Clinical multi-functional OCT for retinal imaging

Azuma, Shinnosuke; Makita, Shuichi; Kasaragod, Deepa; Sugiyama, Satoshi; Miura, Masahiro; Yasuno, Yoshiaki

doi:10.1364/boe.10.005724

Cited by 9 publications

(5 citation statements)

References 71 publications

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“…PD detection can be achieved using bulk [67], [88] or semibulk optics [84], [85], [87] and also using polarization fiber components [83] or a combination of fiber and bulk optics [79]. In SS-OCT, the PD detector typically comprises two dual-balanced photodetectors.…”

Section: G Dynamic Oct (D-oct)mentioning

confidence: 99%

“…The retina is one of the first and most successful application targets of JM-OCT. For clinical retinal investigation, several clinical prototype devices [48], [87], including a functionlimited simplified version [85], have been developed.…”

Section: A Retinal Investigationmentioning

confidence: 99%

“…In particular, the implementations of the authors started with a bulk laboratory prototype [39], [78], [94], and a compact clinical prototype based on the identical optical setup was demonstrated [48]. By introducing semi-bulk packages of the polarization multiplexer and PD detector, a more compact and stable clinical system has been demonstrated [87]. A simplified retinal JM-OCT, which uses a PD detector but does not multiplex the input polarization, has also been demonstrated [85].…”

Section: A Retinal Investigationmentioning

confidence: 99%

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Multi-Contrast Jones-Matrix Optical Coherence Tomography—The Concept, Principle, Implementation, and Applications

Yasuno

2023

IEEE J. Select. Topics Quantum Electron.

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Jones-matrix optical coherence tomography (JM-OCT) is an extension of polarization-sensitive OCT, which provides multiple types of optical contrasts of biological and clinical samples. JM-OCT measures the spatial distribution of the Jones matrix of the sample and also its time sequence. All contrasts (i.e., multi-contrast OCT images) are then computed from the Jones matrix. The contrasts obtained from the Jones matrix include not only the conventional and polarization-insensitive OCT intensity, cumulative and local phase retardation (birefringence), degreeof-polarization uniformity quantifying the polarization randomness of the sample, diattenuation, but also signal attenuation coefficient, sample scatterer density, Doppler OCT, OCT angiography, and dynamic OCT that contrasts intracellular motility or metabolism by analyzing the temporal fluctuation of the OCT signal. JM-OCT is a generalized version of OCT because it measures the generalized form of the sample information; i.e., the Jones matrix sequence. This review summarizes the basic conception, mathematical principle, hardware implementation, signal and image processing, and biological and clinical applications of JM-OCT. Advanced technical topics, including JM-OCTspecific noise correction and quantity estimation and JM-OCT's self-calibration nature, are also described.

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Section: G Dynamic Oct (D-oct)mentioning

confidence: 99%

Section: A Retinal Investigationmentioning

confidence: 99%

Section: A Retinal Investigationmentioning

confidence: 99%

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Multi-Contrast Jones-Matrix Optical Coherence Tomography—The Concept, Principle, Implementation, and Applications

Yasuno

2023

IEEE J. Select. Topics Quantum Electron.

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“…However, pigments such as melanin that are contained in the RPE cells have the property to depolarize backscattered light while other outer retinal layers such as the photoreceptor layers are mainly polarization preserving. A differentiation between these retinal tissue properties can be performed by polarization-sensitive (PS) OCT [8,9], which represents a functional extension of the standard OCT technique and allows for a clear and selective visualization of RPE tissue [10][11][12][13][14][15][16]. In vitro studies have shown that the amount of depolarization caused by melanin depends on its concentration [17,18].…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of depolarization by the retinal pigment epithelium in healthy and glaucoma subjects measured over a large field of view

et al. 2022

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We present measurements of depolarization introduced by the retinal pigment epithelium (RPE) over a 45° field of view using polarization sensitive optical coherence tomography. A detailed spatial distribution analysis of depolarization caused by the RPE is presented in a total of 153 subjects including both healthy and diseased eyes. Age and sex related differences in the depolarizing character of the RPE are investigated.

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“…In projection images captured by polarization-sensitive OCT, RPE changes are obscured by depolarization involving choroidal melanin 25 . To overcome this limitation, we developed an automatic highlighting algorithm for RPE-melanin using multi-contrast OCT (MC-OCT) 26 , which enables simultaneous collection of OCT angiography, polarization-sensitive OCT, and standard OCT images [27][28][29] . From the MC-OCT dataset, we derived RPE-melanin-specific contrast OCT (RPE-melanin OCT) images, which we used to evaluate RPE changes 26 .…”

mentioning

confidence: 99%

Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration

Miura

Makita

Yasuno

et al. 2021

Sci Rep

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The purpose of this study was to quantitatively evaluate retinal pigment epithelium (RPE) changes in serous pigment epithelial detachment (PED) among patients with age-related macular degeneration by means of prototype multi-contrast optical coherence tomography (OCT), which is capable of simultaneous collection of OCT angiography, polarization-sensitive OCT, and standard OCT images. We evaluated 26 eyes of 21 patients with serous PED. RPE-melanin OCT images were calculated from the multi-contrast OCT dataset and compared with near-infrared autofluorescence images. An active RPE lesion was defined as an area of thickened RPE-melanin (≥ 70 μm; RPE70) on RPE-melanin OCT. Each PED area was divided into peak and slope regions. RPE70 area ratios were compared with the maximum PED height, PED area, PED volume, and slope area ratio (area of slope region/area of whole PED). RPE-melanin OCT images were consistent with near-infrared autofluorescence images. The RPE70 area ratio in the slope region was significantly negatively correlated with the slope area ratio. Development of active RPE lesions in the slope region was correlated with the PED configuration. Multi-contrast OCT is useful for objective evaluation of changes in the RPE in patients with age-related macular degeneration.

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Clinical multi-functional OCT for retinal imaging

Cited by 9 publications

References 71 publications

Multi-Contrast Jones-Matrix Optical Coherence Tomography—The Concept, Principle, Implementation, and Applications

Multi-Contrast Jones-Matrix Optical Coherence Tomography—The Concept, Principle, Implementation, and Applications

Quantitative assessment of depolarization by the retinal pigment epithelium in healthy and glaucoma subjects measured over a large field of view

Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration

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