Clinical Manifestations of Coxsackievirus A6 Infection Associated with a Major Outbreak of Hand, Foot, and Mouth Disease in Japan

Kobayashi, Mariko; Makino, Tomohiko; Hanaoka, Nozomu; Shimizu, Hiroyuki; Enomoto, Mika; Okabe, Nobuhiko; Kanou, Kazuhiko; Konagaya, Masami; Oishi, Kazunori; Fujimoto, Tsuguto

doi:10.7883/yoken.66.260

Cited by 29 publications

(26 citation statements)

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“…Differential diagnosis of HFMD from chickenpox is occasionally challenging because of its unusual clinical characteristics. For example, the spread of rashes in CV-A6-HFMD is more toward the extremities and body trunk, a manner different from that in typical HFMD in which the rashes are mostly localized to the hands and soles of the feet (1,2).…”

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confidence: 89%

“…The cutaneous manifestations of CV-A6-associated HFMD (CV-A6-HFMD) are more extensive and variable than those of classic HFMD (1)(2)(3). Differential diagnosis of HFMD from chickenpox is occasionally challenging because of its unusual clinical characteristics.…”

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confidence: 99%

“…Primer pairs were designed to amplify the VP1 (partial) to VP2 (partial) coding region of CV-A6 (AB678778) and used for sensitive detection of the viral genome. We used specific primers for CV-A6 because the clinical picture was similar to the unique clinical characteristics of the CV-A6-HFMD outbreak in 2011 (2). The primers used were Ca6seq1_5 (5?-AAATGCAGTGGAAAGTGCTGTGAGC-3?)…”

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confidence: 99%

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A Case of Atypical Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6: Differential Diagnosis from Varicella in a Pediatric Intensive Care Unit

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A Case of Atypical Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6: Differential Diagnosis from Varicella in a Pediatric Intensive Care Unit

et al. 2013

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“…'nın 8 bir çalışmasında, 127 hastanın sadece 1'inde onikomadezis tespit etmiştir 7,9 . Yurtdışından yapılan çalışmalarda 21 Liu et al 14 Ooi et al 20 Solunum sayısı >26/dk Kostipasyon Yaş <2 yıl ise, tırnak tutulumu %37,6-46,6 arasında değişen oranlarda bildirilmektedir 13,28 . Hastalarımızın 10'unda (%25,6) onikomadezis ve/veya Beau's çizgileri görüldü.…”

Section: Gereç Ve Yöntemunclassified

Joint diagnosis of pediatric and dermatology clinics: Prospective observation of thirtynine patients with hand, foot and mouth disease

Bucak¹,

Tepe²,

Almış³

et al. 2017

TURKDERM

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Background and Design: Hand, foot and mouth disease (HFMD) is a childhood enteroviral eruptive disease presenting with fever and cutaneous and mucosal lesions. It is benign and generally resolves spontaneously, but may sometimes result in systemic involvement. The purpose of this study was to share our clinical experience concerning patients who were followed with the diagnosis of HFMD established by the pediatric and dermatology clinics. Materials and Methods: We prospectively evaluated patients who attended our hospital with the complaints of fever and eruptions and received the diagnosis of HFMD based on the clinical findings between December 2014 and November 2015. Age, sex, month of presentation, presentation symptoms and duration of symptoms were investigated. Systemic and dermatological examination findings, laboratory results and tests such as echocardiography were reviewed. Results: Thirty-nine patients were included; 19 (48.8%) were girl and 20 (51.2%) were boy. The mean age of the patients was 29.8±27.9 (6-155) months. Six (15.3%) patients were in the 0-12 month age group, while only 3 (7.8%) were older than 60 months. Presentations were most common in September, June and October. The most common presentation symptoms were eruptions on the hands and feet (100%), fever (82.1%) and oral aphthae (79.5%). The lesions were most commonly observed on the hands (94.9%, n=37) and feet (87.2%, n=34) and in the mouth (79.5%, n=31). Cardiac involvement was determined in 3 (7.7%) patients. Nail changes were observed during monitoring in 10 (25.6%) patients. AbstractAmaç: El-ayak-ağız hastalığı (EAAH); ateş, deri ve mukoza lezyonları ile seyreden, çocukluk çağının enteroviral döküntülü bir hastalığıdır. İyi seyirli ve kendiliğinden düzelme eğiliminde olmakla birlikte, nadiren sistemik tutuluma yol açabilir. Bu çalışmanın amacı, pediatri ve dermatoloji klinikleri tarafından EAAH tanısıyla takip edilen hastalara ait klinik deneyimlerimizi paylaşmaktır. Gereç ve Yöntem: Hastanemize Aralık 2014-Kasım 2015 tarihleri arasında ateş ve döküntü şikayeti ile başvuran hastalardan, klinik bulgulara dayanılarak EAAH tanısı koyulan hastalar prospektif olarak değerlendirildi. Hastaların yaşı, cinsiyeti, başvuru ayı, başvuru şikayeti ve süresi sorgulandı. Sistemik ve dermatolojik muayene bulguları, laboratuvar sonuçları, ekokardiyografi gibi ek inceleme tetkikleri gözden geçirildi. Bulgular: Çalışmaya toplam 39 hasta dahil edildi. Hastaların 19'u (%48,8) kız, 20'si (%51,2) erkek idi. Hastaların ortalama yaşı 29,8±27,9 (6-155) ay olarak hesaplandı. Yaş aralığına göre hastaların 6'sı (%15,3) 0-12 ay arasında iken, sadece 3'ü (%7,8) 60 aydan büyüktü. Başvurular en sık Eylül, Haziran ve Ekim aylarında görüldü. En sık başvuru şikayeti; el ve ayaklarda döküntü (%100), ateş (%82,1) ve oral aft (%79,5) idi. Lezyonlar, en sık el (%94,9, n=37), ayak (%87,2, n=34) ve ağız içinde (%79,5, n=31) görüldü. Üç hastada (%7,7) kardiyak tutulum saptandı. Takiplerde 10 hastada (%25,6) tırnak değişikliği gelişti. Sonuç: Çalışmamız sonucunda ülkemizde E...

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“…In our study, only 3 patients were 10 months old and 39.13% of the patients were 3 years or younger. Kobayashi et al has reported cases between 9 months and 9 years of age, with the majority of the cases (75%) during the first 3 years of age [12]. Mirand et al observed in their study that HFMD was more common in male patients [13].…”

Section: Discussionmentioning

confidence: 91%

Clinical and Demographic Properties of Hand-Foot and Mouth Disease

Yorulmaz¹,

Onat²

2017

Ann Clin Anal Med

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ÖzetAmaç: El-ayak-ağız hastalığı (EAAH), enterovirüs ailesinin deri ve mukozada lezyonlar oluşturduğu, çoğunlukla komplikasyonsuz seyreden sistemik bir en- Anahtar KelimelerEl-Ayak-Ağız Hastalığı; Mevsimsel Değişim; Döküntü Abstract Aim: Hand-Foot-and-Mouth Disease (HFMD), which is caused by agents of the enterovirus family, leads to skin and mucosa lesions as well as non-complicated systemic infection. In the present review, we aimed to determine clinical characteristics and seasonal distribution of the patients diagnosed with HFMD. Material and Method: The patients referred and diagnosed with HFMD through dermatological and physical examinations between April, 1, 2014 and May, 31, 2016 were reviewed in terms of demographic data, complaints and physical findings. The statistical analysis was performed by "SPSS for Windows 13", descriptive analysis was performed, and minimum-maximum values and standard deviations were calculated. The Mann Whitney U test was used. Values of p<0.05 were accepted as statistically significant. Results: Ninety two patients who were referred to top pediatrics and dermatology departments were diagnosed with HFMD. The mean age of the patients was 5.08 years (10 months-16 years). Fifty seven patients were male (61.90%), and 35 patients were female (38.10%). The most common symptoms at referral were rash (100%) and mild fever (72.82%). Rashes were found on the hands and feet (100% of patients), on the oral mucosa (92.39%), and in the gluteal region (56.52%). The disease appeared most commonly during summer and autumn. Discussion: Hand-Foot-and-Mouth Disease is a viral disease that appears most often in children of 5 years of age and younger. Clinical findings are sufficient for the diagnosis and symptomatic treatment is adequate for the cases without severe involvement. The disease is common during the summer but recently, due to seasonal variations, it has also become apparent during autumn, as well. It is important to inform the patients and their relatives about routes of transmission and the isolation methods required.

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Clinical Manifestations of Coxsackievirus A6 Infection Associated with a Major Outbreak of Hand, Foot, and Mouth Disease in Japan

Cited by 29 publications

References 3 publications

A Case of Atypical Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6: Differential Diagnosis from Varicella in a Pediatric Intensive Care Unit

A Case of Atypical Hand-Foot-and-Mouth Disease Caused by Coxsackievirus A6: Differential Diagnosis from Varicella in a Pediatric Intensive Care Unit

Joint diagnosis of pediatric and dermatology clinics: Prospective observation of thirtynine patients with hand, foot and mouth disease

Clinical and Demographic Properties of Hand-Foot and Mouth Disease

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