Clinical islet transplantation in Japan

Kenmochi, Takashi; Asano, Tomohiko; Maruyama, M.; Saigo, Kenichi; Akutsu, Naotake; Iwashita, C.; Ohtsuki, Kazunori; Ito, Taihei

doi:10.1007/s00534-008-0020-3

Cited by 18 publications

(15 citation statements)

References 33 publications

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“…Recently the efficacy of islet transplantation with NHBD was shown to be inferior to islet transplantation with BDD 18 . However, the recipients had to wait more than 2 years before receiving the second islet infusion at their institute.…”

Section: Current Status Of Islet Transplantationmentioning

confidence: 99%

“…17 Recently the efficacy of islet transplantation with NHBD was shown to be inferior to islet transplantation with BDD. 18 However, the recipients had to wait more than 2 years before receiving the second islet infusion at their institute. Therefore their cases were quite different from the Edmonton protocol and more similar to single donor islet transplantation.…”

Section: Islet Transplantation Using Non-heart Beating Donorsmentioning

confidence: 99%

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Islet cell transplantation for Type 1 diabetes

Matsumoto

2010

Journal of Diabetes

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Islet transplantation is an attractive concept for the treatment of Type 1 diabetes because of its potential high efficacy and minimal invasion to patients. The treatment may effectively control blood glucose for brittle Type 1 diabetes, resulting in a marked reduction in hypoglycemic episodes and improvements in HbA1c. In addition, approximately 70% of transplanted Type 1 diabetic patients have achieved insulin independence. However, there are still important issues to be addressed before this treatment is widely applicable, including difficulty in maintaining insulin independence, low islet isolation success rate, multiple donor requirements, and side effects associated with the use of immunosuppressants. Donor shortage is another dilemma. To address the issue of donor shortage, living donor islet transplantation and bioartificial islet transplantation using pig islets are being evaluated. Bioartificial islet transplantation could be the ultimate solution of the donor shortage. Currently, overcoming immunological hurdles, establishing reliable islet isolation methods, and controlling porcine endogenous retrovirus are the primary obstacles to the implementation of this treatment. If bioartificial islet transplant becomes a clinical reality, it may even be applicable in the treatment of select Type 2 diabetic patients. β‐Cell regeneration from naïve pancreas and β‐cell generation from embryonic stem cells or induced pluripotent stem cells are the next‐generation treatments for Type 1 diabetes.

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Section: Current Status Of Islet Transplantationmentioning

confidence: 99%

Section: Islet Transplantation Using Non-heart Beating Donorsmentioning

confidence: 99%

Islet cell transplantation for Type 1 diabetes

Matsumoto

2010

Journal of Diabetes

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“…In Japan, isolation of pancreatic islets started in 2003 and islet transplantation began in 2004. Sixty-five islet isolations and 34 islet transplantations to 18 type 1 diabetic patients have been performed [4]. The demand has increased every year.…”

Section: Introductionmentioning

confidence: 99%

“…Methods Islets prepared from Lewis rats by collagenase digestion and Histopaque gradient centrifugation, followed by culture in medium containing 0.1% sericin for 3 days, were cryopreserved using 0.1, 0.5, 1, 2, and 5% sericin or FBS. DMSO (1,4,7,10,and 15%) was added to the medium as a cryoprotectant. After thawing, on days 1, 4, 7, and 14, viable islets were counted in order to evaluate their survival.…”

mentioning

confidence: 99%

Effect of the silk protein sericin on cryopreserved rat islets

Ohnishi

Murakami

Morikawa

et al. 2011

J Hepato Biliary Pancreat

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“…The donation procedure from a nonheart-beating donor is more complicated than that from a brain dead donor [11]. Pancreatic islet transplantation has been conducted 34 times in 18 patients in Japan [12] while 649 times in 325 patients between 1999 to 2007 in western countries according to the Collaborative Islet Transplant Registry [13]. …”

Section: Introductionmentioning

confidence: 99%

Knowledge and Demand for Information about Islet Transplantation in Patients with Type 1 Diabetes

Yamamoto

Nishigaki

Kato

et al. 2011

Journal of Transplantation

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This cross-sectional study based on self-administrated questionnaire was conducted to investigate knowledge, related factors, and sources of information regarding islet transplantation in patients with type 1 diabetes in Japan. Among 137 patients who provided valid responses, 67 (48.9%) knew about islet transplantation. Their main source of information was newspapers or magazines (56.7%) and television or radio (46.3%). However, 85.8% of patients preferred the attending physician as their source of information. Although more than half of the patients were correctly aware of issues related to islet transplantation, the following specific issues for islet transplantation were not understood or considered, and there was little knowledge of them: need for immunosuppressants, lifestyle and dietary adaptations, fewer bodily burdens, and complications. The experience of hypoglycaemia, a high level of academic background, frequent self-monitoring of blood glucose, and the use of continuous subcutaneous insulin infusion were related to higher knowledge about islet transplantation.

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Clinical islet transplantation in Japan

Cited by 18 publications

References 33 publications

Islet cell transplantation for Type 1 diabetes

Islet cell transplantation for Type 1 diabetes

Effect of the silk protein sericin on cryopreserved rat islets

Knowledge and Demand for Information about Islet Transplantation in Patients with Type 1 Diabetes

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