Clinical management of squamous cell carcinoma associated with sinonasal inverted papilloma

Yasumatsu, Ryuji; Nakashima, Torahiko; Sato, Masanobu; Nakano, Tomoko; Kogo, Ryunosuke; Hashimoto, Kazuki; Sawatsubashi, Motohiro; Nakagawa, Takashi

doi:10.1016/j.anl.2016.04.004

Cited by 28 publications

(35 citation statements)

References 22 publications

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“…3 The establishment of accurate tumor markers can greatly aid clinicians in the management of tumors, including sinonasal inverted papilloma and SCC. Therefore, complete surgical resection and postoperative long-term follow-up of these patients is recommended.…”

Section: Discussionmentioning

confidence: 99%

“…Although inverted papilloma is a rare benign tumor, it can invade the lacrimal system, the orbit, or the intracranial cavity and destroy bone and soft tissue. 3 The preoperative differential diagnosis between inverted papilloma and SCC may be helpful in planning the method of surgery. 1 The incidence of SCC associated with inverted papillomas ranges from 2%-27% in the literature.…”

Section: Introductionmentioning

confidence: 99%

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Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

et al. 2018

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Background Differentiating inverted papilloma from squamous cell carcinoma (SCC) is sometimes difficult. We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with inverted papilloma or SCC. Methods Serum and tissue samples for the analysis of SCCA1, SCCA2, and SCC antigen were taken from 18 patients with sinonasal inverted papilloma and 23 cases with sinonasal SCC. The SCCA1, SCCA2, and SCC antigen levels were determined. Results The serum SCCA1 concentration was significantly higher in the inverted papilloma group than in the SCC group, whereas the serum SCCA2 level was significantly higher in the SCC group than in the inverted papilloma group. Conclusion Patients with sinonasal inverted papilloma predominantly express SCCA1 protein, whereas those with SCC predominantly express SCCA2. This suggests that combined measurements of both serum SCCA1 and SCCA2 concentrations can be very useful for distinguishing sinonasal inverted papilloma from SCC.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

et al. 2018

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“…Early symptoms of paranasal sinus tumor may be missed, hence causing delay in diagnosis. These patients may just present with non-specific sinonasal symptoms like nasal obstruction, nasal discharge, epistaxis and facial pain, which are similar to those typical inflammatory condition [4,5]. The ocular presentation signifies a more extensive stage of disease though it is not a common symptoms, and at most of time occurs following malignant transformation of the lesion [6].…”

Section: Discussionmentioning

confidence: 99%

“…Despite being benign in nature, it tends to recur, and be locally aggressive and has the propensity to be associated with malignancy [7,8]. The association of inverted papilloma with squamous cell carcinoma is well recognized [2,5,6,9]. The most frequent location of this type of tumor was lateral nasal wall, followed by maxillary sinus, ethmoidal labyrinth, nasal septum, frontal sinus and the sphenoid sinus [7].…”

Section: Discussionmentioning

confidence: 99%

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Acute proptosis: Unusual initial presentation of sinonasal inverted papilloma

Ibrahim¹,

Abdullah

Kandasamy

et al. 2017

JAD

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Survival Outcomes of De Novo vs Inverted Papilloma–Associated Sinonasal Squamous Cell Carcinoma

Lee

Peterson

Embry

et al. 2021

JAMA Otolaryngol Head Neck Surg

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IMPORTANCE Overall, the prognosis of sinonasal squamous cell carcinoma (SCC) is poor. This malignancy can arise de novo or from inverted papillomas, but it is unclear whether survival differences between the 2 pathologies exist.OBJECTIVE To assess for survival differences between patients with sinonasal de novo SCC (dnSCC) and those with inverted papilloma-associated SCC (IPSCC).DATA SOURCES A search of Ovid MEDLINE, Embase, Scopus, and the Cochrane Library from inception to January 23, 2020, with cross-referencing of retrieved studies, was performed. Additional data were requested from authors.STUDY SELECTION Inclusion and exclusion criteria were designed to capture studies with survival outcomes of adults with sinonasal SCC who underwent regular treatment. Clinical trials, cohort studies, case-control studies, and case series with more than 10 adults aged 18 years or older with sinonasal SCC were included. Exclusion criteria were studies on non-SCC sinonasal neoplasms, studies without histopathologic diagnoses, non-English language articles, nonhuman animal studies, and abstract-only articles. Two blinded investigators (J.J.L., A.M.P., T.W.E., or N.S.W.) screened each abstract and full text, and a third investigator (J.J.L. or P.P.) adjudicated discrepancies. Of 729 unique citations, 26 studies of 1194 total patients were included.DATA EXTRACTION AND SYNTHESIS Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines were followed. The Methodological Index for Nonrandomized Studies (MINORS) criteria were used to assess study quality. Two blinded investigators (J.J.L., A.M.P., T.W.E., or N.S.W.) independently extracted data from each study. Data were pooled using a random-effects model. MAIN OUTCOMES AND MEASURESThe primary outcome was overall survival, and secondary outcomes were disease-free and disease-specific survival. Before data collection, it was hypothesized that the dnSCC cohort would have worse survival outcomes than the IPSCC cohort. RESULTSOne study of patients with dnSCC, 12 studies of patients with IPSCC, and 5 studies with both cohorts were included in the meta-analysis of overall survival. The pooled 5-year overall survival rate for 255 patients with dnSCC was 56% (95% CI, 41%-71%; I 2 = 83.8%) and for 475 patients with IPSCC was 65% (95% CI, 56%-73%; I 2 = 75.7%). Five comparative studies of both cohorts totaling 240 patients with dnSCC and 155 patients with IPSCC were included in another meta-analysis. The pooled overall survival hazard ratio was 1.87 (95% CI, 1.24-2.84; I 2 = 0%).CONCLUSIONS AND RELEVANCE This systematic review and meta-analysis found that patients with dnSCC had almost a 2-fold increased risk of mortality compared with those with IPSCC. Large, multicenter studies are necessary to validate these findings before considering treatment alterations such as de-escalation based on histopathology.

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Clinical management of squamous cell carcinoma associated with sinonasal inverted papilloma

Cited by 28 publications

References 22 publications

Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

Acute proptosis: Unusual initial presentation of sinonasal inverted papilloma

Survival Outcomes of De Novo vs Inverted Papilloma–Associated Sinonasal Squamous Cell Carcinoma

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