Clinical importance ofBilophila wadsworthia

Finegold, Sydney M.; Summanen, Paula; Gerardo, S. Hunt; Baron, Ellen Jo

doi:10.1007/bf01967799

Cited by 60 publications

(35 citation statements)

References 7 publications

(1 reference statement)

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“…wadsworthia was first identified in 1988 during a study characterizing the microbiome of gangrenous appendicitis. The organism is a common anaerobic isolate in infections, 53 including ear, biliary tract and liver abscess, 54 and is the third most common isolate detected in appendicitis, with abundance correlating with severity of disease. As a b-lactamase producer, B. wadsworthia is resistant to most antibiotics, with metronidazole being the only effective agent against all tested strains.…”

Section: Diet and Gut Microbial Respiration Of Taurinementioning

confidence: 99%

Taurocholic acid metabolism by gut microbes and colon cancer

Ridlon¹,

Wolf²,

Gaskins³

2016

Gut Microbes

237

229

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Colorectal cancer (CRC) is one of the most frequent causes of cancer death worldwide and is associated with adoption of a diet high in animal protein and saturated fat. Saturated fat induces increased bile secretion into the intestine. Increased bile secretion selects for populations of gut microbes capable of altering the bile acid pool, generating tumor-promoting secondary bile acids such as deoxycholic acid and lithocholic acid. Epidemiological evidence suggests CRC is associated with increased levels of DCA in serum, bile, and stool. Mechanisms by which secondary bile acids promote CRC are explored. Furthermore, in humans bile acid conjugation can vary by diet. Vegetarian diets favor glycine conjugation while diets high in animal protein favor taurine conjugation. Metabolism of taurine conjugated bile acids by gut microbes generates hydrogen sulfide, a genotoxic compound. Thus, taurocholic acid has the potential to stimulate intestinal bacteria capable of converting taurine and cholic acid to hydrogen sulfide and deoxycholic acid, a genotoxin and tumor-promoter, respectively.

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Section: Diet and Gut Microbial Respiration Of Taurinementioning

confidence: 99%

Taurocholic acid metabolism by gut microbes and colon cancer

Ridlon¹,

Wolf²,

Gaskins³

2016

Gut Microbes

237

229

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“…[78][79][80] Sampling problems may have influenced the results of these studies. Needle aspiration of early lesions has yielded recognized pathogens in a minority of the examined lesions (9/41; S. aureus in 8/41 lesions and S. milleri in 1/41).…”

Section: Infectionmentioning

confidence: 99%

“…milleri, Bilophila wadsworthia, and anaerobes. 35,[77][78][79][80][81][82] The species have been isolated from a wide range of lesions at many different stages and definitions of hidradenitis. Frequently, the different species of bacteria have also been found in only a few cases as a G.B.E.…”

Section: Infectionmentioning

confidence: 99%

Hidradenitis Suppurativa

Jemec

2002

JCMS

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“…The lower intestinal tract is the natural habitat of B. wadsworthia [141], and it is a suspected pathogen which is recovered from several di¡erent clinical specimens, especially from appendicitis [142,143]. Clinical isolates of B. wadsworthia utilize taurine and taurine-conjugated cholic acid derivatives [144] and it is now clear that the clinical isolates and strain RZATAU have indistinguishable growth with taurine as an electron acceptor and formate as electron donor [145].…”

Section: Sulfonates As Electron Acceptors In Anaerobic Respirationmentioning

confidence: 99%

Microbial desulfonation

Cook

1998

FEMS Microbiology Reviews

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Organosulfonates are widespread compounds, be they natural products of low or high molecular weight, or xenobiotics. Many commonly found compounds are subject to desulfonation, even if it is not certain whether all the corresponding enzymes are widely expressed in nature. Sulfonates require transport systems to cross the cell membrane, but few physiological data and no biochemical data on this topic are available, though the sequences of some of the appropriate genes are known. Desulfonative enzymes in aerobic bacteria are generally regulated by induction, if the sulfonate is serving as a carbon and energy source, or by a global network for sulfur scavenging (sulfate starvation induced (SSI) stimulon) if the sulfonate is serving as a source of sulfur. It is unclear whether an SSI regulation is found in anaerobes. The anaerobic bacteria examined can express the degradative enzymes constitutively, if the sulfonate is being utilized as a carbon source, but enzyme induction has also been observed. At least three general mechanisms of desulfonation are recognisable or postulated in the aerobic catabolism of sulfonates: (1) activate the carbon neighboring the C y Q bond and release of sulfite assisted by a thiamine pyrophosphate cofactor; (2) destabilize the C y Q bond by addition of an oxygen atom to the same carbon, usually directly by oxygenation, and loss of the good leaving group, sulfite; (3) an unidentified, formally reductive reaction. Under SSIS control, different variants of mechanism (2) can be seen. Catabolism of sulfonates by anaerobes was discovered recently, and the degradation of taurine involves mechanism (1). When anaerobes assimilate sulfonate sulfur, there is one common, unknown mechanism to desulfonate the inert aromatic compounds and another to desulfonate inert aliphatic compounds; taurine seems to be desulfonated by mechanism (1).

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Clinical importance ofBilophila wadsworthia

Cited by 60 publications

References 7 publications

Taurocholic acid metabolism by gut microbes and colon cancer

Taurocholic acid metabolism by gut microbes and colon cancer

Hidradenitis Suppurativa

Microbial desulfonation

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