Clinical manifestations of co-infection with malaria and leptospirosis

Gurjar, Mohan; Saigal, Saurabh; Baronia, Arvind Kumar; Azim, Afzal; Poddar, Banani; Singh, Rajni

doi:10.1258/td.2011.110082

Cited by 9 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other LEP coinfection cases have been documented [21] and have even been associated with severe sepsis [46]. We found an association between LEP coinfection with aminotransferases elevation and thrombocytopenia previously described [47,48]. In Latin America, LEP/malaria coinfections are rarely reported, but high clinical suspicion must prevail since a late diagnosis could increase morbidity and mortality.…”

Section: Discussionsupporting

confidence: 63%

High Prevalence of viral and bacterial coinfections in malaria in Venezuela

Forero‐Peña¹,

Mora²,

Rodríguez

et al. 2021

Preprint

View full text Add to dashboard Cite

Background Malaria remains a significant public health problem worldwide. Simultaneous infections with other pathogens complicate its diagnosis and can also change the clinical course of the disease. The similarities in the clinical presentation of malaria and other infections and the superimposed endemicity result in underdiagnosis of coinfections and increase mortality. No studies have focused on the presence of coinfections in patients with malaria in Venezuela. Methods Between June and November 2018, we conducted a cross-sectional study in patients with malaria who presented to any of the three reference medical centers in Ciudad Bolívar, Venezuela. A clinical and laboratory evaluation searching for coinfections with Dengue (DENV), Chikungunya (CHIKV), Viral Hepatitis (VH) (A, B, and C), and Leptospirosis (LEP) was performed using ELISA to test each patient. Results We studied a total of 161 patients of whom 106 (65.8%) presented P. vivax infection, 43 (26.7%) P. falciparum, and 12 (7.5%) had mixed malaria infections. Coinfections were found in 55/161 (34.2%) patients and were more frequent in patients with P. falciparum (48.8%) than in those with P. vivax (29.2%), or mixed infection (25%) [OR = 2.43; 95% CI = 1.39–4.25; p = 0.018]. The most prevalent coinfection was with DENV (14.9%), followed by HAV (11.8%), HBV (6.2%), CHIKV (5.5%), and LEP (3.7%). Coinfection with HCV was absent. Complicated malaria was significantly more frequent in coinfected individuals (56.4%) than those without coinfection (35.8%) [OR: 2.31; 95% CI = 1.18–4.92; p = 0.013]. Conclusion We found a high prevalence of coinfections in patients with malaria in this region, which was related to a worse outcome. Further prospective studies with samples at different points of infection and the use of molecular tools are needed.

show abstract

Section: Discussionsupporting

confidence: 63%

High Prevalence of viral and bacterial coinfections in malaria in Venezuela

Forero‐Peña¹,

Mora²,

Rodríguez

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, aqueous crude extract of M. oleifera leaves was safe and good candidate for further studies. Liver injury in malaria patients has been reported by clinical cases [16]. From our results, liver injury in mice infected with P. berghei was shown on Day 4 after infection as indicated by increasing of AST and ALT, as well as decreasing of albumin levels.…”

Section: Discussionsupporting

confidence: 61%

The protective effect of Moringa oleifera leaf extract on liver damage in mice infected with Plasmodium berghei ANKA

2016

J Coast Life Med

View full text Add to dashboard Cite

“…The diagnosis of acute leptospirosis is even more complicated when the patients are from endemic areas of other infectious diseases where there are increasing number of reports for co-infection/co-incidence of leptospirosis with other endemic infectious diseases, e.g. dengue virus infection 8, 15–17, 19, 20 , malaria 40–44 , and melioidosis 13 .…”

Section: Discussionmentioning

confidence: 99%

Development and evaluation of an immunochromatographic assay to detect serum anti-leptospiral lipopolysaccharide IgM in acute leptospirosis

Doungchawee

Sutdan²,

Niwatayakul

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Leptospirosis is a common life-threatening disease worldwide. However, its diagnosis is frequently ineffective because the gold standard bacterial culture and microscopic agglutination test (MAT) are usually positive 1–2 weeks after the disease onset. We thus developed an immunochromatographic assay (LEPkit) to detect serum anti-leptospiral lipopolysaccharide (LPS) IgM for rapid diagnosis of acute leptospirosis. Using referenced sera of 77 leptospirosis and 91 non-leptospirosis cases, LEPkit yielded 97.4% sensitivity, 94.5% specificity, 93.8 positive predictive value (PPV), 97.7% negative predictive value (NPV), and 95.8% accuracy. The stability of this kit stored for up to 18 months and its reproducibility were confirmed. Testing in 74 new cases using samples at admission-phase and subsequent paired samples (total n = 135), overall sensitivity was 98.5%, whereas that of culture and single MAT (≥1:400) was 15.6% and 35.6%, respectively. When only the samples at admission-phase were used (n = 74), the sensitivity remained at 98.7%, whereas that of culture and single MAT (≥1:400) was 28.4% and 13.5%, respectively. In summary, our LEPkit was far more effective than any conventional methods for the diagnosis of acute leptospirosis, especially within the first few days after the disease onset. The ease of use, stability and reproducibility further enhance its feasibility for clinical use on-site.

show abstract

Clinical manifestations of co-infection with malaria and leptospirosis

Cited by 9 publications

References 5 publications

High Prevalence of viral and bacterial coinfections in malaria in Venezuela

High Prevalence of viral and bacterial coinfections in malaria in Venezuela

The protective effect of Moringa oleifera leaf extract on liver damage in mice infected with Plasmodium berghei ANKA

Development and evaluation of an immunochromatographic assay to detect serum anti-leptospiral lipopolysaccharide IgM in acute leptospirosis

Contact Info

Product

Resources

About