Clinical observation on trigonella foenum-graecum L. total saponins in combination with sulfonylureas in the treatment of type 2 diabetes mellitus

Abstract

The combined therapy of TFGs with sulfonylureas hypoglycemic drug could lower the blood glucose level and ameliorate clinical symptoms in the treatment of T2DM, and the therapy was relatively safe.

Meta-analysis of the effect of herbal supplement on glycemic control in type 2 diabetes

“…• BMI ≥ 29 kg/m 2 -Trigonella foenum-graecum L. vs. placebo Gupta et al (2001) • Newly diagnosed type 2 diabetes patients • Patients with known renal and hepatic dysfunction • On lipid lowering therapy Lu et al (2008) • Type 2 diabetes patients aged 25 to 65 years old • Had previously taken SU for more than 1 year with good effectiveness at beginning, but the effect was reduced as time went on • Had taken sufficient SU at least in the last month with fast blood glucose between 7 mmol/L and 13 mmol/L for more than twice, and fluctuating within ±1.5 mmol/L with other reasons excluded -Data are mean ± SD; TC, total cholesterol; TG, triglyceride; HDL, high density lipoprotein; PPG, post prandial glucose; BW, body weight; BMI, body mass index.…”

“…Different preparations were used between the two trials of fenugreek, i.e. hydroalcoholic extract of fenugreek seed and fenugreek powder (Lu et al, 2008), thus difference in phytoconstituents. This may contribute to significant heterogeneity in the study results.…”

“…Of the nine trials, five were rated as high quality Suppapitiporn et al, 2006;Blevins et al, 2007;Hussain, 2007;Ludvik et al, 2008). However, most of them did not describe randomization method (Ludvik et al, 2004;Huseini et al, 2006;Mang et al, 2006;Suppapitiporn et al, 2006;Blevins et al, 2007;Lu et al, 2008;Ludvik et al, 2008) and did not mention whether placebo and single herb was indistinguishable (Ludvik et al, 2004;Huseini et al, 2006;Mang et al, 2006;Blevins et al, 2007;Lu et al, 2008;Ludvik et al, 2008). The latter is considerably important especially for aromatic herbs such as cinnamon and fenugreek.…”

“…Of the 23 trials, 14 were further excluded as they used totally different kinds of herb and the results were not poolable. The remaining 9 trials (n = 487) assessing the effect of Cinnamomum cassia (cinnamon) (Mang et al, 2006;Suppapitiporn et al, 2006;Blevins et al, 2007), Ipomoea batatas (sweet potato) (Ludvik et al, 2004(Ludvik et al, , 2008, Silybum marianum (milk thistle) (Huseini et al, 2006;Hussain et al, 2007) and Trigonella foenum-graecum (fenugreek) Lu et al, 2008) were included in the meta-analysis. Characteristics of the included trials are presented in Table 1 .…”

Evaluation of eco-friendly coagulant from <i>Trigonella foenum-graecum</i> seed

“…foenum-graecum (Fenugreek) belongs to the family Leguminosae that grows predominantly in Asia, Northern Africa and the Middle East. Fenugreek seed contains 23% -26% protein, 6% -7% fat and 58% carbohydrates of which 25% is dietary fiber, saponins [7] and rich in flavonoids. Fenugreek has been widely used as a flavoring agent and in folk medicine.…”