Clinical leishmaniasis in dogs living in the <scp>UK</scp>

Silvestrini, P.; Batchelor, Daniel J.; Allenspach, Karin; Maunder, Christina; Seth, Mayank; Mas, Alicia; Hill, Tracy; Serrano, Gabriel; Roura, Xavier; Planellas, Marta; German, Alexander J.; Pastor, Josep

doi:10.1111/jsap.12503

Cited by 17 publications

(11 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, a likely autochthonous case has been reported in the U.K. [48]. Although sand fly species that transmit Leishmania are not present in these regions [47,49,50], dog-to-dog transmission has been established [47,48]. This strongly suggests that Leishmania infection can maintain itself within groups of infected dogs.…”

Section: Discussionmentioning

confidence: 99%

Leishmania Infection during Chemotherapy in a Dog Diagnosed with Multicentric Large B-Cell Lymphoma—A Diagnostic Challenge

et al. 2021

View full text Add to dashboard Cite

Dogs with lymphoma are at risk of developing clinical complications due to immunosuppression and side effects of chemotherapy. Clinical reports of concurrent lymphoma and leishmaniasis are rare and confined to single cases of comorbidity at presentation. Herein, we describe a case of lymphoma during maintenance chemotherapy in which bone marrow cytology showed myelodysplasia associated with leishmaniasis. The dog was a seven-year-old intact female Parson Russel Terrier with a two-week history of generalized lymphadenopathy. Diagnosis of multicentric high-grade B-cell lymphoma stage Va was carried out with cytological and cytofluorimetric assays of external lymph nodes, abdominal ultrasound, chest radiology, and lymphoid blasts blood smear examination. The dog lived and had traveled in endemic areas of Leishmania with uninterrupted prevention against sand fly bites by an insecticide-impregnated collar and presented seronegativity to Leishmania at presentation. Chemotherapy for lymphoma was successful and the patient achieved complete remission. Approximately eight months after the diagnosis, a persistent pancytopenia was assessed. Unexpectedly, Leishmania amastigotes were identified in the bone marrow. Combined treatment rounds were administered with antileishmanial and antineoplastic drugs for approximately eight months. Eventually, lymphoma relapsed and became unresponsive to chemotherapy, and the dog was euthanatized. Canine lymphoma overlapping with subsequent Leishmania infection as a complication is rare and lacks specific clinical manifestations. A delayed diagnosis of leishmaniasis may occur. We suggest considering leishmaniasis as part of the differential diagnosis of persistent pancytopenia in dogs with lymphoma, particularly in dogs who reside or travel to endemic areas, when treatment fails or abnormal laboratory findings are present.

show abstract

Section: Discussionmentioning

confidence: 99%

Leishmania Infection during Chemotherapy in a Dog Diagnosed with Multicentric Large B-Cell Lymphoma—A Diagnostic Challenge

et al. 2021

View full text Add to dashboard Cite

show abstract

“…A total of 28 articles were selected, according to selection criteria, representing a total of 1403 cases of non-autochthonous leishmaniosis or subclinical infection in dogs (Best et al, 2014;Cleare et al, 2014;Dandrieux et al, 2018;Farkas et al, 2011;Gin et al, 2021;Hamel et al, 2012Hamel et al, , 2011Helm et al, 2013;Iqbal et al, 2002;Kawamura et al, 2010;Kotnik et al, 2021;Latif et al, 2019;Leschnik et al, 2008;Menn et R. Rocha et al Naucke et al, 2016;Pavel et al, 2017;Rotureau et al, 2006;Schäfer et al, 2019aSchäfer et al, , 2019bShaw et al, 2008;Schönian et al, 2003;Silvestrini et al, 2016;Tanase et al, 2018;Teske et al, 2002;Vilhena et al, 2014;Wagner et al, 2020;Willi et al, 2015). For 689 individuals, the likely place of infection was described, comprising 22 different countries or territories, represented in Fig.…”

Section: Canine Leishmania Infection and Leishmaniosismentioning

confidence: 99%

A global perspective on non-autochthonous canine and feline Leishmania infection and leishmaniosis in the 21st century

Rocha¹,

Pereira

Maia³

2023

Acta Tropica

View full text Add to dashboard Cite

“…Human and canine leishmaniosis is endemic in the Mediterranean Basin, the Middle East, and sub-tropical and tropical regions of the world, but over the past few years, with climatic zone shifts induced by climate change, population instability, and globalization, the disease has been experiencing a clear geographical expansion [9,[102][103][104][105][106][107][108][109]. Several cases have been reported in non-endemic areas [31,110,111] such as the UK [112,113], the United States [114,115], New Caledonia [116], Germany, and Poland [110]. Besides, the incidence of CanL is increasing in endemic countries such as Spain and France [117].…”

Section: Prevention Control and Public Health Considerationsmentioning

confidence: 99%

Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis

Segarra

2021

Microorganisms

View full text Add to dashboard Cite

Leishmaniasis is an emerging, uncontrolled, and neglected zoonotic disease. Climate change is contributing to its ongoing global expansion. The dog is the main reservoir; hence the importance of implementing effective treatment, prevention, and control measures in this animal species to protect public health. However, although the standard treatment for canine leishmaniosis (CanL) is effective, it does not provide full parasitological clearance, and side effects and drug resistance have been described. The host’s immune system plays a key role in the establishment and evolution of leishmaniasis. Dietary nucleotides modulate the immune response and, given their reported efficacy and safety in sick and clinically healthy Leishmania-infected dogs and because they represent a sustainable option with no associated side effects or resistance, they could be included within the prevention, treatment, and control strategies for leishmaniasis. This article briefly summarizes the scientific literature on CanL management, including unresolved issues, and reviews the scientific evidence on immunomodulatory effects of dietary nucleotides in different animal species. It also proposes a CanL management algorithm, including nucleotides. It is concluded that nutritional modulation of the immune response with nucleotides can contribute to better management of leishmaniasis following a One Health approach, especially in the COVID-19 era.

show abstract

Clinical leishmaniasis in dogs living in the UK

Cited by 17 publications

References 39 publications

Leishmania Infection during Chemotherapy in a Dog Diagnosed with Multicentric Large B-Cell Lymphoma—A Diagnostic Challenge

Leishmania Infection during Chemotherapy in a Dog Diagnosed with Multicentric Large B-Cell Lymphoma—A Diagnostic Challenge

A global perspective on non-autochthonous canine and feline Leishmania infection and leishmaniosis in the 21st century

Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis

Contact Info

Product

Resources

About