Clinical Improvement in Antiphospholipid Syndrome After Rituximab Therapy

Adamson, Rosemary; Sangle, Shirish; Kaul, Arvind; Hughes, G. R. V.; D’Cruz, David

doi:10.1097/rhu.0b013e31818f38d4

Cited by 24 publications

(16 citation statements)

References 13 publications

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“…Nevertheless, early results are encouraging. Our first patient treated with Rituximab showed not only a significant fall in aPL levels, but, interestingly a marked improvement in the stability of Warfarin control Adamson et al 2008).…”

Section: Immunosuppressive Therapymentioning

confidence: 63%

Hughes syndrome (the antiphospholipid syndrome): a disease of our time

Hughes

2010

Inflammopharmacol

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A pro-thrombotic condition was described in 1983 which was characterised by the presence of circulating antiphospholipid antibodies, as well as peripheral thrombosis (e.g. DVT), a tendency to internal organ involvement, repeated miscarriage, and, occasionally, thrombocytopenia (aPL) (Hughes, Br Med J 287:1088-1089, 1983). Previously, there had been a number of observations, mainly in patients with lupus having "false positive" tests for syphilis, miscarriage and circulating lupus anticoagulants. The description in 1983 had three notable features (a) a detailed comprehensive clinical picture of the syndrome; (b) this description differed from other coagulopathies in showing a propensity for arterial thrombosis (e.g. stroke and heart attack); and (c) this was a syndrome quite independent from lupus. There are indications that the primary antiphospholipid syndrome will turn out to be more common than lupus, though this could still be a reflection of referral practice.

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Section: Immunosuppressive Therapymentioning

confidence: 63%

Hughes syndrome (the antiphospholipid syndrome): a disease of our time

Hughes

2010

Inflammopharmacol

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“…2,3 We report a patient with more than 15 venous and arterial thrombotic events uncontrolled by anticoagulant and anti-plt agents, with progression to CAPS. Immunomodulants including rituximab, steroids, i.v.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

“…There are a few anecdotal reports about the effectiveness of rituximab in APS. 2 Other immunomodulant measures including plasmapheresis alone or in combination with i.v. Ig have been proposed as the treatment of choice in patients with CAPS.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

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Successful treatment of a case of catastrophic antiphospholipid syndrome with autologous BMT: case report and review of literature

Owaidah

Maghrabi

Elkarouri

et al. 2010

Bone Marrow Transplant

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“…Current knowledge clearly suggests the need for further clinical trials to evaluate the effect of rituximab in the treatment of resistant APS [Erre et al 2008]. In December 2008 the first report was published of a patient with APS without thrombocytopenia showing functional improvement after rituximab therapy and supports the growing body of evidence favoring the use of rituximab [Adamson et al 2008].…”

Section: Treatments Under Investigationmentioning

confidence: 96%

Management of antiphospholipid syndrome

Papa

Vaso

2010

Therapeutic Advances in Musculoskeletal

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The antiphospholipid syndrome (APS) is an autoimmune disorder presenting with tissue injury in various organs related to large-or small-vessel thrombosis associated with antiphospholipid and antiprotein/phospholipid complex antibodies. Although the pathophysiology, diagnosis, and clinical scenario may seem clear and straightforward, a more detailed examination reveals a more complex and uncertain picture related to the management of APS. This article reviews the current situation relating to APS therapy by evaluating the different clinical features of the syndrome ranging from thrombosis to pregnancy complications together with new strategies and pharmacological approaches.

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Clinical Improvement in Antiphospholipid Syndrome After Rituximab Therapy

Cited by 24 publications

References 13 publications

Hughes syndrome (the antiphospholipid syndrome): a disease of our time

Hughes syndrome (the antiphospholipid syndrome): a disease of our time

Successful treatment of a case of catastrophic antiphospholipid syndrome with autologous BMT: case report and review of literature

Management of antiphospholipid syndrome

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