Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration

Miura, Masahiro; Makita, Shuichi; Yasuno, Yoshiaki; Iwasaki, Takuya; Azuma, Shinnosuke; Mino, Toshihiro; Yamaguchi, Tatsuo

doi:10.1038/s41598-021-82563-z

Cited by 6 publications

(6 citation statements)

References 43 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It may also arise from the liquid under RPE. However, a high infrared uorescence signal originates from melanin and melanin lipofuscin [9][10]. Our results showed that high spontaneous uorescence in drusenoid PED represented signi cant RPE changes in PED, however, no signi cant moving and accumulation of RPE cells was observed in serous PED.…”

Section: Discussionmentioning

confidence: 58%

Multi-Mode Imaging Characteristics And Prognosis of Large Avascular Retinal Pigment Epithelium Detachment (Aped) In Macular Area

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose: To investigate multi-mode imaging characteristics for understanding the natural prognosis of large avascular retinal pigment epithelium detachment (aPED) in macular area. Methods: We retrospectively analyzed patients diagnosed with aPED at Beijing Tongren Hospital Affiliated to Capital Medical University from January 2010 to June 2021. Patients with aPED maximum diameter greater than 1500 μm underwent best-corrected visual acuity (BCVA), fundus color photography, spontaneous fluorescence, infrared photography, FFA, ICGA, and OCT tests. Based on aPED characteristics, patients were divided into serous or drusenoid PED. In addition, the imaging characteristics for different types of large aPED were explored for its natural diagnosis.Results: A total of 64 eyes of 50 cases with large aPED were recruited. 21 males and 29 females with an average age of 64.31±6.38 years. The recruited population included 14 cases with the binocular disease, whereas 13 and 51 eyes had serous and drusenoid PED, respectively. Eight eyes (61.54%) of serous PED patients had drusen. Drusenoid PED patients had drusen in 47 eyes (92.17%). The OCT of serous PED patients showed large PED with uniform low reflection and RPE hyperplasmia (n=2 eyes). In contrast, the OCT of drusenoid PED patients showed some uneven, slightly high, or high reflection and RPE hyperplasmia in all the eyes. In addition, 46 eyes were accompanied by the subretinal fluid (SRF) (90.20%), 28 eyes developed hyperreflective foci between retinal layers (54.90%), and 3 eyes had inner retinal capsules (5.88%). No abnormal blood flow signal was detected in OCTA. The independent t-test showed no significant differences in the general conditions between the two groups, including age, BCVA, PED bottom diameter, and PED height. A total of 19 eyes of 16 cases were followed up, with an average follow-up time of 21.56 ± 18.85 months. Out of these 19 eyes, 12 eyes developed enlarged PED bottom diameter (63.16%), 5 eyes had partial or entire geographic atrophy (26.32%), 1 eye had RPE laceration (5.26%) and 1 eye had no changes (5.26%). However, no case developed into vascular PED (vPED).Conclusions: Multi-mode imaging provided imaging events, contributing to a more accurate diagnosis of aPED. Different types of aPED might be the different stages of same disease, need close observation, however, the natural course of disease shifted to geographic atrophy.Trial registration: Retrospective case series study, not applicable.

show abstract

Section: Discussionmentioning

confidence: 58%

Multi-Mode Imaging Characteristics And Prognosis of Large Avascular Retinal Pigment Epithelium Detachment (Aped) In Macular Area

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…The retinal pigment exhibits strong depolarization [55] and low DOPU [44], [55], [56]. The DOPU has therefore been used to visualize the retinal pigment epithelium and its abnormality [57]- [60].…”

Section: Dopumentioning

confidence: 99%

“…Early studies targeted the quantification of retinal nerve fiber layers [77], [79], [94] as a biomarker of glaucoma. After PS-OCT studies showed that retinal pigments exhibit low DOPU [44], JM-OCT was also adopted to investigate the retinal pigment epithelium (RPE) [58]- [60], [77], [95] and choroidal melanin [95]- [98] through DOPU imaging. The former application was found to be useful in the investigation of exudative retinal diseases, such as age-related macular degeneration [46], [60], [99], whereas the latter was found to be useful in the staging of Vogt-Koyanagi-Harada disease [96], [97].…”

Section: A Retinal Investigationmentioning

confidence: 99%

Multi-Contrast Jones-Matrix Optical Coherence Tomography—The Concept, Principle, Implementation, and Applications

Yasuno

2023

IEEE J. Select. Topics Quantum Electron.

View full text Add to dashboard Cite

Jones-matrix optical coherence tomography (JM-OCT) is an extension of polarization-sensitive OCT, which provides multiple types of optical contrasts of biological and clinical samples. JM-OCT measures the spatial distribution of the Jones matrix of the sample and also its time sequence. All contrasts (i.e., multi-contrast OCT images) are then computed from the Jones matrix. The contrasts obtained from the Jones matrix include not only the conventional and polarization-insensitive OCT intensity, cumulative and local phase retardation (birefringence), degreeof-polarization uniformity quantifying the polarization randomness of the sample, diattenuation, but also signal attenuation coefficient, sample scatterer density, Doppler OCT, OCT angiography, and dynamic OCT that contrasts intracellular motility or metabolism by analyzing the temporal fluctuation of the OCT signal. JM-OCT is a generalized version of OCT because it measures the generalized form of the sample information; i.e., the Jones matrix sequence. This review summarizes the basic conception, mathematical principle, hardware implementation, signal and image processing, and biological and clinical applications of JM-OCT. Advanced technical topics, including JM-OCTspecific noise correction and quantity estimation and JM-OCT's self-calibration nature, are also described.

show abstract

“…Die Kombination der NIA mit Adaptive Optics unterstützt sowohl die Darstellung von Zapfen als auch RPE-Zellen 36 . Mit dem Prototyp einer neuen Technik (Multicontrast optical Coherence Tomography) mit einer Kombination verschiedener OCT-Verfahren einschließlich einem polarisationsspezifischen OCT kann die Melanin-Verteilung im RPE vergleichbar zur NIA dargestellt werden 37 .…”

Section: Ausblick In Die Zukunftunclassified

“…Die Relevanz der NIA für die Darstellung pathologischer Veränderungen des Melanin-Stoffwechsels als Biomarker chorioretinaler Erkrankungen im Langzeitverlauf muss noch weiter evaluiert werden.Die Kombination der NIA mit Adaptive Optics unterstützt sowohl die Darstellung von Zapfen als auch RPE-Zellen[36]. Mit dem Prototyp einer neuen Technik (Multicontrast optical Coherence Tomography) mit einer Kombination verschiedener OCT-Verfahren einschließlich einem polarisationsspezifischen OCT kann die Melanin-Verteilung im RPE vergleichbar zur NIA dargestellt werden[37].KERNAUSSAGEN ▪ Die Nahinfrarot-Autofluoreszenz (NIA) ist eine nichtinvasive Untersuchungstechnik, welche auf den fluorophoren Eigenschaften des Melanins in den RPE-Zellen basiert und dadurch Veränderungen des Melanin-Gehalts im retinalen Pigmentepithel (RPE) darstellen kann. ▪ Die NIA ist eine für den Patienten wenig belastende retinale Bildgebung und kann daher auch bei Kindern oder stark blendungsempfindlichen Personen gut durchgeführt werden.…”

unclassified

Nahinfrarot-Autofluoreszenz: klinische Anwendung und diagnostische Relevanz

Kellner¹,

Weinitz²,

Farmand³

et al. 2022

Augenheilkunde up2date

View full text Add to dashboard Cite

ZusammenfassungDie Nahinfrarot-Autofluoreszenz (NIA) ist ein nicht-invasives Verfahren zur Untersuchung des retinalen Pigmentepithels (RPE) basierend auf der Darstellung des antioxidativen Schutzfaktors Melanin in den RPE-Zellen. Die NIA verbessert die Früherkennung chorioretinaler Erkrankungen, da bei vielen dieser Erkrankungen mit der NIA Strukturveränderungen des RPE nachweisbar sind, bevor sich in anderen Untersuchungen Krankheitszeichen erkennen lassen.

show abstract

Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment in age-related macular degeneration

Cited by 6 publications

References 43 publications

Multi-Mode Imaging Characteristics And Prognosis of Large Avascular Retinal Pigment Epithelium Detachment (Aped) In Macular Area

Multi-Mode Imaging Characteristics And Prognosis of Large Avascular Retinal Pigment Epithelium Detachment (Aped) In Macular Area

Multi-Contrast Jones-Matrix Optical Coherence Tomography—The Concept, Principle, Implementation, and Applications

Nahinfrarot-Autofluoreszenz: klinische Anwendung und diagnostische Relevanz

Contact Info

Product

Resources

About