Clinical markers and some trace elements in patients with type-2 diabetic nephropathy : Impact of insulin resistance

Al–Fartosy, Adnan J. M.; Awad, Nadhum A.N.; Alsalimi, Sadoun Abbas

doi:10.2152/jmi.68.76

Cited by 4 publications

(8 citation statements)

References 41 publications

(40 reference statements)

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“…Zn can operate as an antioxidant by shielding the sulfhydryl groups of various proteins and enzymes from free radicals and reducing oxidative stress. In contrast, copper is regarded as a pro-oxidant and oxidant metal in physio-chemistry 23 . One of the trace elements necessary for adequate insulin hormone response is zinc.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the clinical significance of RBP4, PAI-1, and some trace elements in women with Polycystic Ovary Syndrome

Al–Fartosy

Awad

Mohammed

2023

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To assess and compare clinical, hormonal, and metabolic factors with blood levels of RBP4, PAI-1, and trace elements in women with and without polycystic ovarian syndrome (PCOS). A cross-sectional clinical investigation was undertaken. From December 2020 until January 2022, samples were taken at the Basrah Hospital for Obstetrics and Children's infertility center. Significant changes (p< 0.05) were in HOMA-IR, E2 and Ts. Levels of PAI-1, RBP4, AMH, LH, LH/FSH, PRL and Cu were significantly (p<0.01) increased, and levels of Se, Zn, Mg and E2/T were significantly (p<0.01) decreased, between the patient (1o PCOS and 2o PCOS) and control groups, the QUICKI level did not differ significantly (p>0.05). Compared to the control group, FSH levels were especially (p<0.05) higher in non-obese PCOS patients and lower in obese PCOS patients. Area under the receiver operating characteristics (ROC) curve (AUC) results indicate RBP4 and PAI-1 may be more effective predictors biomarkers for PCOS in expectant women. While trace elements might be considered a protective factor in the emergence of PCOS, metabolic abnormalities and IR in PCOS-affected individuals are associated with the levels of RBP4 and PAI-1, which appear to be a more acceptable diagnostic marker in the early prediction of PCOS. Keywords: Polycystic Ovary Syndrome, RBP4, PAI-1, Trace elements.

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Section: Discussionmentioning

confidence: 99%

Evaluating the clinical significance of RBP4, PAI-1, and some trace elements in women with Polycystic Ovary Syndrome

Al–Fartosy

Awad

Mohammed

2023

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“…Previous studies have found that residing in a depressed environment is linked to GDM. (17,18) Increased level of insulin resistance could be result from reduce in sensitivity of insulin which may generally found through pregnancy to spare the glucose for the fetus. Hence, this is credited to the effects of hormones secret from placenta, the physiological changes in a some women throughout pregnancy outcome in glucose tolerance damage which might lead to GDM.…”

Section: Discussionmentioning

confidence: 99%

“…The following procedures were used to analyzed blood samples for biochemical parameters: BMI was calculated as the following formula [BMI (kg/m 2 ) = Wt in kg/Ht in m2]. (15) HbA1c measurements were determined using the Bio-Rad D-10® HPLC analyzer (Bio-Rad Laboratories, Hercules, CA, USA). Serum glucose was assayed on UV-Vis Spectrophotometer (UV-EMC-LAB, Duisburg, Germany) by using the kit (Cat No.…”

Section: Biochemical Quantificationmentioning

confidence: 99%

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Insulin Resistance and Other Adipokines as Clinical Predictors of Gestational Diabetes Mellitus among Pregnant Women

Abdualhay

Al–Fartosy

2022

Indones Biomed J

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BACKGROUND: Gestational diabetes mellitus (GDM) has a strong relationship with an increased risk of maternal and perinatal complications. However, in Basrah, Iraq, studies regarding GDM are still limited. In current study, we aimed to investigate the association between insulin resistance and some clinical predictors of GDM among pregnant women in 1st and 3rd trimesters of gestation.METHODS: This case-control study was conducted on 44 pregnant women with GDM and 45 without GDM aged 20 to 40 years who applied for GDM screening during the first (9-13 week) and third trimester (24-28 week) of pregnancy. Demographics, blood glucose, HbA1c, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), spexin, nesfatin-1, orexin-A, vaspin and lipid profile levels were compared between groups.RESULTS: Subjects with GDM showed a higher level of glucose, insulin HOMA-IR, HbA1c, spexin, vaspin in the first and third trimesters of pregnancy (p<0.01) compared to the healthy subjects. Meanwhile in the first and third trimester, subjects with GDM showed significantly lower level of nesfatin-1 and orexin-A compare to the control. In third trimester, oral glucose tolerance test (OGTT) outcomes for fasting glucose at 1 hour, 2 hours, and 3 hours after glucose load were significantly higher (p<0.01). According to the area under the receiver operating characteristics (ROC) curve (AUC) findings, HOMA-IR, spexin, and vaspin may be more effective predictors biomarkers for GDM in pregnant subjects, while orexin-A and nesfatin-1 were ineffective.CONCLUSION: The correlation of insulin resistance and adipokines in the first and thrid trimester was not significantly different, which may cast new light on the possible role as an etiological cause of GDM and might be a better monitoring parameter in women with GDM. KEYWORDS: gestational diabetes mellitus, insulin resistance, vaspin, spexin, orexin-A, nesfatin-1

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“…Body Mass index (BMI) is evaluated using electronic balance and height equipment for weight and height. To calculate the body mass index, the following formula was utilized (15). where gender is substituted by 0 for males and 1 for females (16).…”

Section: Measurement Biochemical Parametersmentioning

confidence: 99%

Evaluation of serum leptin levels in hypertensive men in Thi Qar City-Iraq (a comparative study)

2023

JPTCP

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Leptin, a hormone secreted from adipose tissue, is closely related to inflammatory, metabolic, and homeostasis factors. This hormone has also been shown to perform a significant involvement in the development of hypertension. This study aimed to measure serum leptin levels and lipid profiles in hypertensive males and compare them with control healthy males that were congruent with age and BMI. The current study included 50 subjects from Thi Qar city people, and it was divided into two groups. The first group included 25 hypertensive adult male patients who had BMI (Mean±SD 27.98±2.9), while the second group included 25 healthy adults males as a control group who had BMI (Mean±SD 27.41±3.5). The current study included evaluating serum leptin and lipid profile of studied groups after 8-12 hours of fasting state. It was found that the level of leptin was high significant variance in hypertensive adults males compared to the healthy control group (22.4±3.4ng/ml against 13.9±1.6 ng/ml, respectively; p<0.03), A good correlation was also found between leptin levels and systolic, diastolic blood pressure, and body fat percentage ( r=0. 648, r=0.506, and r=0.490, respectively). It was also found that moreover male patients had a bad Lipid profile when compared to the healthy control group.

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Clinical markers and some trace elements in patients with type-2 diabetic nephropathy : Impact of insulin resistance

Cited by 4 publications

References 41 publications

Evaluating the clinical significance of RBP4, PAI-1, and some trace elements in women with Polycystic Ovary Syndrome

Evaluating the clinical significance of RBP4, PAI-1, and some trace elements in women with Polycystic Ovary Syndrome

Insulin Resistance and Other Adipokines as Clinical Predictors of Gestational Diabetes Mellitus among Pregnant Women

Evaluation of serum leptin levels in hypertensive men in Thi Qar City-Iraq (a comparative study)

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