Clinical observation and treatment of leptospirosis

In Vitro Sensitivity and Resistance of 46 Leptospira Strains Isolated from Rats in the Philippines to 14 Antimicrobial Agents

“…The MIC 50 s and MIC 90 s of the strains are included in the tables. From our results, all of the strains were found to be sensitive to ampicillin, ciprofloxacin, doxycycline, erythromycin, and streptomycin, which correlates with previous studies (6,8,11,12,15,18,19). Norfloxacin, which has not been tested before for antileptospiral activity, was also found to be effective against these strains ( Table 1).…”

“…Among the tested antimicrobials, penicillins, doxycycline, and broad-spectrum cephalosporins are widely used for the treatment of leptospirosis (2,17,25). The other drugs were also found to be effective against Leptospira isolates in several in vitro (6,8,11,12,15,18,19) and in vivo (3,5,17,20,21,22) studies.…”

“…Due to these difficulties, clinically suspected cases are usually treated by empirical chemotherapy, for which information about the susceptibilities of Leptospira isolates against various antimicrobial agents is required. Several studies have been reported previously regarding the susceptibilities of Leptospira isolates to a large number of antimicrobial agents (6,8,11,12,15,18,19). However, most of these reports used laboratory-passaged strains.…”

TNF-α and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicola

“…Leptospira can enter the human body through skin wounds, including very small scratches, as well as through intact mucous membranes of the mouth, nose and eyes (7). Immune response to leptospirosis is mainly humorally mediated and involves opsonization of leptospires by macrophages and neutrophils (10).…”

Leptospirosis: Puesta al día

“…A pesar de no haberse acumulado evidencia suficiente 40 , considerando los antecedentes recopilados y en ausencia de métodos diagnósticos rápidos, específicos y sensibles, puede concluirse que los pacientes se beneficien con el tratamiento antibacteriano. Esta postura ha sido la asumida por el MINSAL de 43 y otros. Las dosis, vías de administración y duración del tratamiento recomendadas dependen de la intensidad del cuadro clínico (Tabla 4).…”