Clinical, morphological, CT and MRI characteristics of anterior skull base and orbital tumors

Palamar, Orest I.; Lukach, Erwin V.; Maletskyi, A. P.; Poliakova, S. I.; Kravets, O. V.; Serezhko, Yu. O.; Okonskyi, Dmytro I.

doi:10.31288/oftalmolzh202056274

Cited by 2 publications

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“…Tooth germ malposition and crowding or lack of tooth germs have been observed in the disease. This may cause abnormality of eruption timing, partial anodontia, and incomplete retention of erupted permanent teeth [16,17]. Some authors believe that the treatment of cherubism should include opening cystic cavities and cleaning them thoroughly [18,19].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic assessment and treatment of cherubism as prevention of ocular complications

Nazaryan¹,

Mikhailenko²,

Yaroslavska³

et al. 2022

Oftalmol Zh

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This is an initiative study. Cherubism as a form of fibrous dysplasia of jaw bones is a congenital hereditary abnormality of osseous tissue maturation. Although the disease requires mostly maxillofacial surgery and orthodontic care, patients also have to be consulted by an ophthalmologist. The purpose of this study was to share our experience in the diagnostic assessment and treatment of cherubism, a rare form of fibrous dysplasia that is commonly misdiagnosed, which results in inadequate treatment and may lead to serious ocular complications. We present our experience of diagnostic assessment and treatment of four patients with cherubism for one to twenty years. The diagnosis of cherubism became evident after histological study of the material excised during surgery, because postoperative histology showed that changes were not cancerous (adamantinoma), but dysplastic. In addition, new foci developed or old foci recurred some time after surgery. Consequently, true jaw tumors must be correctly differentiated from dental cysts and from dysplastic bone lesions. Patients were followed up once every 6 months. Over the period of follow-up, ocular involvement was observed in the woman who had been diagnosed in childhood with congenital mixed astigmatism. Given our observations, one may make a conclusion that cherubism, a rare form of fibrous dysplasia, is a hereditary or familial disorder, and regresses after completion of puberty and puberty-related changes in hormonal milieu. Timely orthodontic care (and, if required, maxillofacial surgery care) will facilitate preventing the progression of the disease and its ophthalmological consequences. Special attention of ophthalmologists should be paid to cherubism patients with maxillary lesions.

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Section: Discussionmentioning

confidence: 99%

Diagnostic assessment and treatment of cherubism as prevention of ocular complications

Nazaryan¹,

Mikhailenko²,

Yaroslavska³

et al. 2022

Oftalmol Zh

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“…Malignant tumors of the orbit represents the main cause for 41-45.9% of orbital tumors [1,2] and they will threaten both the organ of vision and the life of the patient. According to some authors [2], recurrence of malignant tumors of the orbit within 5 years was observed in 36 of the 56 patients who were observed and recurrence of the tumor was observed in 64.3% of patients who died in subsequent years.…”

Section: Introductionmentioning

confidence: 99%

Improving the Antitumor Effect of Doxorubicin in the Treatment of Eyeball and Orbital Tumors

Parfentievich¹,

Markovich²,

Mikhailivna³

2021

Advances in Precision Medicine Oncology

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Malignant tumors of the orbit are the main cause for 41–45.9% of orbital tumor, and they will threaten both the organ of vision and the life of the patient. In our opinion, improving the effectiveness of treatment of malignant tumors can be implemented in the following areas: a) immobilization of doxorubicin in synthetic polymeric materials, which will fill the tissue structures that were resected and reduce the percentage of tumor recurrence. b) the use of nanomaterials for the delivery of doxorubicin to tumor cells. To develop a hydrogel implant and nanoparticles, to study the diffusion kinetics of doxorubicin in a hydrogel implant and the ability of nanoparticles to transport doxorubicin. The developed gels based on acrylic acid (AAc) were obtained by radical polymerization of an aqueous solution of monomers (AAc and N, N-methylenebisacrylamide (MBA)) at a temperature of 70°C. Matrices based on polyvinyl formal (PVF) were obtained by treatment of polyvinyl alcohol (PVA) with formaldehyde in the presence of a strong acid. Experimental studies were performed on rabbits of the Chinchilla breed, weighing 2–3 kg, aged 5–6 months, which during the study were in the same conditions. We implanted the hybrid gel in the scleral sac; orbital tissue and in the ear tissue of rabbits: Evaluation of the response of soft tissues and bone structures to implant materials was carried out on the basis of analysis of changes in clinical and pathomorphological parameters was performed after 10, 30 and 60 days. Diffusion of doxorubicin was examined by using UV spectroscopy [spectrophotometer-fluorimeter DS-11 FX + (DeNovix, USA)], analyzing samples at regular intervals during the day at a temperature of 25° C. The concentration of active substances was determined by the normalized peak absorption of doxorubicin at 480 nm. The release kinetics of the antitumor drug doxorubicin were investigated by using a UV spectrometer “Specord M 40” (maximum absorption 480 nm). The developed hydrogel implant has good biocompatibility and germination of surrounding tissues in the structure of the implant, as well as the formation of a massive fibrous capsule around it. An important advantage of the implant is also the lack of its tendency to resorption. Moreover, the results showed that the diffusion kinetics of doxorubicin from a liquid-crosslinked hydrogel reaches a minimum therapeutic level within a few minutes, while in the case of a tightly crosslinked - after a few hours. It was also found that the liquid-crosslinked hydrogel adsorbs twice as much as the cytostatic - doxorubicin. The analysis of the research results approved that the size of the nanoparticles is the main factor for improving drug delevary and penetration. Thus, nanoparticles with a diameter of less than 200 nm can penetrate into cells and are not removed from the circulatory system by macrophages, thereby prolonging their circulation in the body. About 10 nm. The developed hybrid hydrogel compositions have high mechanical strength, porosity, which provides 100% penetration of doxorubicin into experimental animal tissues. It was found that the kinetics of diffusion of drugs from liquid-crosslinked hydrogel reaches a minimum therapeutic level within a few minutes, whereas in the case of densely crosslinked hydrogel diffusion begins with a delay of several hours and the amount of drug released at equilibrium reaches much lower values (20–25%). The obtained preliminary experimental results allow us to conclude that our developed pathways for the delivery of drugs, in particular, doxorubicin to tumor cells will increase the effectiveness of antitumor therapy.

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Clinical, morphological, CT and MRI characteristics of anterior skull base and orbital tumors

Cited by 2 publications

References 0 publications

Diagnostic assessment and treatment of cherubism as prevention of ocular complications

Diagnostic assessment and treatment of cherubism as prevention of ocular complications

Improving the Antitumor Effect of Doxorubicin in the Treatment of Eyeball and Orbital Tumors

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