanghellini

1999

Scandinavian Journal of Gastroenterology

198

140

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Stanghellini V. Three-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol 1999;34 Suppl 231:20-8.Background: This paper reports the 3-month prevalence rates of gastrointestinal (GI) symptoms from the Domestic/International Gastroenterology Surveillance Study (DIGEST), and their relationship with demographic factors; namely age, gender and body mass index (BMI). Methods: Subjects were recruited from 10 international sites by a total of 5581 face-to-face interviews conducted with randomly selected members of the general population aged 18 years and over (50.6% female; mean age 44 years). The sample was divided according to whether subjects reported 1 or more of 14 GI symptoms, or no GI symptoms. Those with any of 11 upper GI symptoms were then subdivided according to their most bothersome symptom: gastro-oesophageal reflux (GORD)-like symptoms, ulcer-like symptoms or dysmotility-like symptoms. Symptoms were classified as relevant if they were of at least moderate severity and/or occurred at least once a week. Results: A mean of 46.4% of subjects reported experiencing one or more of the 14 GI symptoms, with 28.1% experiencing upper GI symptoms classified as relevant. Significant differences between the prevalences of relevant symptoms were evident between sampling sites. The estimated prevalence of GORD-like symptoms for the pooled sample was 7.7%. For ulcer-like symptoms, prevalence was 4.1%, and for dysmotility-like symptoms 15.5%. Significant differences were observed in the prevalence rates of symptom groups between countries. Women were significantly more likely than men to experience relevant symptoms, with gender differences also observed in the rates of GORD-like and dysmotility-like symptoms. The proportion of those with relevant symptoms experiencing GORD-like symptoms increased significantly with age; ulcer-like symptoms showed no significant relationship with age; and dysmotility-like symptoms decreased significantly with age. The prevalence of relevant symptoms increased with increasing BMI. Conclusions: In conclusion, the DIGEST has provided valuable data on the cross-country prevalence of upper GI symptoms, and their association with biological factors.

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“…Gastric atrophy and reduced acid output mean a greater risk for gastric cancer, but a smaller risk for GERD and oesophageal adenocarcinoma. GERD is common in the developed countries of the Western hemisphere, but relatively uncommon in the developing countries of Asia and Africa 35 . The geographical distribution of GERD could reflect an underlying geographical distribution of H. pylori , the infection being common in developing but relatively uncommon in developed countries.…”

Section: The Role Of Helicobacter Pylori In Gerdmentioning

confidence: 99%

“…GERD is common in the developed countries of the Western hemisphere, but relatively uncommon in the developing countries of Asia and Africa. 35 The geographical distribution of GERD could reflect an underlying geographical distribution of H. pylori, the infection being common in developing but relatively uncommon in developed countries. The increased hygiene in populations of developed countries may have resulted in the recent fall in H. pylori infection and a concomitant increase in the susceptibility to the development of reflux disease.…”

Section: The Role Of Helicobacter Pylori In Gerdmentioning

confidence: 99%

Review article: trials on reflux disease — the role of acid secretion and inhibition

Sonnenberg

2004

Aliment Pharmacol Ther

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Summary The importance of gastric acid in the pathophysiology of gastro‐oesophageal reflux disease is substantiated by the extraordinary therapeutic success of acid inhibition in the management of the disease. The influence of many risk factors for gastro‐oesophageal reflux disease is also mediated through their effect on gastric acid secretion and acid reflux. Helicobacter pylori reduces the risk of gastro‐oesophageal reflux disease by causing corpus gastritis and reducing gastric acid output. The geographical and temporal trends of H. pylori infection in human populations and its influence on gastric acid secretion are responsible for much of the apparent epidemiology of gastro‐oesophageal reflux disease. On average, intra‐oesophageal exposure to acid is higher in patients who respond poorly to antisecretory medication. It also tends to increase with increasing severity of reflux disease. However, gastric acid secretion and intra‐oesophageal acid exposure vary markedly in reflux patients. The degrees of gastric or intra‐oesophageal acidity do not allow the prediction of the presence or severity of gastro‐oesophageal reflux disease in the individual subject. The many clinical trials on gastro‐oesophageal reflux disease indicate that the reflux of gastric acid constitutes an essential mechanism in the development of this disease, but that additional and partly unknown risk factors must contribute to its aetiology and promote its occurrence in the individual patient.

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Epidemiologie und Spontanverlauf der Refluxkrankheit

Cited by 16 publications

References 95 publications

Gastroesophageal reflux disease is uncommon in Asia: evidence and possible explanations

Gastroesophageal reflux disease is uncommon in Asia: evidence and possible explanations

Three-Month Prevalence Rates of Gastrointestinal Symptoms and the Influence of Demographic Factors: Results from the Domestic/International Gastroenterology Surveillance Study (DIGEST)

Review article: trials on reflux disease — the role of acid secretion and inhibition

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