Clinical observations of biofouling on PEO coated silicone hydrogel contact lenses

Broad Spectrum Antimicrobial Activity of Melimine Covalently Bound to Contact Lenses

“…29,30 Strategies that have been designed to prevent microbial colonization of contact lenses include incorporation of nonsteroidal anti-inflammatory drugs (NSAID), 31,32 phosphorylcholine, 33 fimbrolides, 34 silver, 35 selenium, 36 antimicrobial cationic peptides (AMP), 37,38 or high density poly (ethylene oxide) dialdehyde (PEO(ALD) 2 ). 39 However, disadvantages of these technologies are that NSAIDs and silver need to be released from lenses to retain activity, and so might lose activity during use; PEO(ALD) 2 and phosphorylcholine coatings are passive anti-adhesive agents (i.e., do not contain inherent antimicrobial activity). In addition, most strategies have not been tested against Acanthamoeba, fungal isolates, or drug resistant bacteria.…”

Antimicrobial and Anti‐Inflammatory Intelligent Surfaces

“…Several hydrogel coatings, for example, from PEG, 64 polyacrylamide, 16 and polylysine -PEG copolymers 14 have shown resistance to bacterial colonization. It must be noted, however, that in vivo fouling is more complex than what in vitro models can mimic at present, 63 and in vitro tests of protein and cell resistance may not directly translate to resistance to bacterial attachment in vivo . It is also of interest to note that there is a need for covalent attachment of nonfouling hydrogel polymers onto the biomaterial surface in order to achieve long -lasting resistance to bacterial settlement.…”

Surface-grafted block copolymer brushes with continuous composition gradients of poly(poly(ethylene glycol)-monomethacrylate) and poly(N-isopropylacrylamide)

“…Cells can adhere, spread, and proliferate on the thermoresponsive surface coated with PNIPAAm at 37 °C, and can be spontaneously detached from the hydrophilic surfaces formed below the LCST without enzymatic digestion [37][38][39]. On the other hand, poly(ethylene glycol) (PEG) and its derivatives have a good antifouling effect to many kinds of molecules, proteins and even cells, enabling their wide applications in the biomedical field [42][43][44][45][46][47][48]. The PEG molecules also have a faster hydration rate than the PNIPAAm, and therefore tethering the PEG molecules will speed up the release of cells cultured on the PNIPAAm surface.…”