Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

Yasumatsu, Ryuji; Nakano, Tomoko; Sato, Masanobu; Jiroumaru, Rina; Hashimoto, Kazuki; Kogo, Ryunosuke; Wakasaki, Takahiro; Nakashima, Torahiko; Nakagawa, Takashi

doi:10.1002/hed.25351

Cited by 8 publications

(7 citation statements)

References 19 publications

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“…While SCCA is produced by two homologous genes, SCCA-1 and SCCA-2, SCCA-1 plays a pivotal role in the diagnosis of IP, with SCCA-2 providing limited diagnostic utility. Previous analysis of SCCA-2 in CRS, IP, and sinonasal SCC demonstrated that SCCA-2 levels are significantly higher in sinonasal SCC than in CRS and IP when measured using different in-house assay systems [27]. Our results for SCCA-2 levels in IP and CRS were consistent with that report [27].…”

Section: Discussionsupporting

confidence: 90%

Prospective Analysis of Squamous Cell Carcinoma Antigen-1 and -2 for Diagnosing Sinonasal Inverted Papilloma

Hirakawa,

Ikegami,

Toyama

et al. 2024

JCM

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Background: The goal of this research was to confirm whether preoperative serum squamous cell carcinoma antigen (SCCA)-1 and -2 levels are useful diagnostic markers for sinonasal inverted papilloma (IP) in a prospective study. Methods: Participants were 102 patients who underwent consecutive endoscopic sinus surgery: 18 with IP, two with other types of papilloma, 77 with chronic rhinosinusitis, four with sinonasal cancer, and one with hemangioma. SCCA-1 and SCCA-2 were measured preoperatively by an automatic chemiluminescence immunoassay and an enzyme-linked immunosorbent assay, respectively. Results: SCCA-1 and SCCA-2 values were significantly correlated (r = 0.603, p < 0.001). Receiver operating characteristic analysis for differentiating papilloma (IP and other types of papilloma) from other diseases yielded an area under the curve of 0.860, with a Youden index of 1.75. Combined with SCCA-2 analysis, the detection system had a sensitivity and specificity of 0.65 and 0.98, respectively. While our study did not find a strong link between SCCA levels and skin or lung diseases, smoking status may influence SCCA levels in IP patients (p = 0.035). We recommend a cutoff value of 1.8 ng/mL for SCCA-1 in IP diagnosis. Conclusions: SCCA-1 and SCCA-2 when combined with imaging and pathology hold promise for enhancing the preoperative detection of IP, which would be a valuable contribution to clinical practice.

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Section: Discussionsupporting

confidence: 90%

Prospective Analysis of Squamous Cell Carcinoma Antigen-1 and -2 for Diagnosing Sinonasal Inverted Papilloma

Hirakawa,

Ikegami,

Toyama

et al. 2024

JCM

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“…Yasumatsu et al [29] reported that SCCA1 was more strongly expressed in SIP tissues than in SCC tissues and, conversely. On the contrary, SCCA2 was predominantly expressed in SCC tissues.…”

Section: Discussionmentioning

confidence: 97%

A rare case of cervical squamous cell carcinoma combined with sinonasal inverted Papilloma: A case report

Hou¹,

Peng

Zhang

et al. 2022

Preprint

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Background: Cervical cancer is the fourth most common malignancy in women worldwide, and sinonasal inverted papilloma (SIP) is a rare benign sinus tumor and has the characteristics of destructive growth pattern, high recurrence rate and easy canceration. Cervical squamous cell carcinoma (SCC) combined with SIP has not been reported so far. Case Presentation: A 55-year-old woman was diagnosed with cervical SCC in our center and treated with concurrent radiochemotherapy. During the follow-up period, SIP was found twice and both underwent endoscopic left nasal tumor resection. The clues that the diseases were found were the abnormal rise of squamous cell carcinoma antigen (SCCA). SCCA level decreased to normal after operations.Discussion and Conclusion: (1) when the cervical lesions have resolved satisfactorily but the SCCA is still high, other sites should be promptly investigated for the cause, which may lead to earlier detection and earlier treatment of SIP. (2) Combined with the literature, we recommend that SCCA can be used as a routine monitoring index for SIP. If available, a combination of SCCA1 and SCCA2 can be tried for further judgement. (3) For SIP with a high recurrence rate, can anti-HPV treatment be taken after operation to reduce the risk of recurrence?

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Section: Discussionmentioning

confidence: 99%

“…Yasumatsu et al reported that SCCA1 was more strongly expressed in SIP tissues than in SCC tissues. 30 In contrast, SCCA2 was predominantly expressed in SCC tissues. The results of the Yasumatsu study are consistent with these previous studies of cervical cancer that found SCCA2 levels were more strongly expressed in malignant cervical tissues than in normal tissues.…”

mentioning

confidence: 95%

“…The results of the Yasumatsu study are consistent with these previous studies of cervical cancer that found SCCA2 levels were more strongly expressed in malignant cervical tissues than in normal tissues. 30,31 Appropriate tumor markers can help clinicians identify various neoplastic diseases, including SIP and cervical cancer. We could have determined whether SIP or cervical SCC played a major role in the increase in serum SCCA concentrations by detecting SCCA1 and SCCA2 levels.…”

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confidence: 99%

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A Rare Case of Cervical Squamous Cell Carcinoma Concurrent with Sinonasal Inverted Papilloma: A Case Report

Hou¹,

Peng²,

Zhang³

et al. 2022

IJWH

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Introduction Cervical cancer is the fourth most common malignancy in women worldwide, and sinonasal inverted papilloma (SIP) is a rare benign sinus tumor with characteristics including a destructive growth pattern, high recurrence rate, and common malignant transformation. Cervical squamous cell carcinoma (SCC) combined with SIP has not been reported thus far. Case Presentation A 55-year-old woman was diagnosed with cervical SCC in our center and treated with concurrent radiochemotherapy. During the follow-up period after the completion of cervical cancer treatment, the progression of cervical squamous cell carcinoma was first considered because the squamous cell carcinoma antigen (SCCA) levels remained high and slowly increased. However, SIP was found after a detailed investigation. The SCCA levels returned to normal after surgery. Two months after the surgery, because SCCA slowly increased again, it was found that the SIP recurred. After additional surgical treatment, the SCCA level returned to normal. Discussion and Conclusion First, SCCA is an important indicator for monitoring changes in cervical SCC. When the changes in SCCA levels are inconsistent with the prognosis of cervical SCC, we should be vigilant about considering the possibility of other diseases existing at other sites in the body, which might lead to the earlier detection and treatment of SIP. Second, We recommended that SCCA be used as a routine monitoring index for SIP. If available, SCCA1 and SCCA2 should be evaluated to provide a more detailed assessment. Finally, for a high recurrence rate of SIP, anti-HPV treatment might be considered to reduce the risk of recurrence.

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Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

Cited by 8 publications

References 19 publications

Prospective Analysis of Squamous Cell Carcinoma Antigen-1 and -2 for Diagnosing Sinonasal Inverted Papilloma

Prospective Analysis of Squamous Cell Carcinoma Antigen-1 and -2 for Diagnosing Sinonasal Inverted Papilloma

A rare case of cervical squamous cell carcinoma combined with sinonasal inverted Papilloma: A case report

A Rare Case of Cervical Squamous Cell Carcinoma Concurrent with Sinonasal Inverted Papilloma: A Case Report

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