Clinical Manifestations of Toxoplasmosis in the Adult

Theologides, Athanasios

doi:10.1001/archinte.1966.03870100064012

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1968

1993

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Cited by 13 publications

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Toxoplasmosis complicating malignancy. Experience at the national cancer institute

Vietzke

Gelderman

Grimley

et al. 1968

Cancer

153

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Severe, often fatal, infection with Toxoplasma gondii, which manifests an unusual predilection for the central nervous system, has been studied in six patients with malignancy at the National Cancer Institute. Fourteen other instances of toxoplasmosis associated with malignancy have been collected from the literature. Prominent clinical findings are those mimicking encephalitis or a mass lesion. Associated fever, rash, myocarditis and pneumonitis are also described. The major pathologic lesion is a necrotizing encephalitis of the gray matter. A striking coincidence of DNA virus infection occurred in several cases. Clinical, laboratory and pathologic details are reviewed and possible pathogenetic mechanisms are discussed. Attention is drawn to the need for increased clinical awareness of this parasitic complication of malignancy, as it may be treatable.

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